Results 71 to 80 of about 1,689,456 (287)

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

FEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise, Tiziano Mazza, Raffaella Scanga, Lara Console, Michele Galluccio, Cesare Indiveri   +5 more
wiley   +1 more source

Change in self-reported somatic symptoms among patients in opioid maintenance treatment from baseline to 1-year follow-up

BMC Psychiatry
Background High somatic comorbidity is common among patients in treatment for opioid use disorder (OUD). The present study aims to investigate changes in self-reported somatic health conditions and somatic symptoms among patients entering opioid ...
Endre Dahlen Bjørnestad, John-Kåre Vederhus, Thomas Clausen   +2 more
doaj   +1 more source

Cancer‐associated mutations in endometriosis reframe a benign disease through molecular oncology

Molecular Oncology, EarlyView.
This review aims to comprehensively analyse cancer‐associated somatic mutations (CAMs) present in endometriotic lesions, emphasizing their biological roles, spatial distribution and implications for translational applications in medicine. By contextualizing a benign state within a genomic framework, this analysis seeks to establish its value as a ...
Clarissa Mujacic, Maria Concetta Vitale, Rita Siino, Emilia Di Giovanni, Carla Ferrante Bannera, Enrico Di Marco, Andrea Gottardo, Tancredi Didier Bazan Russo, Nadia Barraco, Alessandro Perez, Valerio Gristina, Antonio Galvano, Giuseppe Badalamenti, Antonio Russo, Viviana Bazan, Lorena Incorvaia   +15 more
wiley   +1 more source

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

Management of somatic symptom disorder [PDF]

Dialogues in Clinical Neuroscience, 2018
This review paper gives an overview of the management of somatic symptom disorder. It starts with a description of the clinical problem of patients with persistent bodily distress, discusses classificatory, epidemiological, and etiological issues and then describes the evidence and practical principles of dealing with these patients who are often seen ...
openaire   +2 more sources

Evaluating the effect of γ‐oryzanol on MASLD pathology using a medaka fish model

FEBS Open Bio, EarlyView.
This study explores a liver disease called MASLD, which is increasing worldwide and can lead to serious damage. Researchers used medaka fish instead of rodents to test a food compound, γ‐oryzanol. Fish fed this compound had less liver fat and healthier gut bacteria.
Yukako Ito, Haduki Asano, Ayano Ueki, Joe Sakamoto, Yasuhiro Kamei, Hayato Tokumoto, Ayaka Yazawa, Shigeki Kamitani   +7 more
wiley   +1 more source

Identification of (20R)‐protopanaxadiol from Panax ginseng as a novel anti‐SARS‐CoV‐2 compound

FEBS Open Bio, EarlyView.
We established a noninfectious BAC‐based SARS‐CoV‐2 replicon that enables antiviral screening under BSL‐2 conditions. Using this platform, we screened 373 food‐derived compounds and identified (20R)‐protopanaxadiol from Panax ginseng as a novel inhibitor of SARS‐CoV‐2 RNA replication, highlighting the value of safe replicon systems for antiviral ...
Midori Takeda, Natsue Maezono, Rina Uchikoshi, Nobuyuki Kato, Masanori Ikeda   +4 more
wiley   +1 more source

Protocol for quantifying miRNA trafficking across the endosomal membrane

FEBS Open Bio, EarlyView.
An in vitro protocol measures miRNA uptake into endosomes isolated from mammalian cell extracts, which are free of subcellular contaminants. Performed at 37 °C in the presence of ATP, it ensures the import of single‐stranded miRNA into the endosomal lumen.
Syamantak Ghosh, Kamalika Mukherjee, Suvendra N. Bhattacharyya   +2 more
wiley   +1 more source

Mental and somatic symptoms related to suicidal ideation in patients visiting a psychosomatic clinic in Japan

, 2009
Kouichi Yoshimasu1, Tetsuya Kondo2,4, Shoji Tokunaga3, Yoshio Kanemitsu2, Hideyo Sugahara2, Mariko Akamine2, Kanichiro Fujisawa2, Kazuhisa Miyashita1, Chiharu Kubo21Department of Hygiene, School of Medicine, Wakayama Medical University, Wakayama, Japan ...
Kouichi Yoshimasu, Shoji Tokunaga, Tetsuya Kondo, et al   +3 more
core  

Lifetime abuse and somatic symptoms among older women and men in Europe [PDF]

, 2019
BACKGROUND: Research suggests that survivors of interpersonal violence have an increasing experience of bodily symptoms. This study aims to scrutinise the association between lifetime abuse and somatic symptoms among older women and men, considering ...
Lindert, J, Torres-Gonzalez, F, Giovanni Lamura (206155), Henrique Barros (162786), Torres González, Francisco, Elisabeth Ioannidi-Kapolou, Soares, JJF, Mindaugas Stankunas, Lindert, Jutta,, Lindert, Jutta, Stankunas, M, Lamura, G, Giovanni Lamura, Bahareh Eslami (5769464), Jutta Lindert, Francisco Torres-Gonzalez (210185), Eslami, Bahareh,, Barros, H, Melchiorre, Maria Gabriella, Barros, Henrique, Jutta Lindert (286091), Di Rosa, Mirko,, Barros, Henrique,, Eslami, B, Di Rosa, Mirko, Torres-Gonzalez, Francisco, Soares, Joaquim J. F.,, Henrique Barros, Bahareh Eslami, Eslami, Bahareh, Ioannidi-Kapolou, E, Ioannidi-Kapolou, Elisabeth,, Maria Gabriella Melchiorre (7164224), Torres-Gonzalez, Francisco,, Soares, Joaquim J. F., Melchiorre, MG, Joaquim J F Soares, Melchiorre, Maria Gabriella,, Lamura, Giovanni, Ioannidi-Kapolou, Elisabeth, Francisco Torres-Gonzalez, Mirko Di Rosa, Mirko Di Rosa (846433), Soares, Joaquim JF, Lamura, Giovanni,, Elisabeth Ioannidi-Kapolou (286092), Di Rosa, M, Joaquim J. F. Soares (7164221), Stankunas, Mindaugas,, Maria Gabriella Melchiorre, Mindaugas Stankunas (286090), Stankūnas, Mindaugas, Soares, Joaquim J F   +52 more
core   +2 more sources