Results 191 to 200 of about 159,461 (344)

Dual functions of SNAP25 in mouse taste buds

open access: yesThe Journal of Physiology, EarlyView.
Abstract figure legend Conditional knockout of Snap25 in taste cells leads to a marked reduction in the number of sour‐responsive Type III cells in both fungiform and circumvallete papillae of mice. In behavioral assays, Snap25/Trpv1 double knockout mice display increased licking to sour tastants, suggesting impaired aversive responses.
Kengo Horie   +6 more
wiley   +1 more source

Cardiovascular outcome in 12‐month‐old male and female offspring of metformin‐treated obese mice

open access: yesThe Journal of Physiology, EarlyView.
Abstract figure legend This study described the effects of exposure to maternal obesogenic diet and metformin treatment during pregnancy on offspring cardiovascular outcomes. Maternal diet‐induced obesity and glucose intolerance led to predominantly vascular and cardiac abnormalities in 12‐month‐old female and male offspring, respectively.
Josca M. Schoonejans   +10 more
wiley   +1 more source

Innate Immune Response After Cardiac Arrest (INNATUS): A Study Protocol for an Observational Single‐Center Pilot Study

open access: yesActa Anaesthesiologica Scandinavica, Volume 69, Issue 7, August 2025.
ABSTRACT Background The treatment of cardiac arrest (CA) patients is often complicated by post‐cardiac arrest syndrome (PCAS), which involves a systemic inflammatory response. Increased levels of certain inflammatory markers (e.g., interleukin‐6 and procalcitonin) are associated with higher mortality and worse neurological outcomes.
Asser M. J. Seppä   +9 more
wiley   +1 more source

Transcriptomic profiling of dorsal root ganglia in atopic and healthy dogs: A comparative RNA sequencing study with implications in cutaneous itch research

open access: yesVeterinary Dermatology, Volume 36, Issue 4, Page 401-411, August 2025.
Background – Itch is a common symptom in skin disorders. While the neural pathways of itch transmission from the skin to the brain are well‐understood in rodents, the same pathways in dogs remain unclear. The knowledge gap hinders the development of effective treatments for canine itch‐related disorders.
Chie Tamamoto‐Mochizuki   +1 more
wiley   +1 more source

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