Results 91 to 100 of about 38,268 (270)

Signaling Can Be Uncoupled from Imaging of the Somatostatin Receptor Type 2

Molecular Imaging, 2007
Endogenous and exogenous somatostatin receptors are commonly targeted for imaging using radiopharmaceutical analogues of somatostatin. Ligand binding activates receptor-mediated signaling.
Lin Han, Dan Yang, Vikas Kundra
doaj   +1 more source

Molecular theranostics: principles, challenges and controversies

Journal of Medical Radiation Sciences, Volume 72, Issue 1, Page 156-164, March 2025.
Molecular theranostics offers a powerful tool to drive precision medicine in nuclear oncology. While theranostics is not a new principle in nuclear medicine, recent advances in instrumentation and radiopharmacy have driven a reinvigoration and a broader suite of applications.
Geoffrey Currie
wiley   +1 more source

PERCC1‐associated enteropathy: Diagnostic challenges and enteral autonomy achieved with teduglutide

JPGN Reports, EarlyView.
Abstract Congenital diarrheas and enteropathies (CODE) are rare inherited disorders characterized by early‐onset intractable diarrhea. Though progress has been made in elucidating the genetic basis of CODE, much remains to be discovered. Another challenge is the lack of curative therapies—treatment is primarily supportive including enteral and ...
Angela Tran, Vivien Nguyen, Phuong Huynh
wiley   +1 more source

Somatostatin receptor expression in multiple hemangiomas

Discover Oncology
Background Although hemangiomas frequently occur in the skin, mucosa, liver, and brain, they are rarely observed in the abdominal cavity or retroperitoneum.
Benjin Liu, Shangjian Li, Yisi Xu, Xuqi Huang, Xudong Guo, Hanbo Wang, Shaobo Jiang   +6 more
doaj   +1 more source

Quad‐SPIM: A High‐Speed, Multi‐Color Light‐Sheet Microscope for 3D Imaging of Large Cleared Human Brain Tissues

Laser &Photonics Reviews, EarlyView.
A high‐speed, multi‐color light‐sheet microscope, named quad‐SPIM, enables rapid three dimensional (3D) imaging of large cleared human brain samples with simultaneous four‐channel acquisition. This custom‐built system achieves subcellular resolution across centimeter‐scale volumes, maintaining high image quality.
Laura Perego, Franco Cheli, Samuel Bradley, Danila Di Meo, Luca Giannoni, Josephine Ramazzotti, Federica Fenizi Caria, Giuseppe Sancataldo, Michele Sorelli, Giacomo Mazzamuto, Irene Costantini, Francesco Saverio Pavone   +11 more
wiley   +1 more source

Recent Advances in Bioconjugation of Aromatic Amino Acid Residues by a Reactivity‐Guided Approach

The Chemical Record, EarlyView.
This review highlights recent advances in the bioconjugation of aromatic amino acids residues, focusing on strategies that leverage their inherent chemical reactivity to enable precise and versatile modifications of biomacromolecules, illustrating relevant applications.
Bruno M. da S. Santos, Lívia C. R. M. da Frota, Thais G. Silva, Fernanda G. Finelli   +3 more
wiley   +1 more source

Paltusotine versus octreotide: different effects on radioligand uptake in neuroendocrine tumours

Endocrine Oncology
Objective: Somatostatin receptor analogues are well-established in the treatment of metastatic gastro-enteropancreatic neuroendocrine tumours (GEP-NETs), especially for symptom control in patients with the carcinoid syndrome, and to control tumour growth.
Katharina Wang, Christoph J Auernhammer, Simon Lindner, Mathias Zacherl, Rudolf A Werner, Julian Maurer, Lea Peischer, Julia Hamati, Maximilian P Hungbauer, Thomas Knösel, Astrid Reul, Elena Kuzmenko, Diana Vetter, José Oberholzer, Umberto Maccio, Felix Beuschlein, Martin Reincke, Constanze Hantel, Karel Pacak, Ashley B Grossman, Kathrin Zitzmann, Svenja Nölting   +21 more
doaj   +1 more source

Psilocybin as a novel treatment for chronic pain

British Journal of Pharmacology, EarlyView.
Abstract Psychedelic drugs are under active consideration for clinical use and have generated significant interest for their potential as anti‐nociceptive treatments for chronic pain, and for addressing conditions like depression, frequently co‐morbid with pain.
Tate Askey, Reena Lasrado, Maria Maiarú, Gary J. Stephens   +3 more
wiley   +1 more source

Novel approaches for drug development against chronic primary pain: A systematic review

British Journal of Pharmacology, EarlyView.
Abstract Chronic primary pain (CPP) persisting for more than 3 months, associated with significant emotional distress without any known underlying cause, is an unmet medical need. Traditional or adjuvant analgesics do not provide satisfactory pain relief for a great proportion of these patients.
Valéria Tékus, Éva Borbély, Andreas Goebel, Ralf Baron, Zsófia Hajna, Zsuzsanna Helyes   +5 more
wiley   +1 more source

SSTR2 Mediates the Inhibitory Effect of SST/CST on Lipolysis in Chicken Adipose Tissue

Animals
Somatostatin shows an anti-lipolytic effect in both chickens and ducks. However, its molecular mediator remains to be identified. Here, we report that somatostatin type 2 receptor (SSTR2) is expressed at a high level in chicken adipose tissue.
Xiao Zhang, Jiannan Zhang, Tianjiao Huang, Xinglong Wang, Jiancheng Su, Jiliang He, Ningkun Shi, Yajun Wang, Juan Li   +8 more
doaj   +1 more source