Results 111 to 120 of about 69,057 (285)

Circuit dissection of the role of somatostatin in itch and pain [PDF]

, 2018
Stimuli that elicit itch are detected by sensory neurons that innervate the skin. This information is processed by the spinal cord; however, the way in which this occurs is still poorly understood.
AJ Christensen, AJ Todd, Allen C. Dickie, AM Bell, Andrew J. Todd, AP Kardon, B Duan, BL Roth, BN Armbruster, C Peirs, C Solorzano, CE Pichon Le, CL Li, D Bröhl, D Usoskin, DM Bautista, DP Roberson, DR Simmons, E Foster, E Polgár, E Vasyutina, Erika Polgár, F Cevikbas, F Proudlock, GR Dressler, H Petitjean, H Taniguchi, Hanns Ulrich Zeilhofer, Hans Jürgen Solinski, Hendrik Wildner, I Bencivinni, IM Chiu, J Braz, J Chrubasik, Jing Huang, JL Hylden, John S. Riddell, KA Boyle, Kieran A. Boyle, KK Stantcheva, L Cui, L Han, L Li, L Madisen, L Madisen, M Gutierrez-Mecinas, M Gutierrez-Mecinas, M Gutierrez-Mecinas, Mark A. Hoon, Masahiko Watanabe, Mette C. Kriegbaum, MJ Krashes, MQ Nguyen, Noboru Iwagaki, P Taurà, Pang-Yen Tseng, PS Danielian, RJ Mullen, S Sun, Santosh K. Mishra, SE Ross, SK Mishra, SK Mishra, SK Mishra, SM Carlton, SM Carlton, SR Chaplan, T Akiyama, T Hökfelt, T Hökfelt, T Lee, T Yasaka, T Zeyda, V Chapman, VE Abraira, VS Seybold, Y Lu, YG Sun, YG Sun, Z Wiesenfeld-Hallin   +79 more
core   +1 more source

Piezo2 in Mechanosensory Biology: From Physiological Homeostasis to Disease‐Promoting Mechanisms

Cell Proliferation, EarlyView.
Piezo2 channels are essential mechanotransducers regulating touch, proprioception and visceral mechanosensation across physiological systems, emerging as therapeutic targets for pathological mechanical hypersensitivity and neurogenic disorders. ABSTRACT Piezo2, a mechanically activated ion channel, serves as the key molecular transducer for touch ...
Zhebin Cheng, Zuping Wu, Mengjie Wu, Liang Xie, Qianming Chen   +4 more
wiley   +1 more source

SSTR2 Mediates the Inhibitory Effect of SST/CST on Lipolysis in Chicken Adipose Tissue

Animals
Somatostatin shows an anti-lipolytic effect in both chickens and ducks. However, its molecular mediator remains to be identified. Here, we report that somatostatin type 2 receptor (SSTR2) is expressed at a high level in chicken adipose tissue.
Xiao Zhang, Jiannan Zhang, Tianjiao Huang, Xinglong Wang, Jiancheng Su, Jiliang He, Ningkun Shi, Yajun Wang, Juan Li   +8 more
doaj   +1 more source

Erythematous Papules and Plaques in an Infant Receiving Glucagon Therapy

JEADV Clinical Practice, EarlyView.
Sara Al Janahi, Alya Al‐Ali, Meera Al Adawi, Yusra S. Al Ali, Harish Bangalore   +4 more
wiley   +1 more source

Synaptic ultrastructural alterations in human focal cortical dysplasia: Insights from volume electron microscopy

Epilepsia, EarlyView.
Abstract Objective Focal cortical dysplasia (FCD) is a developmental malformation of the cerebral cortex and a leading cause of drug‐resistant epilepsy in children and young adults. Disruption of the excitation–inhibition (E–I) balance is a hallmark of neuronal hyperexcitability in FCD, yet the underlying synaptic ultrastructural changes remain poorly ...
Gyu Hyun Kim, Na‐Young Seo, Seung‐Ki Kim, Jae‐Kyung Won, Yang Hoon Huh, Ji Yeoun Lee, Kea Joo Lee   +6 more
wiley   +1 more source

Expression of mammalian GPCRs in C. elegans generates novel behavioural responses to human ligands

BMC Biology, 2006
Background G-protein-coupled receptors (GPCRs) play a crucial role in many biological processes and represent a major class of drug targets. However, purification of GPCRs for biochemical study is difficult and current methods of studying receptor-ligand
Jansen Gert, Rademakers Suzanne, Ng Bee, Dekkers Martijn PJ, Teng Michelle S, Fraser Andrew G, McCafferty John   +6 more
doaj   +1 more source

Effects of cell therapy on seizures in animal models of epilepsy: Systematic review and meta‐analysis

Epilepsia, EarlyView.
Abstract This study was undertaken to systematically evaluate the efficacy of cell therapy in reducing seizures in animal models of chronic epilepsy. Three databases, Ovid MEDLINE, Ovid Embase, and Web of Science, were searched using predetermined eligibility criteria.
Afaf S. Altalhi, Muhammad S. Javaid, Nigel C. Jones, Kim L. Powell, Patrick Kwan, Terence J. O'Brien, Ana Antonic‐Baker   +6 more
wiley   +1 more source

TALK-1 reduces delta-cell endoplasmic reticulum and cytoplasmic calcium levels limiting somatostatin secretion

Molecular Metabolism, 2018
Objective: Single-cell RNA sequencing studies have revealed that the type-2 diabetes associated two-pore domain K+ (K2P) channel TALK-1 is abundantly expressed in somatostatin-secreting δ-cells. However, a physiological role for TALK-1 in δ-cells remains
Nicholas C. Vierra, Matthew T. Dickerson, Kelli L. Jordan, Prasanna K. Dadi, Ketaki A. Kadare, Molly K. Altman, Sarah C. Milian, David A. Jacobson   +7 more
doaj   +1 more source

Data from Specific Targeting of Somatostatin Receptor Subtype-2 for Fluorescence-Guided Surgery

, 2023
Servando Hernandez Vargas, Susanne Kossatz, Julie Voss, Sukhen C. Ghosh, Hop S. Tran Cao, Jo Simien, Thomas Reiner, Sadhna Dhingra, William E. Fisher, Ali Azhdarinia   +9 more
openalex   +1 more source

Nanoparticle‐encapsulated neuropeptide Y provides robust seizure protection in SCN1A‐derived epilepsy

Epilepsia, EarlyView.
Abstract Objective Neuropeptides have garnered great interest as potential treatments for epilepsy due to their impact on neuronal excitability through modulation of ion channels and neurotransmitter receptor activity. Neuropeptide Y (NPY) is a 36‐amino acid neuropeptide that is expressed primarily by γ‐aminobutyric acidergic (GABAergic) interneurons ...
Samantha L. Reed, Lauren M. Aiani, Eesha Faiz, Emmanuel Adediran, Morris Benveniste, Kevin S. Murnane, Martin D'Souza, Andrew Escayg, Jennifer C. Wong   +8 more
wiley   +1 more source