Results 121 to 130 of about 69,057 (285)

C1q neutralization during epileptogenesis attenuates complement‐mediated synaptic elimination and epileptiform activity

Epilepsia, EarlyView.
Abstract Objective Accumulating evidence indicates that aberrant C1q‐C3 complement signaling in microglia and astrocytes drives synaptic dysfunction and neuronal loss. C1q‐mediated synaptic dysfunction disrupts neuronal circuitry balance and can lead to network hyperexcitability in epilepsy.
Yoonyi Jeong, Hyun‐Kyoung Lim, Hayeon Kim, Juheon Lee, Siyoon Lee, Minah Suh   +5 more
wiley   +1 more source

Development of chimeric and bifunctional antagonists for CLR/RAMP receptors.

PLoS ONE, 2019
CGRP, adrenomedullin (ADM), and adrenomedullin 2 (ADM2) family peptides are important neuropeptides and hormones for the regulation of neurotransmission, vasotone, cardiovascular morphogenesis, vascular integrity, and feto‒placental development.
Chia Lin Chang, Sheau Yu Teddy Hsu
doaj   +1 more source

Interaction of Radiopharmaceuticals with Somatostatin Receptor 2 Revealed by Molecular Dynamics Simulations. [PDF]

J Chem Inf Model, 2023
Gervasoni S, Öztürk I, Guccione C, Bosin A, Ruggerone P, Malloci G.   +5 more
europepmc   +1 more source

Amyloidosis for the Gastroenterologist: A Comprehensive Systematic Review of Diagnosis and Management of Gastrointestinal Manifestations

Journal of Gastroenterology and Hepatology, EarlyView.
ABSTRACT Background Amyloidosis is a rare, multisystem disorder characterized by extracellular deposition of misfolded protein fibrils. Gastrointestinal (GI) amyloidosis is uncommon but under‐recognized due to nonspecific symptoms, but early diagnosis is critical to improve quality of life and prognosis.
Myo Jin Tang, Theng Yi Tay, Simon Gibbs, Ola Niewiadomski   +3 more
wiley   +1 more source

Controversies in NEN: An ENETS position statement on the endoscopic management of localised gastric, duodenal and rectal neuroendocrine neoplasms

Journal of Neuroendocrinology, EarlyView.
Abstract Gastric, duodenal and rectal neuroendocrine tumours (NETs) are increasingly detected due to advances in endoscopic imaging. While international guidelines provide criteria for endoscopic management, several aspects remain controversial due to limited high‐quality evidence.
Francesco Panzuto, Dermot O'Toole, Günter Klöppel, Ulrich Peter Knigge, Günter Josef Krejs, Marina Tsoli, Marco Volante, Tu Vinh Luong   +7 more
wiley   +1 more source

Challenging Tumor Heterogeneity with HER2, p16 and Somatostatin Receptor 2 Expression in a Case of EBV-Associated Lymphoepithelial Carcinoma of the Salivary Gland. [PDF]

Head Neck Pathol, 2023
Adili A, O Connor T, Wales P, Seemann M, Höller S, Hummer B, Freiberger SN, Rauthe S, Rupp NJ.   +8 more
europepmc   +1 more source

The human somatostatin receptor type 2 as an imaging and suicide reporter gene for pluripotent stem cell-derived therapy of myocardial infarction [PDF]

, 2018
Katrien Neyrinck, Natacha Breuls, Bryan Holvoet, Wouter Oosterlinck, Esther Wolfs, H Vanbilloen, Olivier Gheysens, Robin Duelen, Willy Gsell, Ivo Lambrichts, Uwe Himmelreich, Catherine M. Verfaillie, Maurilio Sampaolesi, Christophe M. Deroose   +13 more
openalex   +1 more source

Supplementary Data from Specific Targeting of Somatostatin Receptor Subtype-2 for Fluorescence-Guided Surgery

, 2023
Servando Hernandez Vargas, Susanne Kossatz, Julie Voss, Sukhen C. Ghosh, Hop S. Tran Cao, Jo Simien, Thomas Reiner, Sadhna Dhingra, William E. Fisher, Ali Azhdarinia   +9 more
openalex   +1 more source

Controversies in NEN: An ENETS position statement on nutritional support in neuroendocrine neoplasms

Journal of Neuroendocrinology, EarlyView.
Abstract Neuroendocrine neoplasms (NEN) themselves and also their treatment may cause malnutrition, inducing changes in physiological behaviour and eventually leading to increased rates of morbidity and mortality. Malnutrition is a common, under‐recognised and under‐treated condition in patients with NEN, and there are limited data available on the ...
Simona Grozinsky‐Glasberg, Johannes Hofland, Stephanie Alband, Yasmin Chotai de Lima, Adina Croitoru, Wanda Geilvoet, Peter Igaz, Beata Kos‐Kudła, Guenter J. Krejs, Alessandro Laviano, Francesco Panzuto, Anguraj Sadanandam, Ana Paula Santos, Staffan Welin, Rajaventhan Srirajaskanthan, V. Ambrosini, D. K. Bartsch, E. Baudin, N. Begum, E. Christ, J. Cros, T. Denecke, C. M. Deroose, C. Dromain, M. Falconi, N. Fazio, L. Fernandez‐Cuesta, R. Garcia‐Carbonero, A. Grossman, G. Kaltsas, A. Kasajima, A. Kjaer, G. Klöppel, U. P. Knigge, A. Lamarca, S. W. Langer, T. V. Luong, W. Martin, M. McNamara, D. O'Toole, S. Partelli, M. Pavel, A. Perren, R. Salazar, J. Schrader, H. Sorbye, A. Sowa‐Staszczak, E.‐J. Speel, P. Stalberg, M. Tesselaar, E. Tiensuu Janson, M. Tsoli, M. Volante, T. Walter   +53 more
wiley   +1 more source

The Wnt pathway protein Dvl1 targets somatostatin receptor 2 for lysosome-dependent degradation. [PDF]

J Biol Chem, 2023
Carr HS, Zuo Y, Frost JA.
europepmc   +1 more source