Results 171 to 180 of about 38,268 (270)

Fast Interneuron Dysfunction in Laminar Neural Mass Model Reproduces Alzheimer's Oscillatory Biomarkers

Human Brain Mapping, Volume 47, Issue 1, January 2026.
A computational laminar model links fast interneuron dysfunction to early hyperexcitability and late hypoactivity in Alzheimer's disease, reproducing key M/EEG biomarkers and capturing the disease's biphasic electrophysiological progression. ABSTRACT Early‐stage AD involves cortical hyperexcitability, progressing to oscillatory slowing and hypoactivity.
Roser Sanchez‐Todo, Borja Mercadal, Edmundo Lopez‐Sola, Maria Guasch‐Morgades, Gustavo Deco, Giulio Ruffini   +5 more
wiley   +1 more source

Chemotherapy-Induced Upregulation of Somatostatin Receptor-2 Increases the Uptake and Efficacy of ¹⁷⁷Lu-DOTA-Octreotate in Neuroendocrine Tumor Cells. [PDF]

Cancers (Basel), 2021
Shah RG, Merlin MA, Adant S, Zine-Eddine F, Beauregard JM, Shah GM.   +5 more
europepmc   +1 more source

Supplemental Table S2 from Targeting the Somatostatin Receptor 2 with the Miniaturized Drug Conjugate, PEN-221: A Potent and Novel Therapeutic for the Treatment of Small Cell Lung Cancer

, 2023
Kerry A. Whalen, Brian H. White, James M. Quinn, Kristina Kriksciukaite, Rossitza Alargova, Tsun P. Au Yeung, P. Bazinet, Adam Brockman, Michelle DuPont, Haley Oller, James Gifford, Charles-Andre Lemelin, Patrick Lim Soo, Samantha Perino, Benoît Moreau, Gitanjali Sharma, Rajesh Shinde, Beata Sweryda‐Krawiec, Mark T. Bilodeau, Richard Wooster   +19 more
openalex   +1 more source

Diagnostic and Therapeutic Potential of Substance P/NK1 Receptor in Primary Dysmenorrhea: A Pilot Study

Health Science Reports, Volume 9, Issue 1, January 2026.
ABSTRACT Background and Aims Primary dysmenorrhea is a prevalent condition that causes significant menstrual pain and discomfort, impacting many women′s daily activities. The Substance P/NK1 receptor (SP/NK1R) pathway has been linked to the pain mechanisms underlying dysmenorrhea, yet its potential as a therapeutic target remains inadequately explored.
Riffat Mehboob, Imran Shahid, Abdullah R. Alzahrani, Shimaa Mohammad Yousof, Hafsa Adnan, Samar N. Ekram, Ahmad Alwazzan, Hisham Nasief, Khalid A. Khadawardi   +8 more
wiley   +1 more source

Somatostatin receptor 2 expression in nasopharyngeal cancer is induced by Epstein Barr virus infection: impact on prognosis, imaging and therapy. [PDF]

Nat Commun, 2021
Lechner M, Schartinger VH, Steele CD, Nei WL, Ooft ML, Schreiber LM, Pipinikas CP, Chung GT, Chan YY, Wu F, To KF, Tsang CM, Pearce W, Morelli D, Philpott M, Masterson L, Nibhani R, Wells G, Bell CG, Koller J, Delecluse S, Yip YL, Liu J, Forde CT, Forster MD, Jay A, Dudás J, Krapp A, Wan S, Uprimny C, Sprung S, Haybaeck J, Fenton TR, Chester K, Thirlwell C, Royle G, Marafioti T, Gupta R, Indrasari SR, Herdini C, Slim MAM, Indrawati I, Sutton L, Fles R, Tan B, Yeong J, Jain A, Han S, Wang H, Loke KSH, He W, Xu R, Jin H, Cheng Z, Howard D, Hwang PH, Le QT, Tay JK, West RB, Tsao SW, Meyer T, Riechelmann H, Oppermann U, Delecluse HJ, Willems SM, Chua MLK, Busson P, Lo KW, Wollmann G, Pillay N, Vanhaesebroeck B, Lund VJ.   +71 more
europepmc   +1 more source

A novel pathway activated by somatostatin receptor type 2 (SST2): Inhibition of pituitary tumor cell migration and invasion through cytoskeleton protein recruitment [PDF]

, 2017
Erika Peverelli, Elena Giardino, Donatella Treppiedi, Rosa Catalano, Federica Mangili, Marco Locatelli, Andrea Lania, Maura Arosio, A. Spada, Giovanna Mantovani   +9 more
openalex   +1 more source

Mastering Organoid Growth: A Complete Guide to Overcoming Methodological Challenges

MedComm, Volume 7, Issue 1, January 2026.
Organoids offer transformative 3D models that precisely mimic human organ architecture and function. This review details the latest methodology, emphasizing the cultivation of liver and other abdominal organoids. We analyze technological challenges (e.g., nutrient delivery, scalability, diversity) and provide practical insights for new researchers ...
Chunbao Jiao, Omer Faruk Karakaya, Neda Dadgar, Chase J. Wehrle, Zahra Massoud, Hanna Hong, Robert L. Fairchild, Nic Leipzig, Federico Aucejo, Wen Wee Ma, Jan Joseph Melenhorst, Sofia Ferreira Gonzales, Andrea Schlegel   +12 more
wiley   +1 more source

Blocking dopamine receptor 2 decreases gastrin levels in H. pylori-infected mice through increasing gastric somatostatin content

Qun Shen, Yueyue Zhou, Yanlin Wang, Qi Yao, Dongbo Lian, Zhe-Hong Li, Mengfei Chen, Xiaoli Zhang, Yue Zhang, Song Jin, Li‐Fei Zheng, Jin‐Xia Zhu   +11 more
openalex   +1 more source

Supplementary Material for: Detection of abdominal lymph node metastasis from pancreatic neuroendocrine tumor by somatostatin receptor scintigraphy: Comparison with somatostatin receptors type 2 immunostaining

, 2023
Kazuhiro Kitajima, Hideyuki Shiomi, Takako Kihara, Seiko Hirono, Ryosuke Nakano, Takenori J. Okamoto, Chie Yagi, E. J. H., Kana Matsuda, Masahiko Hatano, Mamoru Yoshida, Hiroshi Kono, Seiichi Hirota, Toshiyuki Minami, Koichiro Yamakado   +14 more
openalex   +1 more source

Linking Age Changes in Human Cortical Microcircuits to Impaired Brain Function and EEG Biomarkers

Aging Cell, Volume 25, Issue 1, January 2026.
We integrated human data of aging‐related reductions in inhibition, NMDA function, and dendritic spines into detailed models of cortical microcircuits. Simulations showed that the cellular aging mechanisms accounted for many of the age‐related changes seen in human EEG and could be estimated accurately using machine learning from their EEG biomarkers ...
Alexandre Guet‐McCreight, Shreejoy Tripathy, Etienne Sibille, Etay Hay   +3 more
wiley   +1 more source