The tetraamine chelator outperforms HYNIC in a new technetium-99m-labelled somatostatin receptor 2 antagonist [PDF]
EJNMMI Research, 2018 Background Somatostatin receptor targeting radiopeptides are successfully being used to image, stage, and monitor patients with neuroendocrine tumours. They are exclusively agonists that internalise upon binding to the relevant receptor.
Keelara Abiraj +9 more
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SAT-LB24 Association of Expression of Somatostatin Receptor 2 Subtype in Non-Pituitary Neuroendocrine Tumors With Response to Treatment With Somatostatin Analogues [PDF]
J Endocr Soc, 2020 Siddiqui A +4 more
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A transplantable phosphorylation probe for direct assessment of G protein-coupled receptor activation. [PDF]
PLoS ONE, 2012 The newly developed multireceptor somatostatin analogs pasireotide (SOM230), octreotide and somatoprim (DG3173) have primarily been characterized according to their binding profiles.
Andrea Kliewer +4 more
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Preclinical study of a new 177Lu-labeled somatostatin receptor antagonist in HT-29 human colorectal cancer cells [PDF]
Asia Oceania Journal of Nuclear Medicine and Biology, 2020 Objective(s): Somatostatin receptor-positive neuroendocrine tumors have been targeted using various peptide analogs radiolabeled with therapeutic radionuclides for years.
Hossein Behnammanesh +8 more
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Role of somatostatin receptor-2 in gentamicin-induced auditory hair cell loss in the Mammalian inner ear. [PDF]
PLoS ONE, 2014 Hair cells and spiral ganglion neurons of the mammalian auditory system do not regenerate, and their loss leads to irreversible hearing loss. Aminoglycosides induce auditory hair cell death in vitro, and evidence suggests that phosphatidylinositol-3 ...
Yves Brand +7 more
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Evaluation of somatostatin and nucleolin receptors for therapeutic delivery in non-small cell lung cancer stem cells applying the somatostatin-analog DOTATATE and the nucleolin-targeting aptamer AS1411. [PDF]
PLoS ONE, 2017 Cancer stem cells represent the putative tumor-driving subpopulation thought to account for drug resistance, relapse, and metastatic spread of epithelial and other cancer types.
Sif Holmboe +8 more
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Regulation of Somatostatin Receptor 2 Trafficking by C-Tail Motifs and the Retromer. [PDF]
Endocrinology, 2019 Olsen C +5 more
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Regulation of somatostatin receptor 2 in the context of antidepressant treatment response in chronic mild stress in rat. [PDF]
Psychopharmacology (Berl), 2018 Faron-Górecka A +11 more
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Somatostatin Receptor Subtype Expression in Patients with Acromegaly and Complicated Clinical Course
Diagnostics, 2021 Somatostatin analogues are considered to be the first line of treatment in acromegaly. Somatostatin analogues of the first generation mainly target the somatostatin receptor (SSTR) subtype 2 and have been proven efficient in the majority of patients with
Robert Pichler +5 more
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Peptide Radioligands in Cancer Theranostics: Agonists and Antagonists
Pharmaceuticals, 2023 The clinical success of radiolabeled somatostatin analogs in the diagnosis and therapy—“theranostics”—of tumors expressing the somatostatin subtype 2 receptor (SST2R) has paved the way for the development of a broader panel of peptide radioligands ...
Berthold A. Nock +4 more
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