Results 201 to 210 of about 38,268 (270)

Discovery of novel 5-oxa-2,6-diazaspiro[3.4]oct-6-ene derivatives as potent, selective, and orally available somatostatin receptor subtype 5 (SSTR5) antagonists for treatment of type 2 diabetes mellitus

, 2017
Hideki Hirose, Takeshi Yamasaki, Masaki Ogino, Ryo Mizojiri, Yumiko Tamura-Okano, Hiroaki Yashiro, Yo Muraki, Yoshihide Nakano, Jun Sugama, Akito Hata, Shinji Iwasaki, Masanori Watanabe, Tsuyoshi Maekawa, Shizuo Kasai   +13 more
openalex   +1 more source

Medical Management of Polycystic Liver Disease: A Position Statement From the European Reference Network on Hepatological Diseases

Liver International, Volume 46, Issue 1, January 2026.
ABSTRACT Polycystic liver disease (PLD) is a rare genetic disorder characterised by progressive liver enlargement due to multiple cysts. The main symptoms are liver volume‐related. Although randomised controlled trials have shown that somatostatin analogues (SSAs) reduce liver volume as well as symptoms, specific guidance on when and how to use SSAs in
Sophia Heinrich, Andreia Margarida Carvalho de Matos, Jordi Colmenero, Ahmed M. Elsharkawy, Soňa Fraňková, Jan Halbritter, Anna Mrzljak, Roman‐Ulrich Müller, Rafaela Pereira, Pavel Strnad, Carmen A. J. Teemer, Jef Verbeek, Karolina M. Wronka, Frederik Nevens, Richard Taubert, Joost P. H. Drenth, on behalf of the European Reference Network on Hepatological Liver Diseases (ERN RARE‐LIVER)   +16 more
wiley   +1 more source

Enhancing the anti-tumour activity of ¹⁷⁷Lu-DOTA-octreotate radionuclide therapy in somatostatin receptor-2 expressing tumour models by targeting PARP. [PDF]

Sci Rep, 2020
Cullinane C, Waldeck K, Kirby L, Rogers BE, Eu P, Tothill RW, Hicks RJ.   +6 more
europepmc   +1 more source

Inhibitory circuit motifs of cortical somatosensory layer 5 SST interneurons are uniform within layers but specific across layers

The Journal of Physiology, Volume 604, Issue 1, Page 479-502, 1 January 2026.
Abstract figure legend In our study we wanted to discover inhibitory circuits targeting layer 5 (L5) somatostatin (SST)‐expressing neurons. As putative presynaptic cells we chose parvalbumin (PV) and vasoactive intestinal polypeptide (VIP)‐expressing interneurons (IN). Previous studies showed that in L2/3 SST IN are targeted by PV and VIP cells.
Felix Preuss, Florian Walker, Martin Möck, Mirko Witte, Jochen F. Staiger   +4 more
wiley   +1 more source

DOTATATE Scan in Meningiomatosis in a Patient With Ophthalmoplegia

Case Reports in Ophthalmological Medicine, Volume 2026, Issue 1, 2026.
DOTATATE (1,4,7,10‐tetraazacyclododecane‐1,4,7,10‐tetraacetic acid [DOTA]‐octreotate) is a compound that binds somatostatin receptors seen in tumors such as meningiomas. Here, we present a case of a patient with progressive bilateral ophthalmoplegia due to meningiomatosis involving both cavernous sinuses, which was highlighted by DOTATATE imaging. Some
Joshua Pasol, Carolina G. Benjamin, W. David Honeycutt, Cristiano Giusti   +3 more
wiley   +1 more source

Prolonged Somatostatin Receptor 2 Antagonism Enhances Glucagon Response to Hypoglycemia in Male Diabetic Rats.

Endocrinology
D'Souza NC, Aleali N, Shakeri D, Atherley SC, Hoffman EG, Karimi Chahartash S, Javanbakhsh S, Chan O, Liggins RT, Riddell MC.   +9 more
europepmc   +1 more source

Discovery of substituted (4-phenyl-1H-imidazol-2-yl)methanamine as potent somatostatin receptor 3 agonists

, 2015
Zhong Lai, Shuwen He, Edward C. Sherer, Zhicai Wu, Yang Yu, Richard Ball, Qingmei Hong, David Yang, Liangqing Guo, Derun Li, Quang Tuang, Gary G. Chicchi, Dorina Trusca, Kwei‐Lan Tsao, Yunping Zhou, Andrew D. Howard, Ravi P. Nargund, William K. Hagmann   +17 more
openalex   +1 more source

Phytochemical Profiling, Anthocyanin Characterization, and In Vivo Evaluation of the Hypoglycemic Activity of Clitoria ternatea L. Flower Extract Cultivated in Vietnam

Journal of Food Biochemistry, Volume 2026, Issue 1, 2026.
This study evaluated the hypoglycemic potential of a concentrated extract obtained from Clitoria ternatea extract (CTE), collected from Tay Ninh Province, Vietnam. The extract was obtained by aqueous extraction and characterized using LC–HRMS, revealing the presence of several bioactive compounds, including delphinidin derivatives, kaempferol 3‐(6′‐p ...
Kha Duyen Nguyen, Ngọc Anh Le, Thi Anh Dao Dong, Thi Thu Tra Tran, Anupama Bose   +4 more
wiley   +1 more source

Prevalence and Clinical Correlations of Somatostatin Receptor-2 (SSTR2) Expression in Neuroblastoma. [PDF]

J Pediatr Hematol Oncol, 2019
Alexander N, Marrano P, Thorner P, Naranjo A, Van Ryn C, Martinez D, Batra V, Zhang L, Irwin MS, Baruchel S.   +9 more
europepmc   +1 more source

Bidirectional Regulation of NLRP3 Inflammasome and Mitochondrial Quality Control in Sepsis: Mechanisms and Therapeutic Implications

Mediators of Inflammation, Volume 2026, Issue 1, 2026.
Characterized by its capacity to induce organ failure, sepsis constitutes a life‐threatening pathological state with high incidence and mortality rates. Current treatments primarily focus on antimicrobial therapy and organ support, lacking direct interventions targeting the restoration of cellular or organelle function.
Xiangxin Liao, Yixun Wang, Zhaohui Zhang, Xingguang Qu, Gaosheng Zhou, Laurent L′homme   +5 more
wiley   +1 more source