Results 231 to 240 of about 38,268 (270)

Somatostatin Receptor Type 2 (SSTR2) in Bronchopulmonary Carcinoids

Endocrine Pathology, 2010
To the Editors: Bronchopulmonary carcinoids (BCs) are uncommon neuroendocrine tumours, accounting for no more than 2% of all primary lung malignancies. BCs are generally regarded as benign or low-grade neoplasms, with atypical carcinoids (AC) being associated with a worse prognosis than the typical variant (TC) [1]. Surgical removal is the first choice
FASSAN, MATTEO, REA, FEDERICO, CLEMENTE R, RIZZARDI G, PIZZI M, GIACOMELLI, LUCA, RUGGE, MASSIMO   +6 more
openaire   +2 more sources

Somatostatin-14 Mainly Binds the Somatostatin Receptor Subtype 2 in Human Neuroblastoma Tumors

Neuroendocrinology, 1996
Neuroblastoma is a pediatric cancer for which a cure is elusive for most children with disseminated disease. Neuroblastomas possess receptors for somatostatin (SS). Some SS analogues can inhibit their proliferation. In addition, when SS analogues were used as agents for scintigraphy, neuroblastoma tumor sites can be localized with high efficiency.
G, Prevost, N, Veber, C, Viollet, V, Roubert, P, Roubert, J, Benard, P, Eden   +6 more
openaire   +2 more sources

Role of Somatostatin and Somatostatin Receptor type 2 in Postincisional Nociception in Rats

Neuropeptides, 2015
Somatostatin (SST) and the somatostatin receptor type 2 (sstr2) are expressed in the superficial part (Laminae I-III) of the dorsal horn of the spinal cord. Since the neurons in these laminae also receive nociceptive sensation from the periphery, it was hypothesized that both SST and sstr2 could be involved in the modulation of nociceptive transmission.
Pranav Prasoon, Rahul Kumar, Mayank Gautam, Ebin K. Sebastian, K.H. Reeta, Subrata Basu Ray   +5 more
openaire   +2 more sources

Splice variant of the somatostatin receptor 2 subtype, somatostatin receptor 2B, couples to adenylyl cyclase.

Molecular Pharmacology, 1993
The diverse biological actions of somatostatin (SRIF) are mediated by a family of receptors, of which five have been cloned and characterized. One of the SRIF receptor subtypes, SSTR2, has been shown to exist in two forms. SSTR2A and SSTR2B are 369 and 346 amino acids in size, respectively, and differ in length and amino acid sequence in their ...
T, Reisine, H, Kong, K, Raynor, H, Yano, J, Takeda, K, Yasuda, G I, Bell   +6 more
openaire   +2 more sources

Molecular Cloning and Sequencing of Porcine Somatostatin Receptor 2+

Biochemical and Biophysical Research Communications, 1994
The porcine somatostatin receptor gene was isolated from a porcine genomic library. Based on the deduced amino acid sequence, this gene encodes a 369 amino acid protein with seven hydrophobic segments, a characteristic of G-protein coupled receptors, and shows only 13 amino acid difference (identity 96.5%, similarity 99.2%) in amino acid sequence from ...
K, Matsumoto, Y, Yokogoshi, Y, Fujinaka, C, Zhang, S, Saito   +4 more
openaire   +2 more sources

Somatostatin receptor-2 negative meningioma: pathologic correlation and imaging implications

Clinical Imaging, 2020
Meningiomas are the most common non-malignant primary intracranial tumors, accounting for nearly 40% of all primary brain tumors, usually expressing high levels of somatostatin receptors (SSTR), particularly SSTR2. Because 68Ga-DOTATATE targets SSTR2, it is increasingly used clinically for meningioma evaluation.
Michelle, Roytman, David J, Pisapia, Benjamin, Liechty, Eaton, Lin, Myrto, Skafida, Rajiv S, Magge, Joseph R, Osborne, Susan C, Pannullo, Jonathan P S, Knisely, Rohan, Ramakrishna, Jana, Ivanidze   +10 more
openaire   +2 more sources

Somatostatin Receptor Subtypes in Human Type 2 Diabetic Islets

Pancreas, 2010
Somatostatin inhibits hormone release through 5 G protein-coupled somatostatin receptors (sst1-sst5). However, the role of somatostatin in islet physiology is not fully known. The immunoreactivity to sst1 to sst5 in normal human endocrine pancreas has been described.
Guida M, Portela-Gomes, Lars, Grimelius, Per, Westermark, Mats, Stridsberg   +3 more
openaire   +2 more sources

Somatostatin Inhibition of Acid and Histamine Release by Activation of Somatostatin Receptor Subtype 2 Receptors in Rats

The Journal of Pharmacology and Experimental Therapeutics, 1997
Peptide analogs of somatostatin with relatively selective binding affinities for specific somatostatin receptor subtypes, including SMS-201-995 [somatostatin receptor subtype (sst)2, sst3 and sst5], NC-8-12 (sst2), BIM-23058 (sst3) and BIM-23052 (sst5), were administered i.v. to anesthetized rats to determine the somatostatin receptor subtypes involved
K, Aurang, J, Wang, K C, Lloyd
openaire   +2 more sources

Somatostatin receptor subtype 2 mediates somatostatin inhibition of ion secretion in rat distal colon

Gastroenterology, 1996
Somatostatin peptides are potent inhibitors of intestinal ion secretion, providing the rationale for their use in treating secretory diarrhea. However, the nature of the receptors that mediate these effects is unclear. The aims of this study were to investigate expression of somatostatin receptor subtypes (SSTRs) 1-5 in rat colonic epithelium and to ...
G, Warhurst, N B, Higgs, H, Fakhoury, A C, Warhurst, J, Garde, D H, Coy   +5 more
openaire   +2 more sources

Role of somatostatin receptors on gastric acid secretion in wild-type and somatostatin receptor type 2 knockout mice

Naunyn-Schmiedeberg's Archives of Pharmacology, 2004
Somatostatin, probably acting through somatostatin type 2 receptors (SSTR2), is the main inhibitor of gastric acid secretion. We characterized gastric acid secretion in SSTR2 knockout mice, and used preferential somatostatin receptor agonists to assess the relative role of SSTR1, 2, 3, 4, and 5 on gastric acid secretion.
Laura, Piqueras, Vicente, Martínez
openaire   +2 more sources