Results 241 to 250 of about 69,057 (285)

Somatostatin receptor 2 signaling promotes growth and tumor survival in small-cell lung cancer. [PDF]

Int J Cancer, 2019
Lehman JM, Hoeksema MD, Staub J, Qian J, Harris B, Callison JC, Miao J, Shi C, Eisenberg R, Chen H, Chen SC, Massion PP.   +11 more
europepmc   +1 more source

Neocortical neurogenesis: a proneural gene perspective

The FEBS Journal, Volume 292, Issue 21, Page 5580-5610, November 2025.
The neocortex is a mammalian‐specific brain region responsible for higher‐order cognitive functioning that shares fundamental similarities across species, but which is larger and more complex in humans. Proneural genes, encoding basic helix–loop–helix transcription factors (TFs), are evolutionarily conserved drivers of neurogenesis from fly to human ...
Lakshmy Vasan, Alexandra Moffat, Pierre Mattar, Carol Schuurmans   +3 more
wiley   +1 more source

Crosstalk Between Astrocytes and Inhibitory Neurons During Maturation: Emerging Mechanisms and Functional Implications

Journal of Neurochemistry, Volume 169, Issue 11, November 2025.
In this review, we discuss the development and maturation of inhibitory neurons and astrocytes and how early developmental activity in the brain might promote the interactions between these cell types. Early in development, excitatory neurons are the first to emerge.
Niina Lehti Tauriala, Vered Kellner
wiley   +1 more source

Cyclooxygenase-2 up-regulates hepatic somatostatin receptor 2 expression. [PDF]

Sci Rep, 2018
Lu YY, Gao JH, Zhao C, Wen SL, Tang CW, Wang YF.   +5 more
europepmc   +1 more source

Cell Type‐Specific mTORC1 Signaling and Translational Control in Synaptic Plasticity and Memory

Journal of Neurochemistry, Volume 169, Issue 11, November 2025.
The formation of long‐term memories depends on de novo protein synthesis, a process tightly regulated by the mechanistic/mammalian target of rapamycin complex 1 (mTORC1) signaling pathway. mTORC1 plays a central role in promoting mRNA translation in the central nervous system.
Ziying Huang, Niaz Mahmood, Shane Wiebe, Arkady Khoutorsky, Jean‐Claude Lacaille, Nahum Sonenberg   +5 more
wiley   +1 more source

Regulation of somatostatin receptor 2 by proinflammatory, microbial and obesity-related signals in periodontal cells and tissues. [PDF]

Head Face Med, 2019
Memmert S, Damanaki A, Nokhbehsaim M, Nogueira AVB, Eick S, Cirelli JA, Jäger A, Deschner J.   +7 more
europepmc   +1 more source

Local Protein Synthesis at Synapses: A Driver for Synapse Diversification

Journal of Neurochemistry, Volume 169, Issue 11, November 2025.
Local protein synthesis is abundant in neuronal processes. This localized translation of mRNA is believed to allow neurons to rapidly modify synaptic strength in response to activity. We review mechanisms guiding mRNA transport into dendrites and axons, emphasizing their selective recruitment for translation during synaptic plasticity.
Ezgi Daskin, Stanley Van, Anne‐Sophie Hafner   +2 more
wiley   +1 more source

The expression of somatostatin receptor 2 decreases during cyst growth in mice with polycystic kidney disease. [PDF]

Exp Biol Med (Maywood), 2018
Lin C, Lin C, Happé H, Veraar K, Scharpfenecker M, Peters DJ, Dipak Consortium.   +6 more
europepmc   +1 more source

Tumor‐infiltrating immune cells predict the response to somatostatin receptor ligands only in somatotropinomas naïve to medical therapy

Journal of Neuroendocrinology, Volume 37, Issue 11, November 2025.
Abstract Tumor‐infiltrating immune cells (TICs) are important components of the tumor microenvironment (TME). They regulate somatotroph adenoma treatment responses to therapy with somatostatin receptor ligands (SRLs), mediated by soluble factors and cytokines. In this study, we assessed the effect of SRLs treatment on TICs.
Sabrina Chiloiro, Alessandra Vicari, Antonella Giampietro, Pier Paolo Mattogno, Natalia Cappoli, Greis Konini, Rosalinda Calandrelli, Liverana Lauretti, Simona Gaudino, Mario Rigante, Guido Rindi, Alessandro Olivi, Laura De Marinis, Antonio Bianchi, Francesco Doglietto, Marco Gessi, Alfredo Pontecorvi   +16 more
wiley   +1 more source

Quality of life as a predictor for survival in patients with small intestinal neuroendocrine tumours

Journal of Neuroendocrinology, Volume 37, Issue 11, November 2025.
Abstract Health‐related quality of life (HRQoL) has been shown to predict overall survival (OS) in several different malignancies, but not in patients with small intestinal neuroendocrine tumours (siNET). We evaluated the influence of HRQoL on survival in patients with siNET. We included 85 patients with advanced siNET who completed the validated HRQoL
Håkan Ohlsson, Martin Nilsson, Anna Sundlöv, Marlene Malmström, Martin Almquist   +4 more
wiley   +1 more source