Results 21 to 30 of about 38,268 (270)

Cyclooxygenase-2 up-regulates hepatic somatostatin receptor 2 expression. [PDF]

Sci Rep, 2018
AbstractSomatostatin and its analogues, which function by binding to somatostatin receptors (SSTRs) 1–5, play a protective role in liver cirrhosis. Hepatic SSTR-2 expression is up-regulated in subjects with liver cirrhosis. However, little is known about the mechanisms underlying this process.
Lu YY, Gao JH, Zhao C, Wen SL, Tang CW, Wang YF.   +5 more
europepmc   +4 more sources

Somatostatin Receptor Subtype Expression in Patients with Acromegaly and Complicated Clinical Course

Diagnostics, 2021
Somatostatin analogues are considered to be the first line of treatment in acromegaly. Somatostatin analogues of the first generation mainly target the somatostatin receptor (SSTR) subtype 2 and have been proven efficient in the majority of patients with
Robert Pichler, Ognian Kalev, Berndt Tomancok, Michael Sonnberger, Daniela Ehrlich, Marina Hodolic   +5 more
doaj   +1 more source

Peptide Radioligands in Cancer Theranostics: Agonists and Antagonists

Pharmaceuticals, 2023
The clinical success of radiolabeled somatostatin analogs in the diagnosis and therapy—“theranostics”—of tumors expressing the somatostatin subtype 2 receptor (SST2R) has paved the way for the development of a broader panel of peptide radioligands ...
Berthold A. Nock, Panagiotis Kanellopoulos, Lieke Joosten, Rosalba Mansi, Theodosia Maina   +4 more
doaj   +1 more source

Detection of Abdominal Lymph Node Metastasis from Pancreatic Neuroendocrine Tumor by Somatostatin Receptor Scintigraphy: Comparison with Somatostatin Receptor Type 2 Immunostaining

Case Reports in Oncology, 2023
We report a 58-year-old male with a histopathologically proven grade 2 (G2) pancreatic neuroendocrine neoplasm and multiple abdominal node metastases by use of a laparoscopic pancreatic body and tail resection procedure, plus abdominal lymph node ...
Kazuhiro Kitajima, Hideyuki Shiomi, Takako Kihara, Seiko Hirono, Ryota Nakano, Tomohiro Okamoto, Chisako Yagi, Hirotsugu Eda, Kosuke Matsuda, Michiko Hatano, Makoto Yoshida, Hiroshi Kono, Seiichi Hirota, Tetsuya Minami, Koichiro Yamakado   +14 more
doaj   +1 more source

Regulation of somatostatin receptor 2 in the context of antidepressant treatment response in chronic mild stress in rat. [PDF]

Psychopharmacology (Berl), 2018
Faron-Górecka A, Kuśmider M, Solich J, Kolasa M, Pabian P, Gruca P, Romańska I, Żurawek D, Szlachta M, Papp M, Antkiewicz-Michaluk L, Dziedzicka-Wasylewska M.   +11 more
europepmc   +3 more sources

Somatostatin Subtype-2 Receptor-Targeted Metal-Based Anticancer Complexes [PDF]

Bioconjugate Chemistry, 2012
Conjugates of a dicarba analogue of octreotide, a potent somatostatin agonist whose receptors are overexpressed on tumor cells, with [PtCl(2)(dap)] (dap = 1-(carboxylic acid)-1,2-diaminoethane) (3), [(η(6)-bip)Os(4-CO(2)-pico)Cl] (bip = biphenyl, pico = picolinate) (4), [(η(6)-p-cym)RuCl(dap)](+) (p-cym = p-cymene) (5), and [(η(6)-p-cym)RuCl(imidazole ...
Flavia Barragán, Dolors Carrion-Salip, Irene Gómez-Pinto, Alejandro González-Cantó, Peter J. Sadler, Rafael de Llorens, Virtudes Moreno, Carlos González, Anna Massaguer, Vicente Marchán   +9 more
openaire   +6 more sources

Positive somatostatin receptor scintigraphy correlates with the presence of somatostatin receptor subtype 2. [PDF]

Gut, 1996
Somatostatin receptor scintigraphy (SRS) is positive in approximately 75% of all patients with neuroendocrine gastroenteropancreatic tumours. This study aimed to identify specific somatostatin receptor (sstr) subtypes, which are responsible for the in vivo binding of the widely used somatostatin analogue, octreotide in human neuroendocrine ...
M, John, W, Meyerhof, D, Richter, B, Waser, J C, Schaer, H, Scherübl, J, Boese-Landgraf, P, Neuhaus, C, Ziske, K, Mölling, E O, Riecken, J C, Reubi, B, Wiedenmann   +12 more
openaire   +2 more sources

Preoperative detection of functional somatostatin receptors in a patient with an insulinoma

Clinical Case Reports, 2023
Key Clinical Message Octreotide is used in patients with insulinomas to treat hypoglycemia, and somatostatin receptor (SSTR) 2 expression is important for its efficacy. We report a case of insulinoma in a 50‐year‐old woman that responded to an octreotide
Kohei Oguni, Shinnosuke Fukushima, Yukichika Yamamoto, Kou Hasegawa, Hideharu Hagiya, Naoko Inoshita, Fumio Otsuka   +6 more
doaj   +1 more source

Regulation of Somatostatin Receptor 2 Trafficking by C-Tail Motifs and the Retromer. [PDF]

Endocrinology, 2019
Olsen C, Memarzadeh K, Ulu A, Carr HS, Bean AJ, Frost JA.   +5 more
europepmc   +2 more sources

Somatostatin receptor expression in parathyroid neoplasms

Endocrine Connections, 2019
Introduction: Parathyroid carcinoma represents a rare cause of primary hyperparathyroidism. Distinguishing carcinoma from the benign tumors underlying primary hyperparathyroidism remains challenging.
Sara Storvall, Helena Leijon, Eeva Ryhänen, Johanna Louhimo, Caj Haglund, Camilla Schalin-Jäntti, Johanna Arola   +6 more
doaj   +1 more source