Results 31 to 40 of about 38,268 (270)
Contemporary nuclear medicine diagnostics of neuroendocrine tumors [PDF]
Srpski Arhiv za Celokupno Lekarstvo, 2015 The new positron emission tomography (PET/CT) methods for neuroendocrine tumors detection are presented and compared with classic, conventional methods. Conventional methods use a gamma scintillation camera for patients with neuroendocrine tumor
Todorović-Tirnanić Mila +4 more
doaj +1 more source
OR23-05 Human Absorption, Metabolism, Excretion, and Absolute Oral Bioavailability of 14C-CRN00808, an Orally Bioavailable, Nonpeptide, Selective, Somatostatin Receptor 2 (sST2) Biased Agonist for the Treatment of Acromegaly [PDF]
J Endocr Soc, 2020 Madan A +5 more
europepmc +2 more sources
Homologous and Heterologous Regulation of Somatostatin Receptor 2 [PDF]
Molecular Endocrinology, 2002 AbstractWe previously demonstrated that phosphorylation of somatostatin receptor 2A (sst2A) is rapidly increased in transfected cells both by agonist and by the protein kinase C (PKC) activator phorbol myristate acetate (PMA). Here, we investigate whether PKC-mediated receptor phosphorylation is involved in the homologous or heterologous regulation of ...
Gerard, Elberg +2 more
openaire +2 more sources
PLoS ONE, 2014 Albumin fusion technology, the combination of small molecular proteins or peptides with human serum albumin (HSA), is an effective method for improving the medicinal values of natural small molecular proteins or peptides.
Ying Peng +7 more
doaj +1 more source
Somatostatin-Somatostatin Receptor 2 Signaling Mediates LH Pulse Suppression in Lactating Rats [PDF]
Endocrinology, 2018 Follicular development and ovulation are profoundly suppressed during lactation in mammals. This suppression is suggested to be mainly due to the suckling-induced inhibition of kisspeptin gene (Kiss1) expression in the arcuate nucleus (ARC) and consequent inhibition of pulsatile GnRH/LH release.
Arisa Sugimoto +6 more
openaire +2 more sources
Frontiers in Endocrinology, 2022 IntroductionWe present a case of a patient with disseminated ACTH-secreting neuroendocrine neoplasm with biologic heterogeneity between a primary tumor and metastases.
Daria Ryzhkova +4 more
doaj +1 more source
Membrane-displayed somatostatin activates somatostatin receptor subtype-2 heterologously produced in Saccharomyces cerevisiae [PDF]
AMB Express, 2012 Abstract The G-protein-coupled receptor (GPCR) superfamily, which includes somatostatin receptors (SSTRs), is one of the most important drug targets in the pharmaceutical industry. The yeast Saccharomyces cerevisiae is an attractive host for the ligand screening of human GPCRs.
Hara, Keisuke +3 more
openaire +2 more sources
Intra-Islet Somatostatin Regulates Glucagon Release via Type 2 Somatostatin Receptors in Rats [PDF]
Diabetes, 2003 Exogenously administered somatostatin (SST) inhibits secretion of insulin and glucagon. Furthermore, it is hypothesized that islet SST regulates glucagon secretion by a local action. A number of studies utilizing SST antibodies have been performed to test this hypothesis, and their results have been conflicting.
Kenan, Cejvan +2 more
openaire +2 more sources
The somatostatinergic system in the mammalian cochlea
BMC Neuroscience, 2011 Background Little is known about expression and function of the somatostatinergic system in the mammalian cochlea. We have previously shown that somatostatin administration may have a protective effect on gentamicin-induced hair cell loss. In this study,
Kapfhammer Josef P +5 more
doaj +1 more source
Investigative Opthalmology & Visual Science, 2008 To define the molecular pharmacology underlying the antiangiogenic effects of nonpeptide imidazolidine-2,4-dione somatostatin receptor agonists (NISAs) and evaluate the efficacy of NISA in ocular versus systemic delivery routes in ocular disease models.Functional inhibitory effects of the NISAs and the somatostatin peptide analogue octreotide were ...
Stela S, Palii +13 more
openaire +2 more sources