Results 41 to 50 of about 410 (178)

ZDHHC17‐Mediated CDK4 Palmitoylation Drives Cell Cycle Progression and Orchestrates Cancer Immune Surveillance

Advanced Science, EarlyView.
ZDHHC17 palmitoylates CDK4, which together with TRAF6‐mediated ubiquitination, drives cell cycle progression and immune surveillance, revealing a rational combination of CDK4 inhibitors with immune checkpoint blockers for ZDHHC17‐driven cancers. ABSTRACT Uncontrolled cell cycle progression is a hallmark of cancer, tightly regulated by both intrinsic ...
Zekang Wang, Peipei Song, Xueji Wu, Lei Wang, Wei Xie, Pinning Feng, Chao Cheng, Jianping Guo   +7 more
wiley   +1 more source

Radiation‐Induced Tumor‐Intrinsic LTβR N‐Glycosylation Suppresses Pyroptosis Through TRIM28‐Mediated PCBP2 SUMOylation to Promote Gastric Cancer Radioresistance

Advanced Science, EarlyView.
Radiotherapy triggers LTβR N‐glycosylation, enhancing its overall protein stability and nuclear retention. This accumulation drives TRIM28‐mediated PCBP2 SUMOylation, suppressing pyroptosis and conferring gastric cancer radioresistance. Therapeutically, a targeted nanoplatform (cRGD‐Lipo@EMD) effectively disrupts this regulatory axis, offering a highly
Weijie Zang, Yunlong Ji, Chunwang Zhou, Xiwen Li, Zhuang Lu, Guangze Zhang, Yu Chen, Wanjiang Xue, Yilin Hu   +8 more
wiley   +1 more source

Numerical analysis of stagger Supersonic biplane at off-design condition with trailing edge flap [PDF]

FME Transactions, 2023
Supersonic biplanes can achieve low-boom and low-drag supersonic flights. In the present study, aerodynamic analysis of a two-dimensional stagger Bussmann biplane (staggered upper element by 0.5c) at zero degrees angle of attack with trailing edge flap ...
Patidar Vijay Kumar, Joshi Sudhir
doaj  

Integrative Omics Analysis Reveals the Regulation of Hypoxia Tolerance in Large Yellow Croaker (Larimichthys crocea) via the Lipoic Acid Synthase (lias) Gene

Advanced Science, EarlyView.
Lipoic acid synthase (lias) can regulate α‐KG levels through lipoylation, thereby negatively regulating HIF‐1α protein levels via PHD under hypoixa. The Hap2 allele of lias exhibits lower expression levels than Hap1, leading to the accumulation of more HIF‐1α protein and thereby enhancing hypoxia tolerance. ABSTRACT Hypoxia stress seriously affects the
Jie Ding, Songpeng Jia, Ran Meng, Xuelei Wang, Xiongfei Wu, Weiliang Shen, Yibo Zhang, Junquan Zhu   +7 more
wiley   +1 more source

Sonic Boom Impact Assessment of European SST Concept for Milan to New York Supersonic Flight

Acoustics
This study presents a surrogate modeling framework designed for the rapid yet reliable assessment of sonic boom impacts. The methodology is demonstrated through two case studies: a transatlantic flight from Milan to New York, highlighting the sonic boom ...
Giovanni Fasulo, Antimo Glorioso, Francesco Petrosino, Mattia Barbarino, Luigi Federico   +4 more
doaj   +1 more source

Development of a sustainable water treatment process using biochar as substrate for filtration and coliform removal

The Canadian Journal of Chemical Engineering, EarlyView.
Preparation, modification, and characterization of biochar from woodchips and its application in stream water filtration, evaluated through physicochemical and microbiological analyses. Abstract Global microbial water contamination affects 1.8 billion people, necessitating efficient and sustainable treatment methods.
Tariq Khalil, Muhammad Ishtiaq Ali, Rameesha Abid, Anab Mujtaba, Rabia Asghar, Asif Jamal, Yusuf Tutar, Ahsan Habib, Fakhraddin Yusubov   +8 more
wiley   +1 more source

SONEMUS Fest (2015–2018): From ‘Sonic Boom’ to ‘Icarus’

INSAM, 2018
SONEMUS is an organization established in 2001 for the purpose of performing, promoting and educating in the domain of contemporary music. The SONEMUS Festival is the only festival of its kind in Bosnia and Herzegovina and that is the reason for its ...
Rijad Kaniža
doaj   +1 more source

Sprayable Polyolefin Sorbents Enabled by Bio‐Solvents for Large‐Scale Oil and Chemical Spill Recovery

ENERGY &ENVIRONMENTAL MATERIALS, EarlyView.
A sprayable POE‐based sorbent formulated with a green solvent blend of α‐pinene, D‐limonene, and p‐cymene enables rapid in situ film formation via solvent evaporation, allowing efficient pollutant capture. The system exhibits high oil uptake (37.3 g g−1) and effectively removes up to 60 mL of VLSFO under simulated marine spill conditions.
Youngmin Choi, Changwoo Nam
wiley   +1 more source

Comparison of Prediction Models for Sonic Boom Ground Signatures Under Realistic Flight Conditions

Aerospace
This paper presents a comparative analysis of simplified and high-fidelity sonic boom prediction methods to assess their applicability in the conceptual design of supersonic aircraft. The high-fidelity approach combines Computational Fluid Dynamics (CFD)
Jacob Jäschke, Samuele Graziani, Francesco Petrosino, Antimo Glorioso, Volker Gollnick   +4 more
doaj   +1 more source

First genome sequence of a European Alternaria brassicae isolate and genes involved in early development of alternaria leaf spot on Brassica juncea

Pest Management Science, EarlyView.
This article reports the first genome sequence of a UK Alternaria brassicae isolate. Dual RNA‐sequencing profiling of A. brassicae‐infected Brassica juncea leaves identified differentially expressed genes involved in pathogenicity and host response pathways in moderately resistant Sej‐2 (2) and moderately susceptible Pusa Jaikisan cultivars.
Kevin M. King, Graham McLaughlin, Chinthani S. Karandeni Dewage, Zedi Gao, David J. Hughes, Jonathan S. West, Henrik U. Stotz   +6 more
wiley   +1 more source