Results 141 to 150 of about 116,918 (241)

Human iPSC‐Derived Brain Organoids: A Disease‐Oriented Evaluation of Modeling Fidelity

European Journal of Neuroscience, Volume 64, Issue 5, September 2026.
Organoids are self‐organizing 3D structures that mimic organ architecture and function with multiple cell types arranged in spatial patterns. Brain organoids can be patterned towards specific regions and can incorporate glial and microglial components.
Bishwa R. Pokharel, Abigail Dickerson, Sanjana G. Shenoy, Mira S. Ramasamy, Niska Majumdar, Paul P. Cook, Shaw M. Akula   +6 more
wiley   +1 more source

Light- and chemical-induced ciliary signaling governs dorsal/ventral regionalization of human telencephalic organoids

Nature Communications
Neural stem/progenitor cells (NPCs) have primary cilia, which are critical organelles for Sonic hedgehog signaling. However, little is known about the components of primary cilia in NPCs and whether manipulating signaling in the cilia is sufficient to ...
Issei S. Shimada, Akari Goto, Yutaka Hashimoto, Hajime Inoue, Takuto Sugawara, Tomohiro Doura, Tsubasa Fujita, Toshiaki Iwata, Riko Shimmoto, Hiroshi Takase, Masayuki Itoh, Shigeki Kiyonaka, Yoichi Kato   +12 more
doaj   +1 more source

The Therapeutic Potential of Purmorphamine Across Disease Models

Journal of Cellular and Molecular Medicine, Volume 30, Issue 17, September 2026.
ABSTRACT Purmorphamine (PUR) is a trisubstituted purine compound that selectively activates Smoothened receptor, thereby initiating Sonic Hedgehog (Shh) signalling—a pathway critical for embryonic patterning, neuronal specification and tissue regeneration across multiple organ systems. Dysregulation of Shh signalling has been implicated in degenerative
Ashis Dhar, Ahnaf Dil Sharar, Saikarthik Papisetty, Mohammad Bydon, F. M. Moinuddin   +4 more
wiley   +1 more source

Meet the Editorial Team. An interview with Angelo Iulianella, Assistant Editor, Dalhousie University Faculty of Medicine, Canada

Developmental Dynamics, Volume 255, Issue 9, Page 842-844, September 2026.
Paul Trevorrow, Angelo Iulianella
wiley   +1 more source

Molecular Mediators Associated With Myelination, Demyelination, and Remyelination in the Peripheral Nervous System

Journal of the Peripheral Nervous System, Volume 31, Issue 3, September 2026.
ABSTRACT The peripheral nervous system (PNS) is responsible for innervating all regions of the body outside of the central nervous system (CNS), the latter consisting of the brain, spinal cord, and optic nerves. While myelin is an essential component for the efficient functioning of both CNS and peripheral nerve cells, it is particularly important for ...
Kathleen Margaret Hagen, Shalina Sheryl Ousman   +1 more
wiley   +1 more source

Sonic hedgehog antagonists induce cell death in acute myeloid leukemia cells with the presence of lipopolysaccharides, tumor necrosis factor-alpha, or interferons

, 2014
Due to the development of drug resistance, the outcome for the majority of patients with acute myeloid leukemia (acute myelogenous leukemia; AML) remains poor.
Lu, Frank Leigh;Yu, Ching-Chia;Chiu, Huei-Hsuan;Liu, Hsingjin Eugene;Chen, Shao-Yin;Lin, Shufan;Goh, Ting-Yi;Hsu, Hsin-Chih;Chien, Chih-Han;Wu, Han-Chung;Chen, Ming-Shan;Schuyler, Scott C.;Hsieh, Wu-Shiun;Wu, Mei-Hwan;Lu, Jean, 謝武勳 ;吳美環 ;呂立   +1 more
core  

Spaceborne and spaceborn: Physiological aspects of pregnancy and birth during interplanetary flight

Experimental Physiology, Volume 111, Issue 9, Page 4015-4040, 1 September 2026.
Abstract Crewed interplanetary return missions that are on the planning horizon will take years, more than enough time for initiation and completion of a pregnancy. Pregnancy is viewed as a sequence of processes – fertilization, blastocyst formation, implantation, gastrulation, placentation, organogenesis, gross morphogenesis, birth and neonatal ...
Arun V. Holden
wiley   +1 more source

Gene therapy, angiogenesis, Sonic Hedgehog: Sonic The Hedgehog to the rescue? [PDF]

Gene Therapy, 2006
openaire   +1 more source

RXR Gamma Enables Oligodendrocyte Differentiation by Suppressing Sonic Hedgehog Signaling. [PDF]

Glia
Baldassarro VA, Brassart Q, Fraulob V, Calzà L, Krezel W.   +4 more
europepmc   +1 more source

Mechanical Suppression of Sonic Hedgehog Signaling by Nucleus Pulposus Cells Underlies Early Disc Degeneration in Mouse. [PDF]

Cells
Virk S, Shah V, Piprode V, Kemp CM, Alluri H, Vincent KF, Krishnan R, Hong J, Albert TJ, Dahia CL.   +9 more
europepmc   +1 more source