Results 161 to 170 of about 61,899 (269)

Diprosopus dirrhinus (nasal duplication) in a female Holstein Friesian calf: Clinical findings, diagnostic imaging and surgical management

Veterinary Record Case Reports, Volume 14, Issue 2, May 2026.
Abstract An 11‐week‐old Holstein Friesian heifer calf presented with a congenital nasal abnormality characterised by an additional, turbinate‐like structure located dorsally on the nasal bridge. Clinical examination of the calf revealed normal respiratory function, with the accessory structure producing mucoid discharge from blind‐ended cavities ...
Raffaela Marian, Michael J. S. Duggan, Clodagh M. Kearney, Antonella Puggioni, Eoin G. Ryan   +4 more
wiley   +1 more source

Interleukin‐10 Derived Apoptotic Vesicles Enhance Scarless Skin Healing by Modulating Fibroblast Metabolism and Fibrosis Pathways

Cell Proliferation, Volume 59, Issue 5, May 2026.
IL10_ApoEVs, generated during IL‐10‐induced fibroblast apoptosis, reprogram fibroblast metabolism and inhibit fibrosis to promote scarless skin healing. By enhancing mitochondrial OXPHOS, suppressing glycolysis, and downregulating Hedgehog signaling, IL10_ApoEVs shift collagen deposition toward regenerative type III collagen, offering a novel strategy ...
Yang Zou, Jinglun Zhang, Wenxuan Mao, Shuting Jiang, Cheng Xu, Jiayi Meng, Heng Dong, Yongbin Mou   +7 more
wiley   +1 more source

The Critical Role of GALNTs‐Regulated O‐GalNAc Glycosylation in Cancer Malignancy

The FASEB Journal, Volume 40, Issue 8, 30 April 2026.
The GALNT family initiates mucin‐type O‐GalNAc glycosylation in the Golgi apparatus and how regulatory mechanisms, including GALNT relocalization and microRNA control, modulate this process. Dysregulated O‐GalNAc glycosylation alters key cellular behaviors and promotes cancer malignancy, highlighting its relevance to tumor progression as well as its ...
Jiahao Liu, Sihan Wu, Ge Zhang, Jiehan Li, Yuhan Yin, Aman Uiiah, Sanfei Peng, Yang Fu   +7 more
wiley   +1 more source

Sonic Hedgehog Protein [PDF]

, 2020
openaire   +1 more source

RaMBat: Accurate identification of medulloblastoma subtypes from diverse data sources with severe batch effects

Molecular Oncology, Volume 20, Issue 4, Page 1074-1089, April 2026.
To integrate multiple transcriptomics data with severe batch effects for identifying MB subtypes, we developed a novel and accurate computational method named RaMBat, which leveraged subtype‐specific gene expression ranking information instead of absolute gene expression levels to address batch effects of diverse data sources.
Mengtao Sun, Jieqiong Wang, Shibiao Wan
wiley   +1 more source

siRNA Delivery via Cross‐Linked Gelatin Microparticles Enables Targeted Modulation of Osteogenic‐Vascular Cross‐Talk: An Advanced Human 3D in Vitro Test System for Therapeutic siRNA

Advanced Healthcare Materials, Volume 15, Issue 13, 3 April 2026.
Osteogenic‐angiogenic cross‐talk is a vital prerequisite for vascularized bone regeneration. In this study, we investigated the effects of siRNA‐mediated silencing of two inhibitory proteins, Chordin and WWP‐1, via CaP‐NP‐loaded gelatin microparticles in osteogenically differentiated microtissues.
Franziska Mitrach, Jonas Kubat, Stefan Simm, Alexandra H. Springwald, Burak Demir, Anton Liebezeit, Michael C. Hacker, Michaela Schulz‐Siegmund   +7 more
wiley   +1 more source

Peptide‐Incorporated Biomaterials Promote Regeneration of Peripheral Nerve Injuries

Advanced Science, Volume 13, Issue 23, 23 April 2026.
Peptide‐incorporated biomaterials provide precise, tunable biological cues that mimic functional protein domains to regulate behaviors of neurons, Schwann cells, immune cells, and endothelial cells, thereby enhancing axon elongation, Schwann cell support, inflammatory microenvironment modulation, and vascularization, offering a promising alternative to
Zhiwei Zhao, Jianfeng Liu, Jincheng Li, Di Li, Jianxun Ding, Bin Liu   +5 more
wiley   +1 more source

Genotypes and Phenotypes of Patients With TSPEAR‐Related Disorder: Evidence of a Predominant Dental Phenotype

American Journal of Medical Genetics Part A, Volume 200, Issue 4, Page 790-799, April 2026.
ABSTRACT TSPEAR (chr. 21q22.3) encodes a protein involved in tooth development and is predominantly expressed in the enamel knot. Biallelic loss of function variants in TSPEAR cause ectodermal dysplasia, tooth agenesis and sensorineural hearing loss. However, the role of TSPEAR in auditory processes is unclear.
Debora Vergani, Lucia Tiberi, Annarita Giliberti, Elia Dirupo, Laila Zaroili, Francesco Brancati, Michela Brena, Stefano Caraffi, Chiara De Luca, Livia Garavelli, Anna Virginia Gulino, Milena Mariani, Marzia Pollazzon, Angelo Selicorni, Samuela Landini, Ilaria Sani, Rosangela Artuso, Angela Peron   +17 more
wiley   +1 more source

Significance of Early Proton Beam Therapy Initiation in Achieving Complete Response in Pediatric Medulloblastoma: A Retrospective Study

Cancer Medicine, Volume 15, Issue 4, April 2026.
ABSTRACT Introduction Proton beam therapy (PBT) has proven to be highly effective in treating pediatric medulloblastoma, offering both excellent therapeutic outcomes and reduced side effects. However, factors influencing tumor response following PBT remain poorly defined, including the optimal interval time between surgery and PBT initiation (ISP ...
Zhipeng Shen, Zhuo Hou, Wei Han, Yi Zhang, Weiling Zhang, Shuihua Wu, Jianfeng Liang, Chen Jiang, Zishen Wang, Wei Wang, Shuyan Zhang, Hideyuki Sakurai, Shosei Shimizu (Qingshui Xiangxing)   +12 more
wiley   +1 more source

Metastatic Basal Cell Carcinoma With Unusual Molecular Genetics Findings

Clinical Case Reports, Volume 14, Issue 4, April 2026.
ABSTRACT Basal cell carcinoma (BCC) rarely metastasizes to other parts of the body. When metastasis occurs, it usually involves regional lymph nodes. BCC lesions located in the head and neck region have been shown to spread to cervical lymph nodes.
Noora Al‐Hail, Majid Al‐Abdulla, Syed Rizvi, Nazeeha Al‐Hayki   +3 more
wiley   +1 more source