Results 171 to 180 of about 61,899 (269)

Electroacupuncture Modulates Multiple Pathways for Neuroprotection and Neurorepair in Ischemic Stroke

CNS Neuroscience &Therapeutics, Volume 32, Issue 4, April 2026.
EA exerts therapeutic effects in ischemic stroke through multiple mechanisms: it alleviates acute injury by suppressing neuroinflammation, excitotoxicity, oxidative stress, apoptosis, pyroptosis, ferroptosis, autophagy dysregulation, and blood–brain barrier disruption, while enhancing cerebral blood flow, angiogenesis, and neurogenesis to support ...
Mingyue Zhao, Hangyu Shen, Xu Yan, Xiang Gao, Yuchun Liu, Shengjun Zhou, Jingxian Sun, Jie Sun, Yi Huang   +8 more
wiley   +1 more source

Heterogeneity of Sonic Hedgehog response dynamics and fate specification in single neural progenitors. [PDF]

Elife
Xiong F, Tentner AR, Nandagopal S, Hiscock TW, Huang P, Tsung-Megason SG.   +5 more
europepmc   +1 more source

Leveraging extracellular vesicle biology for novel tests and therapeutics for kidney fibrosis

Clinical and Translational Medicine, Volume 16, Issue 4, April 2026.
Extracellular vesicles (EVs) are bilipid membrane‐encased nanoparticles that play critical roles as cell‐to‐cell messengers and waste management mechanisms. EVs cargos can be leveraged as biomarkers to develop minimally invasive tests for kidney fibrosis and guide personalised mechanism‐driven care.
Chin‐Ya Sophie Chiang, Andrew J. Kassianos, Helen Grania Healy, Monica Suet Ying Ng   +3 more
wiley   +1 more source

RETRACTION: Resveratrol Downregulates Interleukin-6-Stimulated Sonic Hedgehog Signaling in Human Acute Myeloid Leukemia. [PDF]

Evid Based Complement Alternat Med
And Alternative Medicine EC.
europepmc   +1 more source

Cytopathologic Features of Metastatic Malignant Mesothelioma With SMARCB1 (INI‐1) Deficient Diagnosed by Ultrasound‐Guided Fine‐Needle Aspiration: A Case Report

Diagnostic Cytopathology, Volume 54, Issue 4, Page E87-E92, April 2026.
ABSTRACT Malignant mesothelioma (MM) is a rare yet aggressive neoplasm that arises from mesothelial cells lining the thoracic and abdominal cavities, the pericardium, and the tunica testis. Characterized by rapid progression, high invasiveness, and a poor prognosis, MM poses significant clinical challenges. SMARCB1, also referred to as INI‐1, hSNF5, or
Jun Yang, Juandi Liu, Jing Jin, Deng Pan, Lei Shao   +4 more
wiley   +1 more source

GRIA1 regulates TGN export and secretion of Sonic hedgehog. [PDF]

J Biol Chem
Tang X, Tian Y, Wang Q, Song Z, Zhao X, Guo Y.   +5 more
europepmc   +1 more source

Localized Delivery of a Small Molecule Hedgehog Agonist via Poly(ε‐caprolactone) Scaffolds Enhances Tendon‐to‐Bone Integration

Journal of Orthopaedic Research, Volume 44, Issue 4, April 2026.
ABSTRACT Tendon and ligament injuries often require surgery, with successful recovery, whether direct repair of a torn tendon to bone or reconstruction of ligaments, requiring effective tendon‐to‐bone integration. Unfortunately, re‐tear rates can be high, demonstrating the need for improved treatment strategies. The Hedgehog (Hh) pathway is critical to
Jonathan Marcelin, Rashad Madi, Timur B. Kamalitdinov, Xi Jiang, Dong Hwa Kim, Robert L. Mauck, Andrew F. Kuntz, Nathaniel A. Dyment   +7 more
wiley   +1 more source

Liquid–Liquid Phase Separation in Viral Infection and Immunology

MedComm, Volume 7, Issue 4, April 2026.
LLPS organizes viral replication and antiviral immunity. Viruses hijack LLPS to form replication factories and evade immune sensors, while hosts assemble LLPS‐driven signaling hubs (e.g., MAVS, RIG‐I, and SGs) to amplify interferon responses. Targeting these condensate interfaces offers novel therapeutic strategies against infectious diseases ...
Jiuzhi Xu, Lan Bai, Bin Wang, Hai Song, Long Zhang, Fangfang Zhou   +5 more
wiley   +1 more source

Gene therapy, angiogenesis, Sonic Hedgehog: Sonic The Hedgehog to the rescue? [PDF]

Gene Therapy, 2006
openaire   +1 more source

7,7"-dimethoxyagastisflavone induced MYCN/MYBL2-dependent apoptosis and metabolism reprogramming in Sonic Hedgehog medulloblastoma. [PDF]

J Transl Med
Wu YS, Lin HH, Wu KS, Huang YT, Liao JY, Chu SS, Wong TT, Hsieh CL, Chang CC, Sung SY, Lin CY, Lin YL.   +11 more
europepmc   +1 more source