Results 41 to 50 of about 2,042 (179)

A narrow bandgap Schottky heterojunction Fe2N/CeO2 microneedle triggering sonodynamic reactive oxygen species storm for drug‐resistance‐free skin fungal infection

BMEMat, EarlyView.
Inorganic sonosensitizers suffer from inefficient electron‐hole separation, rapid recombination, and wide bandgaps in anti‐fungal applications. We propose MN@Fe2N/CeO2 to directly eliminate fungi without drug resistance. Combining semiconductor CeO2's advantages with Fe2N's high work function and activity enables efficient Schottky heterojunctions ...
Li Wang, Jiayi Yang, Ning Tang, Youbin Zheng, Yichao Hou, Chutong Liu, Lihao Guo, Yingying Liao, Gandong Zhou, Weiwei Wu, Xin Du, Shuxiang Xu, Jie Yin, Miaomiao Yuan   +13 more
wiley   +1 more source

Evaluation of a rhenium glycosylated complex as sonosensitizer for inactivation of E. coli in vitro

Bacterial infections pose a threat to public health worldwide with the emergence of antibiotic-resistant strains. Moreover, current antibiotics are proving to have limited efficacy against resistant pathogens, and newer antibiotics are scarce. Therefore,
Jha, Abhishek, Jagaanal, Anu, Kerai, Roshni, Gupta, Iti, Das, Manita, Bhatia, Dhiraj, Mistry, Nishita, Shekhar, Himanshu   +7 more
core   +1 more source

Bacterial backpacks for targeted delivery of piezoelectric nanoparticles to enhance sonodynamic immunotherapy

BMEMat, EarlyView.
Leveraging bacterial hypoxia targeting, KBTO NPs accumulate at the tumor site. Under the ultrasound irradiation, KBTO NPs produce reactive oxygen species to kill tumor cells and eliminate bacteria, preventing overgrowth and inflammation. The lysed bacteria act as antigens to trigger antitumor immunity and further enhanced by the immune checkpoint ...
Chongyang Liu, Haohui Zhu, Huaibin Yu, Xijun Zhang, Zhiqin Lei, Wenjing Xu, Xinyu Zhao, Ming Wu, Long Yang, Juanjuan Liu, Zhengbao Zha, Xinghui Si, Jianjun Yuan   +12 more
wiley   +1 more source

Long-Circulating Au-TiO₂ Nanocomposite as a Sonosensitizer for ROS-Mediated Eradication of Cancer

, 2016
Although sonodynamic therapy (SDT) has emerged as a potential alternative to conventional photodynamic therapy, the low quantum yield of the sonosensitizer such as TiO2 nanoparticles (NPs) is still a major concern.
Kwangmeyung Kim (457840), Wooram Um (2574901), Seunglee Kwon (2690230), Doo Sung Lee (1547686), Dong Gil You (2574904), Gi-Ra Yi (1364106), Hyewon Ko (1659898), Ick Chan Kwon (457841), Jae Hyung Park (1659892), Ki Young Choi (1320180), V. G. Deepagan (3187863), Jun Young Lee (249366)   +11 more
core   +1 more source

Antitumor Effects of Pegylated Zinc Protoporphyrin-Mediated Sonodynamic Therapy in Ovarian Cancer

, 2023
Sonodynamic therapy (SDT) induces reactive oxygen species (ROS) to kill tumor cells. Heme oxygenase-1 (HO-1), as an important antioxidant enzyme, resists killing by scavenging ROS.
Jia Li, Xin Lin, Guixiang Lv, Zheng Hu, Xu Gao, Jiwei Zhu   +5 more
core   +1 more source

From pathogen to “living drug factory” innovative strategies and clinical translation of bacteria as programmable intelligent vectors for cancer therapy

BMEMat, EarlyView.
Engineered bacteria serve as smart, living therapeutics that target tumors, deliver drugs, and remodel immunosuppressive microenvironments. This review highlights their potential to potentiate immunotherapy, radiotherapy, and chemotherapy, offering a promising paradigm for precise and synergistic cancer treatment. Abstract The dynamic interplay between
Haonan Shen, Weichen Zhang, Gaoli Niu, Li Wang, Ruiyan Li, Yueyue Fan, Feixue Lu, Lingling Xu, Xiaoyuan Ji, Yong Kang   +9 more
wiley   +1 more source

Fluorinated Chitosan To Enhance Transmucosal Delivery of Sonosensitizer-Conjugated Catalase for Sonodynamic Bladder Cancer Treatment Post-intravesical Instillation

, 2020
Sonodynamic therapy (SDT) is a noninvasive ultrasound-triggered therapeutic strategy for site-specific treatment of tumors with great depth penetration.
Shan Gao (46743), Zhuang Liu (551357), Shupeng Wang (551358), Guangzhi Li (1457872), Enpu Zhang (8422578), Qifang Lei (8422572), Dashi Deng (8422566), Guixiao Huang (8422575), Zhong Wen (2981073), Ziliang Dong (1425994), Zhiping Wang (38478), Guohua Zeng (288129), Song Wu (36667), Zhisheng Xiao (8422569)   +13 more
core   +1 more source

Ginsenoside Rk1-Loaded Manganese-Doped Hollow Titania for Enhancing Tumor Sonodynamic Therapy via Upregulation of Intracellular Reactive Oxygen Species

, 2023
Amplifying the intracellular reactive oxygen species (ROS) level remains an urgent challenge for efficient sonodynamic therapy (SDT) of tumors. Herein, by loading ginsenoside Rk1 with manganese-doped hollow titania (MHT), a Rk1@MHT sonosensitizer was ...
Ming Yang (109148), Aiguo Wu (315321), Ming Yang, Xiaoxia Wu, Chunshu Pan, Qiongyu Qin (15331497), Qiongyu Qin, Aiguo Wu, Xiaopeng Qi (266069), Chunshu Pan (9681389), Wenzhi Ren, Weihao Zhu, Haijing Cui, Qiuye Wang (199423), Haijing Cui (15331494), Qiuye Wang, Xiaopeng Qi, Wenzhi Ren (232747), Weihao Zhu (7026167), Xiaoxia Wu (671551)   +19 more
core   +1 more source

Channel‐trap coupled charge modulation in sulfur‐vacancy‐rich nanotransducer for enhanced dual‐mode cancer catalytic therapy

BMEMat, EarlyView.
Sulfur vacancy‐rich ZnS–NCx heterojunctions are engineered as dual‐function nanotransducers, in which channel‐trap‐coupled electronic pathways enable efficient capture and transport of ultrasound‐induced piezoelectrons. This vacancy‐mediated regulation simultaneously enhances sonodynamic activity and biomimetic POD/GSHOx catalysis, triggering a self ...
Songjing Zhong, Zeyu Zhang, Wenting Chen, Quanhong Hu, Hongyi Sun, Ruidong Yin, Qinyu Zhao, Hongbo Fan, Yuanbo Cui, Yuxuan Zhang, Linlin Li   +10 more
wiley   +1 more source

Engineering Bacteria for Medicine: Delivery, Diagnosis, and Therapy

iMetaMed, EarlyView.
ABSTRACT With rapid advances in synthetic biology and genetic engineering, genetically engineered bacteria (GEB) have emerged as a promising platform for biological therapy, addressing key limitations of conventional drug delivery systems and demonstrating significant clinical potential.
Shiyu Xia, Guiling Fu, Xiaoyue Ding, Wen Yang, Ruijie Bai, Yawei Cai, Jing xuan Zhang, Yanxia Wei, Conghui Han, Yi‐Zhou Gao, Ying Li, Zuobin Zhu   +11 more
wiley   +1 more source