Results 41 to 50 of about 1,400 (162)

Microbubbles Ultrasonic Cavitation Regulates Tumor Interstitial Fluid Pressure and Enhances Sonodynamic Therapy

Frontiers in Oncology, 2022
Sonodynamic therapy (SDT) is a promising treatment method for solid tumors. However, the high interstitial fluid pressure (IFP) in tumor tissues limits the accumulation of sonosensitizers. In the present study, microbubbles ultrasonic cavitation was used
Fen Xi, Fen Xi, Fen Xi, Yuyi Feng, Yuyi Feng, Qiaoli Chen, Qiaoli Chen, Liping Chen, Liping Chen, Jianhua Liu, Jianhua Liu, Jianhua Liu   +11 more
doaj   +1 more source

2D Nano‐Sonosensitizers Facilitate Energy Transfer to Enhance Sonodynamic Therapy

Advanced Materials, 2023
AbstractAlthough sonodynamic therapy (SDT) has shown promise for cancer treatment, the lack of efficient sonosensitizers (SSs) has limited the clinical application of SDT. Here, a new strategy is reported for designing efficient nano‐sonosensitizers based on 2D nanoscale metal–organic layers (MOLs).
Gan Lin, Geoffrey T. Nash, Taokun Luo, Indranil Ghosh, Siddhartha Sohoni, Andrew J. Christofferson, Gang Liu, Gregory S. Engel, Wenbin Lin   +8 more
openaire   +3 more sources

Multimodal Actuation and Environment Adaptive Strategies of Bio‐Inspired Micro/Nanorobots in Precision Medicine

Advanced Robotics Research, EarlyView.
An introduction for multidrive and environment‐adaptive micro/nanorobotics: design and fabrication strategies, intelligent actuation, and their applications. Various intelligent actuation approaches—magnetic, acoustic, optical, chemical, and biological—can be synergistically designed to enhance flexibility and adaptive behavior for precision medicine ...
Aiqing Ma, Han Gong, Jiacheng Ouyang, Liqi Chen, Tianfang Kang, Yiran He, Guojun Huang, Sidi Zheng, Ting Yin, Hong Pan, Lintao Cai   +10 more
wiley   +1 more source

Development and characteristics of novel sonosensitive liposomes for vincristine bitartrate [PDF]

Drug Delivery, 2019
The aim of drug delivery is to increase therapeutic efficacy. Externally triggered drug delivery systems enable site-specific and time-controlled drug release. To achieve this goal, our strategy was based on ultrasound-triggered release of an anticancer agent from sonosensitive liposomes (SL).
Wen Lin, Xiaoxing Ma, Chaopei Zhou, Hong Yang, Yang Yang, Xiangyang Xie, Chunrong Yang, Cuiyan Han   +7 more
openaire   +3 more sources

Ultrasound‐Boosted Liposomal Prodrug Overcomes Age‐Associated Biodistribution Disparity in Pediatric Solid Tumor Therapy

Advanced Science, EarlyView.
The age‐associated disparity of nanocarrier biodistribution limits the nanotherapeutics of childhood solid tumors. This study developed an ultrasound‐activated liposomal prodrug (CSCPTL) to overcome the age‐associated disparity of off‐target distribution.
Danfei Chen, Junjun Xu, Jian Chen, Jue Hu, Xiaobo Xuan, Haifang Cai, Mingdong Yang, Zhuxian Zhou, Guowei Wang   +8 more
wiley   +1 more source

Composite materials for multimodal sonodynamic therapy in biomedical applications

Next Materials
Sonodynamic therapy (SDT) presents significant advantages, such as improved tissue penetration, non-invasiveness, and reduced susceptibility to drug resistance, positioning it as a promising modality in the biomedical domain.
Min Ma, Lili Luo, Yuxuan Ding, Jiayi Zuo, Xiaofen Chai, Libing Liu   +5 more
doaj   +1 more source

Aptamer‐Engineered Liposomal Platform Enables in Situ cDC1 Vaccination to Potentiate Immunotherapy in Prostate Cancer

Advanced Science, EarlyView.
Prostate cancer is immunologically ‘cold’, with scarce, dysfunctional type 1 conventional dendritic cells (cDC1s) that limit T cell priming. We introduce an aptamer‐targeted liposomedelivering FMS‐like tyrosine kinase 3 ligand (Flt3L) and chlorin e6 (Ce6). Ultrasound induces antigen release and cDC1s recruitment, creating an in situ cDC1 vaccine.
Jiayi Wang, Xuan Wang, Xinfeng Dai, Linxin Tian, Wencheng Shen, Xueliang Liu, Wei Xue, Jiahua Pan, Yu Yang   +8 more
wiley   +1 more source

Transformable Tumor Microenvironment‐Responsive Oxygen Vacancy‐Rich MnO2@Hydroxyapatite Nanospheres for Highly Efficient Cancer Sonodynamic Immunotherapy

Advanced Science
Despite the promise of sonodynamic therapy (SDT)‐mediated immunotherapy, the anticancer efficacy of current sonosensitizers is greatly limited by the immunosuppressive tumor microenvironment (TME) and their inability to selectively respond to it. Herein,
Minxing Li, Qiyu Liu, Songzuo Xie, Desheng Weng, Jinjun He, Xinyi Yang, Yuanyuan Liu, Jinqi You, Jinghao Liao, Peng Wang, Xihong Lu, Jingjing Zhao   +11 more
doaj   +1 more source

Nanostructured TiO2 cavitation agents for dual-modal sonophotocatalysis with pulsed ultrasound

Ultrasonics Sonochemistry, 2021
Current sonochemical methods rely on spatially uncontrolled cavitation for radical species generation to promote chemical reactions. To improve radical generation, sonosensitizers have been demonstrated to be activated by cavitation-based light emission (
U.S. Jonnalagadda, X Su, J.J. Kwan
doaj   +1 more source

Defect‐Rich 2D Layered Double Hydroxides Enhance Sonodynamic Antibacterial Therapy

Advanced Science, EarlyView.
This study develops defect‐rich ultrathin ZnCuW‐LDH nanosheets (DR‐ZnCuW‐LDH) via acid etching. DR‐ZnCuW‐LDH exhibits fourfold enhanced US‐triggered ROS production due to oxygen defects and electronic modulation, demonstrating potent antibacterial efficacy in vitro/vivo.
Qian Liu, Yu Yang, Rui Zhao, Linwei Huang, Xingyu Qi, Min Wu, Jianliang Shen   +6 more
wiley   +1 more source