Results 171 to 180 of about 70,416 (256)

Cost-effectiveness of tremelimumab plus durvalumab versus sorafenib for unresectable hepatocellular carcinoma in China: an economic evaluation based on five-year overall survival data from the HIMALAYA trial. [PDF]

Front Public Health
Feng R, Liang P, Wang Y, Li D, Jia H, Zheng Y, Huo L, Lv Q.   +7 more
europepmc   +1 more source

Engineering Photothermal Nanoplatforms for Multimodal Theranostics and Biosensing

Rare Metals, Volume 45, Issue 10, October 2026.
ABSTRACT Photothermal platforms bridge materials science and biomedicine, emerging as a transformative frontier in biomedical applications. They offer spatiotemporally precise, noninvasive modalities with cell‐type‐independent efficacy for treating a range of diseases.
Xiao Han, Peng Jin, Haiqing Wang, Hao Xue   +3 more
wiley   +1 more source

Sorafenib-loaded porphyrin-phospholipid liposomes for enhanced chemophototherapy in hepatocellular carcinoma. [PDF]

RSC Adv
Tian M, Wang J, Gao M, Xia C, Xiao J, Zhao Y, Han B, Lei N, Huang S, Xie B, He L, Wang F, Ma S, Qin B.   +13 more
europepmc   +1 more source

A Three‐Dimensional Culture–Drug Sensitivity Test Predicts MDM2 Inhibitor–Sensitivity in SMARCB1/INI1‐Deficient Tumors

Cancer Science, Volume 117, Issue 10, Page 2852-2862, October 2026.
This study aimed to determine whether personalized selection of effective drugs for SMARCB1/INI1‐deficient tumors is feasible using in vitro drug sensitivity profiling. Drug sensitivity was assessed using a short‐term collagen gel–embedded three‐dimensional drug sensitivity test (3D‐DST) in tumors derived from SMARCB1/INI1‐deficient tumor cell line ...
Hiroaki Goto, Chiyoko Nishime, Takashi Ohtsu, Mieko Ito, Maiko Sagisaka, Takuya Naruto, Norihiko Kitagawa, Mio Tanaka, Masakatsu Yanagimachi, Yukihiko Hiroshima, Junko Takita, Yasuhide Hayashi, Yohei Miyagi   +12 more
wiley   +1 more source

Development of an Electro-Responsive Sorafenib-Loaded Polypyrrole Coating-Modified Nickel-Titanium Alloy for Tumor Ablation Therapy. [PDF]

J Funct Biomater
Liu L, Gu P, Xia D, Wen Y, Li B, Wang D, Wu Y.   +6 more
europepmc   +1 more source

FDX1 Depletion Activates CD8+ T Cell Antitumor Immunity by Promoting DMBT1 Secretion in Cuproptosis of Colorectal Cancer

Cancer Science, Volume 117, Issue 10, Page 2659-2675, October 2026.
Elesclomol‐induced cuproptosis potently activates both innate and adaptive antitumor immunity, especially CD8+ T cell immunity. FDX1 serves as a central regulator of CD8+ T cell functionality through DMBT1 downregulation during cuproptosis in colorectal cancer.
Jieqiong Wu, Zaixi Lian, Mingzhou Li, Xingtu Qin, Xiaoyu Lei, Lihua Yang, Lin Bing, Qiuyue Li, Lingyan Zhou, Zhiyang Ma, Xuemei Xu, Jinghao Huang, Zilong Chen, Lijie Chen, Lingjie Zhang, Zhiyuan Xiao, Xiangyu Jian, Xiaoqin Zhang, Yanqing Ding, Yaping Ye, Li Liang, Hongli Jiao, Shuyang Wang   +22 more
wiley   +1 more source

HIF1α-KLF4 signaling dictates extra-erythrocyte expression of hemoglobin conferring sorafenib resistance in hepatocellular carcinoma. [PDF]

Signal Transduct Target Ther
Zhang B, Liu F, Gao X, Zhu Y, Chen T, Hao J, Wei Y, Sun Z, Yang R, Yang Y, Ren H, Li Y, Yu C, Ren T, Huang Y, Jiang H, Melino G, Ma L, Huang H, Sun Q.   +19 more
europepmc   +1 more source

Indole‐3‐Propionic Acid Drives Dendritic H3K27 Acetylation to Enhance CD8+ T Cell Immunity in Hepatocellular Carcinoma

Cancer Science, Volume 117, Issue 10, Page 2705-2718, October 2026.
The gut microbiota metabolite indole ‐ 3 ‐ propionic acid（IPA) enhanced the inhibitory effect of SCB on tumor growth in HCC mice. IPA upregulated IL‐12A expression through facilitating acetylation of H3K27 in DCs. IPA elevated IL‐12A expression in DCs to promote CD8+ T cell anti‐tumor immunity and ultimately enhances the efficacy of SCB therapy against
Rui Zhao, Siqi Liu, Qian Zhang, Wenrui Wang, Lanlan Yang, Xue Shao, Shengnan Jia, Zhenjing Jin   +7 more
wiley   +1 more source

Development and Validation of an LC-MS/MS Method for Simultaneous Quantification of Pazopanib, Cabozantinib, Sorafenib, Axitinib, Tivozanib, Sunitinib, and the Metabolites Sorafenib N-Oxide and Desethyl-Sunitinib in Human Plasma. [PDF]

Pharmaceuticals (Basel)
Greibe E, Henriksen JN, Fristrup N, Hoffmann-Lücke E.   +3 more
europepmc   +1 more source

Lysosome‐Targeted Squaramide Anion Transporters

Chemistry – A European Journal, Volume 32, Issue 36, 24 September 2026.
Lysosome‐targeted squaramide anion transporters elicit different biological effects depending on the targeting group employed. ABSTRACT Targeting anion transporters to specific organelles has previously been shown to be an effective strategy to enhance their cytotoxicities against cancerous cell lines.
Elba Feo, Edward York, Anthony Thai, William G. Ryder, Daniel A. McNaughton, Philip A. Gale   +5 more
wiley   +1 more source