Results 1 to 10 of about 4,825 (166)

Study of the Potential Endocrine-Disrupting Effects of Phenylurea Compounds on Neurohypophysis Cells In Vitro [PDF]

International Journal of Endocrinology, 2019
Homeostatic disruptor agents, and endocrine disruptor compounds (EDC) specifically, can originate from agricultural and industrial chemicals. If they modify the adaptation of living organisms as direct (e.g., by altering hormone regulation, membrane ...
Krisztián Sepp, Zsolt Molnár, Anna M. László, Tünde Alapi, László Tóth, Andrea Serester, Zsuzsanna Valkusz, Márta Gálfi, Marianna Radács   +8 more
doaj   +8 more sources

Substructure-activity relationship studies on antibody recognition for phenylurea compounds using competitive immunoassay and computational chemistry. [PDF]

Sci Rep, 2018
AbstractBased on the structural features of fluometuron, an immunizing hapten was synthesized and conjugated to bovine serum albumin as an immunogen to prepare a polyclonal antibody. However, the resultant antibody indicated cross-reactivity with 6 structurally similar phenylurea herbicides, with binding activities (expressed by IC50 values) ranging ...
Zhang F, Liu B, Liu G, Zhang Y, Wang J, Wang S.   +5 more
europepmc   +6 more sources

Design, Synthesis and Insecticidal Activity of Novel Phenylurea Derivatives [PDF]

Molecules, 2015
A series of novel phenylurea derivatives were designed and synthesized according to the method of active groups linkage and the principle of aromatic groups bioisosterism in this study.
Jialong Sun, Yuanming Zhou
doaj   +4 more sources

Current-use and legacy pesticides in canal waters of Chiang Mai, Thailand, during longan flowering and fruit set: occurrence and ecological and human health risk assessment [PDF]

Scientific Reports
This study investigated the occurrence of pesticides, their ecological risks, and potential human health implications in irrigation–drainage canals of Chiang Mai’s longan orchards during two phenological stages: flowering and easrly fruit development. In
Patchimaporn Udomkun, Thidarat Rupngam, Margaret Graham, Thirasant Boonupara, Puangrat Kaewlom   +4 more
doaj   +2 more sources

Design, Synthesis, Molecular Docking, and Anticancer Activity of Chalcone Derivatives as VEGFR-2 Inhibitors [PDF]

Molecules
A series of 4-phenylurea chalcones (2a–2s) as VEGFR-2 inhibitors has been designed, synthesized, and evaluated for in vitro cytotoxic activity against K562, SiHa, and B16 cancer cells.
Mingjun Yu, Xin Zhang, Hui Zhu, Xiaoqian Zhang   +3 more
doaj   +2 more sources

Novel pyrimidine-piperazine hybrids as potential antimicrobial agents: in-vitro antimicrobial and in-silico studies

Results in Chemistry, 2023
A series of new pyrimidine-piperazine hybrid molecules ware designed and synthesized as possible antimicrobial agents. The synthesized compounds (20 derivatives) were characterized using 1HNMR, 13C NMR, MS and elemental analysis and then the activity of ...
Swathi Rejinthala, Srinivas Endoori, Divya Vemula, Vasundhra Bhandari, T. Mondal   +4 more
doaj   +1 more source

On the Thermal Dissociation of Organic Compounds. XII. The Effects of the Substituents on the Thermal Dissociation of Substituted Phenylureas [PDF]

Bulletin of the Chemical Society of Japan, 1957
Abstract Eleven new ureas of the type, 1,1-diethyl-3-arylureas and 1-pentyl-3-arylureas were synthesized. The rate constants and ρ values of thermal dissociation of these ureas in fatty acids were determined. In 1,1-diethyl-3-arylureas, the ρ value of the dissociation reaction at 95°C.
Shoichiro Ozaki, Tsutomu Nagoya
openaire   +1 more source

Rational Design, Synthesis and Cytotoxic Activity of N-(Phenylcarbamoyl)Benzamide on HeLa Cell Lines

Journal of Mathematical and Fundamental Sciences, 2020
Urea derivatives are extensively used in the pharmaceutical industry. However, the unsatisfactory level of their membrane penetration requires further modification of the structures with stronger lipophillic properties. Phenylurea has a phenyl group that
Bambang Tri Purwanto, Siswandono Siswandono, Suko Hardjono, Dian Triwidiandany   +3 more
doaj   +1 more source

Design and synthesis of novel ureido and thioureido conjugated hydrazone derivatives with potent anticancer activity

BMC Chemistry, 2022
Background Compounds possessing urea/thiourea moiety have a wide range of biological properties including anticancer activity. On the other hand, taking advantage of the low toxicity and structural diversity of hydrazone derivatives, they are presently ...
Nasrin Nassiri Koopaei, Mehrasa Shademani, Nasrin Shirzad Yazdi, Raheleh Tahmasvand, Mina Dehbid, Mansur Nassiri Koopaei, Homa Azizian, Zahra Mousavi, Ali Almasirad, Mona Salimi   +9 more
doaj   +1 more source

Evaluation of the Binding Properties of A New Phenylurea Appended Carbazole Compound to Pepsin/Trypsin by Computational and Multi-Spectral Analysis

Journal of Fluorescence, 2023
Abstract A novel carbazole compound, named 1-(9-ethyl-9H-carbazol-3-yl)-3-phenylurea (Cpu) was synthesized and its binding properties with protease enzymes (pepsin and trypsin) has been examined by steady-state fluorescence measurements, UV/vis absorption, infrared (FT-IR) and circular dicroism (CD) spectroscopies and also computational methods.
GÖKOĞLU, ELMAS, Taskin-Tok, Tugba, SEFEROĞLU, ZEYNEL, Doyuran, Bensu, Özen, Gülşah, Duyar, Halil   +5 more
openaire   +3 more sources