Results 11 to 20 of about 4,598 (120)

Substructure-activity relationship studies on antibody recognition for phenylurea compounds using competitive immunoassay and computational chemistry. [PDF]

Sci Rep, 2018
AbstractBased on the structural features of fluometuron, an immunizing hapten was synthesized and conjugated to bovine serum albumin as an immunogen to prepare a polyclonal antibody. However, the resultant antibody indicated cross-reactivity with 6 structurally similar phenylurea herbicides, with binding activities (expressed by IC50 values) ranging ...
Zhang F, Liu B, Liu G, Zhang Y, Wang J, Wang S.   +5 more
europepmc   +4 more sources

The Development of Selective Chemical Probes for Serine Arginine Protein Kinase 3. [PDF]

Chem Biol Drug Des
The development of the first reported chemical probes selective for SRPK3. 1‐(4‐cyanophenyl)‐3‐phenylurea was identified as an initial hit for SRPK3 through a kinase screen and further optimized to produce the top compound BP152 that has an SRPK3 IC50 of 2.1 μM, high selectivity over SRPK1 and SRPK2, and in vitro anti‐cancer activity.
Hanke D, McCutcheon C, Page BDG.
europepmc   +2 more sources

Synthesis of 2-Aryl(alkyl)benzimidazole Hydroxamic Acids as HDAC Inhibitors with Anti-Angiogenesis Properties. [PDF]

ChemMedChem
2‐Aryl(alkyl)benzimidazole hydroxamic acids (11‐16) are potent and selective HDAC6 inhibitors, with minimal activity against HDAC1/2, and also display anti‐angiogenic and anticancer activities. Compound 13 exhibited a GI50 of 3.9 μM against EPCs and inhibited the growth of HCT‐116, SK‐Hep‐1, and PC‐3 cells with GI50 values of 1.3, 4.2, and 7.5 μM ...
Liu YT, Lai CT, Wang SW, Liu SC, Hwang YL, Tsai YC, Lee CY, Lai YW, Yen JY, Wang PC, Lee HY.   +10 more
europepmc   +2 more sources

Evaluation of the Binding Properties of A New Phenylurea Appended Carbazole Compound to Pepsin/Trypsin by Computational and Multi-Spectral Analysis

Journal of Fluorescence, 2023
Abstract A novel carbazole compound, named 1-(9-ethyl-9H-carbazol-3-yl)-3-phenylurea (Cpu) was synthesized and its binding properties with protease enzymes (pepsin and trypsin) has been examined by steady-state fluorescence measurements, UV/vis absorption, infrared (FT-IR) and circular dicroism (CD) spectroscopies and also computational methods.
GÖKOĞLU, ELMAS, Taskin-Tok, Tugba, SEFEROĞLU, ZEYNEL, Doyuran, Bensu, Özen, Gülşah, Duyar, Halil   +5 more
openaire   +3 more sources

On the Thermal Dissociation of Organic Compounds. XII. The Effects of the Substituents on the Thermal Dissociation of Substituted Phenylureas [PDF]

Bulletin of the Chemical Society of Japan, 1957
Abstract Eleven new ureas of the type, 1,1-diethyl-3-arylureas and 1-pentyl-3-arylureas were synthesized. The rate constants and ρ values of thermal dissociation of these ureas in fatty acids were determined. In 1,1-diethyl-3-arylureas, the ρ value of the dissociation reaction at 95°C.
Shoichiro Ozaki, Tsutomu Nagoya
openaire   +1 more source

Decoding Urease Inhibition: A Comprehensive Review of Inhibitor Scaffolds. [PDF]

ChemMedChem
Representative functional groups known for urease inhibition are reviewed within diverse scaffolds using structure–activity analyses to identify features associated with high inhibitory activity. Urease is a metalloenzyme produced by a wide range of organisms and plays a critical role in nitrogen microbial metabolism by catalyzing the hydrolysis of ...
Martinho N, Aniceto N.
europepmc   +2 more sources

Synthesis and crystal structure of N-(3-benzylamino-2- cyano-3-methylthioacrylyl)-N'-(substituted phenyl)ureas

Bulletin of the Chemical Society of Ethiopia, 2013
Phenylurea groups were introduced into the frame of traditional cyanoacrylate and a series of N-(3-benzylamino-2-cyano-3-methylthioacrylyl)-N'-(substituted phenyl)ureas were synthesized. All compounds are new and their structures were confirmed by 1H NMR,
D.M. Wei, B.Y. Liu, M.L. Fan, S.H. Zhong, J.B. Liu   +4 more
doaj   +1 more source

Ditopic Receptors Based on Dihomooxacalix[4]arenes Bearing Phenylurea Moieties With Electron-Withdrawing Groups for Anions and Organic Ion Pairs

Frontiers in Chemistry, 2019
Two bidentate dihomooxacalix[4]arene receptors bearing phenylurea moieties substituted with electron-withdrawing groups at the lower rim via a butyl spacer (CF3-Phurea 5b and NO2 Phurea 5c) were obtained in the cone conformation in solution, as shown by ...
Alexandre S. Miranda, Alexandre S. Miranda, Defne Serbetci, Paula M. Marcos, Paula M. Marcos, José R. Ascenso, Mário N. Berberan-Santos, Neal Hickey, Silvano Geremia   +8 more
doaj   +1 more source

Ureidopyrazine Derivatives: Synthesis and Biological Evaluation as Anti-Infectives and Abiotic Elicitors

Molecules, 2017
Tuberculosis (TB) caused by Mycobacterium tuberculosis (Mtb) has become a frequently deadly infection due to increasing antimicrobial resistance. This serious issue has driven efforts worldwide to discover new drugs effective against Mtb.
Ghada Bouz, Martin Juhás, Pavlína Niklová, Ondřej Janďourek, Pavla Paterová, Jiří Janoušek, Lenka Tůmová, Zuzana Kovalíková, Petr Kastner, Martin Doležal, Jan Zitko   +10 more
doaj   +1 more source

New aminoporphyrins bearing urea derivative substituents: synthesis, characterization, antibacterial and antifungal activity

Brazilian Archives of Biology and Technology, 2015
This work studied the synthesis of 5,10,15-tris(4-aminophenyl)-20-(N,N-dialkyl/diaryl-N-phenylurea) porphyrins (P1-P4 with alkyl or aryl groups of Ph, iPr, Et and Me, respectively) and also the preparation of their manganese (III) and cobalt (II ...
Gholamreza Karimipour, Saeed Kowkabi, Asghar Naghiha   +2 more
doaj   +1 more source