Results 41 to 50 of about 5,279,436 (193)

1-Benzhydryl-3-phenylurea and 1-Benzhydryl-3-phenylthiourea Derivatives:  New Templates among the CB₁ Cannabinoid Receptor Inverse Agonists

, 2016
New 1-benzhydryl-3-phenylurea derivatives and their 1-benzhydryl-3-phenylthiourea isosteres were synthesized and evaluated for their human CB1 and CB2 cannabinoid receptor affinity. These compounds proved to be selective CB1 cannabinoid receptor ligands,
Jacques H. Poupaert (2069590), Johan Wouters (49810), Wolfgang Poppitz (2651602), Gerhard K. E. Scriba (2113489), Giulio G. Muccioli (199353), Didier M. Lambert (199355)   +5 more
core   +1 more source

Novel quinazolines bearing 1,3,4-thiadiazole-aryl urea derivative as anticancer agents: design, synthesis, molecular docking, DFT and bioactivity evaluations

BMC Chemistry
A novel series of 1-(5-((6-nitroquinazoline-4-yl)thio)-1,3,4-thiadiazol-2-yl)-3-phenylurea derivatives 8 were designed and synthesized to evaluate their cytotoxic potencies.
Sara Masoudinia, Marjaneh Samadizadeh, Maliheh Safavi, Hamid Reza Bijanzadeh, Alireza Foroumadi   +4 more
doaj   +1 more source

Identification of New CD36 Antagonists by Structure‐Based Virtual Screening

Chemical Biology &Drug Design, Volume 106, Issue 5, November 2025.
Virtual screening identified drug‐like molecules as potential CD36 antagonists; some of them inhibited CD36 function in relevant cellular models. These antagonists could drive the development of CD36‐targeted therapies. ABSTRACT CD36 is a transmembrane glycoprotein that facilitates the uptake of fatty acids and oxidized low‐density lipoproteins.
Sandra L. Guerrero‐Rodríguez, Luis Córdova‐Bahena, Fabiola Cortés‐Mendoza, Angel J. Ruiz‐Moreno, Cecilia Mata‐Cruz, Mireya Velázquez‐Paniagua, Nohemí Salinas‐Jazmín, Martín González‐Andrade, Marco A. Velasco‐Velázquez   +8 more
wiley   +1 more source

Impact of CPPU and combined CPPU-thidiazuron treatments on fruit quality and volatile compounds in 'Jinling Xiangxin' grapes

Technology in Horticulture
(2-Chloro-4-pyridyl)-N′-phenylurea (CPPU) is a widely used plant growth regulator (PGR) in table grape production to promote seedlessness and increase berry size. However, the mechanisms by which PGRs influence aroma quality remain poorly understood.
Huan Zheng, Yixu Wang, Mengfan Ren, Jingyi Chen, Liyuan Huang, Wen Zhang, Haoran Li, Ke Du, Jianmin Tao   +8 more
doaj   +1 more source

[Mathematical prediction of indicators of toxicity and hygienic standardization of phenylurea compounds].

Gigiena i sanitariia, 1990
The relation between physical and chemical constants and toxicometric indicators has been used as the basis of mathematical simulation both of separate indices of toxicity and preliminary safety exposure levels of the compounds of phenylurea series, thus it becomes possible to apply the derived mathematical links for rapid hygienic norm-setting of new ...
A I, Gurova, N A, Drozhzhina
openaire   +1 more source

FPR2 Agonism Attenuates Restenosis by Mitigating Neointimal Hyperplasia via ELOVL6

The FASEB Journal, Volume 39, Issue 17, 15 September 2025.
Restenosis after revascularization in lower extremity arterial disease remains a major unmet need. We demonstrate reduced formylpeptide receptor 2 (FPR2) expression in human restenotic arteries and demonstrate that FPR2 deficiency exacerbates neointimal hyperplasia.
Qian Zhang, Yuqin Zha, Xiaoting Wang, Peishen Zhao, Owen L. Woodman, Mi Zhou, Yuguo Chen, Xiaojun Zhou, Cheng Xue Qin   +8 more
wiley   +1 more source

Synthesis of New N,N′‐Diarylureas and Their Theoretical Study as Cannabinoid‐1 Receptor Inhibitors

ChemPlusChem, Volume 90, Issue 8, August 2025.
A series of new pyrazolo‐ and triazolo‐based N,N′‐diarylureas is synthesized following the triphosgene protocol in the last step. Density functional theory calculations and molecular docking provide strong evidence that all new compounds bind strongly to the cannabinoid‐1 (CB‐1) receptor, showing comparable results with the known allosteric CB‐1 ...
Eirini Tsemperlidou, Nikitas Georgiou, Demeter Tzeli, Nikolaos Karousis, George Varvounis   +4 more
wiley   +1 more source

Adsorption of phenylurea herbicides by tropical soils

, 2020
The distribution of pesticides in soils with consequences for their mobility, bioavailability and water contamination is mainly ruled by sorption processes. Such processes are seldom investigated in tropical soils.
Fischer, Klaus, Agbaogun, Babatunde
core   +1 more source

Synthesis of a Library of Bifunctional N‐Heterocyclic Carbene Ligand Precursors with Hydrogen Bond Donor Subunits

European Journal of Organic Chemistry, Volume 28, Issue 27, July 25, 2025.
A straightforward two‐step synthesis to bifunctional precursors of N‐heterocyclic carbenes (NHCs) is developed. Based on this, a library of imidazolium‐based NHCs, with a variety of hydrogen bond donor groups in the backbone is prepared. The utility of the bifunctional NHC ligands is demonstrated in transition metal catalysis with the resulting ...
Dimitrios‐Ioannis Tzaras, Maximilian Voigtländer, Birte M. Zimmermann, Tobias Rüffer, Johannes F. Teichert   +4 more
wiley   +1 more source

Catalytic effect of dissolved humic acids on the chemical degradation of phenylurea herbicides

, 2008
BACKGROUND: Although biodegradation seems to be the main cause of herbicide degradation, abiotic degradation can also be important for chemicals such as phenylureas, which are subject to catalysed soil reactions.
Capasso S, IOVINO, Pasquale, SALVESTRINI, Stefano   +2 more
core   +1 more source