Results 31 to 40 of about 5,279,436 (193)

Toxicity of representative organophosphate, organochlorine, phenylurea, dinitroaniline, carbamate, and viologen pesticides to the growth and survival of H. vulgaris, L. minor, and C. elegans

Environmental science and pollution research international
Pesticides are commonly found in the environment and pose a risk to target and non-target species; therefore, employing a set of bioassays to rapidly assess the toxicity of these chemicals to diverse species is crucial.
Kelly J. Rivenbark, H. Nikkhah, Meichen Wang, Burcu Beykal, Timothy D. Phillips   +4 more
semanticscholar   +1 more source

Synthesis of 2‐Aryl(alkyl)benzimidazole Hydroxamic Acids as HDAC Inhibitors with Anti‐Angiogenesis Properties

ChemMedChem, Volume 21, Issue 8, 28 April 2026.
2‐Aryl(alkyl)benzimidazole hydroxamic acids (11‐16) are potent and selective HDAC6 inhibitors, with minimal activity against HDAC1/2, and also display anti‐angiogenic and anticancer activities. Compound 13 exhibited a GI50 of 3.9 μM against EPCs and inhibited the growth of HCT‐116, SK‐Hep‐1, and PC‐3 cells with GI50 values of 1.3, 4.2, and 7.5 μM ...
Yi‐Ting Liu, Cheng‐Ta Lai, Shih‐Wei Wang, Shan‐Chi Liu, Yi‐Lin Hwang, Yi‐Chen Tsai, Chi‐Yeh Lee, Yu‐Wei Lai, Juei‐Yu Yen, Po‐Chuan Wang, Hsueh‐Yun Lee   +10 more
wiley   +1 more source

Design, Synthesis, Molecular Docking, and Anticancer Activity of Chalcone Derivatives as VEGFR-2 Inhibitors

Molecules
A series of 4-phenylurea chalcones (2a–2s) as VEGFR-2 inhibitors has been designed, synthesized, and evaluated for in vitro cytotoxic activity against K562, SiHa, and B16 cancer cells.
Mingjun Yu, Xin Zhang, Hui Zhu, Xiaoqian Zhang   +3 more
doaj   +1 more source

Decoding Urease Inhibition: A Comprehensive Review of Inhibitor Scaffolds

ChemMedChem, Volume 21, Issue 2, January 2026.
Representative functional groups known for urease inhibition are reviewed within diverse scaffolds using structure–activity analyses to identify features associated with high inhibitory activity. Urease is a metalloenzyme produced by a wide range of organisms and plays a critical role in nitrogen microbial metabolism by catalyzing the hydrolysis of ...
Nuno Martinho, Natália Aniceto
wiley   +1 more source

Exogenous Cytokinin 4PU-30 Modulates the Response of Wheat and Einkorn Seedlings to Ultraviolet B Radiation

Plants
Abiotic stress is responsible for a significant reduction in crop plant productivity worldwide. Ultraviolet (UV) radiation is a natural component of sunlight and a permanent environmental stimulus.
Elisaveta Kirova, Irina Moskova, Vasilissa Manova, Yana Koycheva, Zoia Tsekova, Denitsa Borisova, Hristo Nikolov, Ventzeslav Dimitrov, Iskren Sergiev, Konstantina Kocheva   +9 more
doaj   +1 more source

The optimization of crop response to climatic stress through modulation of plant stress response mechanisms. Opportunities for biostimulants and plant hormones to meet climate challenges.

New Phytologist, Volume 249, Issue 1, Page 130-151, January 2026.
Summary This review discusses the use of agronomic management practices to enhance crop stress resilience to climate stress through the modulation of natural plant growth regulatory pathways. The use of biostimulants or plant hormones to improve crop resilience is subject to strict regulatory oversight if changes in the regulation of plant growth are ...
Jing Li, Giulia Forghieri, Danny Geelen, Patrick du Jardin, Patrick H. Brown   +4 more
wiley   +1 more source

Clean up of phenylurea herbicides in plant sample extracts using molecularly imprinted polymers

, 2005
Two different molecularly imprinted polymers (MIPs) were prepared by precipitation polymerization using linuron or isoproturon (phenylurea herbicides) as templates and trifluormethacrylic acid as functional monomer. These materials were used as selective
Martín Esteban, A., Casillas, José Luis, Casillas, J. L., Martín Esteban, Antonio, Tamayo, Fernando G., Tamayo, F. G.   +5 more
core   +1 more source

Substituted 1-(benzo[d]thiazol-2-yl)-3-phenylurea derivatives as anti-invasion agents.

Bioorganic & Medicinal Chemistry Letters
Developing small molecule drugs to treat metastatic cancer remains challenging and relies on the identification of novel druggable targets within the multistep metastatic cascade.
Reilly K. Gwinn, Padmanabhan Mannangatti, Shahid Maqbool Mir, Shikha Kumari, M. K. Le, Swadesh K. Das, Paul B. Fisher, Webster L. Santos   +7 more
semanticscholar   +1 more source

Vasoactivity of Rac GTPase, Cytohesin and Kinase Inhibitors in Renal Interlobar and Coronary Arteries Reveals Shared and Distinct Patterns of Inhibitory Effects in Vascular and Prostate Smooth Muscle Contraction

Pharmacology Research &Perspectives, Volume 13, Issue 6, December 2025.
ABSTRACT Inhibition of vasocontraction accounts for side effects in treating voiding symptoms in benign prostatic hyperplasia (BPH). We examined the vasoactivity of compounds previously showing inhibition of prostate smooth muscle contraction. Contractions of porcine renal interlobar and coronary arteries were induced by agonists or electric field ...
Guangyang Liu, Sheng Hu, Alexander Tamalunas, Oluwafemi Kale, Yajie Xu, Christian G. Stief, Martin Hennenberg   +6 more
wiley   +1 more source

Proteome Analysis of the Specific Proteins From Japanese Birch Callus Infected With a Canker‐Rot Fungus Inonotus Obliquus Strain IO‐U1 (NBRC 113406)

Forest Pathology, Volume 55, Issue 6, December 2025.
ABSTRACT The specific proteins from Japanese birch (Betula platyphylla var. japonica plantlet No. 8) callus infected with a canker‐rot fungus Inonotus obliquus strain IO‐U1 (NBRC 113406) at the early infection stage were identified using proteome analysis. The intact, wounded, and infected calli were prepared, and the protein samples obtained at 2 days
Retno Agnestisia, Rei Chino, Ikumi Nezu, Futoshi Ishiguri, Takayuki Tohge, Shinso Yokota   +5 more
wiley   +1 more source