Results 51 to 60 of about 4,825 (166)

Novel quinazolines bearing 1,3,4-thiadiazole-aryl urea derivative as anticancer agents: design, synthesis, molecular docking, DFT and bioactivity evaluations

BMC Chemistry
A novel series of 1-(5-((6-nitroquinazoline-4-yl)thio)-1,3,4-thiadiazol-2-yl)-3-phenylurea derivatives 8 were designed and synthesized to evaluate their cytotoxic potencies.
Sara Masoudinia, Marjaneh Samadizadeh, Maliheh Safavi, Hamid Reza Bijanzadeh, Alireza Foroumadi   +4 more
doaj   +1 more source

Identification of New CD36 Antagonists by Structure‐Based Virtual Screening

Chemical Biology &Drug Design, Volume 106, Issue 5, November 2025.
Virtual screening identified drug‐like molecules as potential CD36 antagonists; some of them inhibited CD36 function in relevant cellular models. These antagonists could drive the development of CD36‐targeted therapies. ABSTRACT CD36 is a transmembrane glycoprotein that facilitates the uptake of fatty acids and oxidized low‐density lipoproteins.
Sandra L. Guerrero‐Rodríguez, Luis Córdova‐Bahena, Fabiola Cortés‐Mendoza, Angel J. Ruiz‐Moreno, Cecilia Mata‐Cruz, Mireya Velázquez‐Paniagua, Nohemí Salinas‐Jazmín, Martín González‐Andrade, Marco A. Velasco‐Velázquez   +8 more
wiley   +1 more source

Design and synthesis of BPR1K653 derivatives targeting the back pocket of Aurora kinases for selective isoform inhibition [PDF]

, 2018
[[abstract]]Twenty five novel chemical analogs of the previously reported Aurora kinase inhibitor BPR1K653 (1-(4-(2-((5-chloro-6-phenylfuro[2,3-d]pyrimidin-4-yl)amino)ethyl)phenyl)-3-(2-((dimethylamino)methyl)phenyl)urea) have been designed, synthesized,
Ke, YY;Chang, CP;Lin, WH;Tsai, CH;Chiu, IC;Wang, WP;Wang, PC;Chen, PY;Lin, WH;Chang, CF;Kuo, PC;Song, JS;Shih, C;Hsieh, HP;Chi, YH
core   +1 more source

Impact of CPPU and combined CPPU-thidiazuron treatments on fruit quality and volatile compounds in 'Jinling Xiangxin' grapes

Technology in Horticulture
(2-Chloro-4-pyridyl)-N′-phenylurea (CPPU) is a widely used plant growth regulator (PGR) in table grape production to promote seedlessness and increase berry size. However, the mechanisms by which PGRs influence aroma quality remain poorly understood.
Huan Zheng, Yixu Wang, Mengfan Ren, Jingyi Chen, Liyuan Huang, Wen Zhang, Haoran Li, Ke Du, Jianmin Tao   +8 more
doaj   +1 more source

[Mathematical prediction of indicators of toxicity and hygienic standardization of phenylurea compounds].

Gigiena i sanitariia, 1990
The relation between physical and chemical constants and toxicometric indicators has been used as the basis of mathematical simulation both of separate indices of toxicity and preliminary safety exposure levels of the compounds of phenylurea series, thus it becomes possible to apply the derived mathematical links for rapid hygienic norm-setting of new ...
A I, Gurova, N A, Drozhzhina
openaire   +1 more source

FPR2 Agonism Attenuates Restenosis by Mitigating Neointimal Hyperplasia via ELOVL6

The FASEB Journal, Volume 39, Issue 17, 15 September 2025.
Restenosis after revascularization in lower extremity arterial disease remains a major unmet need. We demonstrate reduced formylpeptide receptor 2 (FPR2) expression in human restenotic arteries and demonstrate that FPR2 deficiency exacerbates neointimal hyperplasia.
Qian Zhang, Yuqin Zha, Xiaoting Wang, Peishen Zhao, Owen L. Woodman, Mi Zhou, Yuguo Chen, Xiaojun Zhou, Cheng Xue Qin   +8 more
wiley   +1 more source

Microwave-induced synthesis of fluorine containing 1, 5-disubstituted hydantoins and thiohydantoins and their antibacterial activity [PDF]

, 2005
1084-1087Ten new fluorine containing 1, 5-disubstituted hydantoins/thiohydantoi-  ns 3 have been synthesized by a microwave-assisted solvent-free condensation of arylglyoxals1 and phenylurea/thiourea 2 using acidic alumina as a solid support.
Desai, K R, Patel, V M, K. R. Desai, V. M. Patel   +3 more
core   +1 more source

Synthesis of New N,N′‐Diarylureas and Their Theoretical Study as Cannabinoid‐1 Receptor Inhibitors

ChemPlusChem, Volume 90, Issue 8, August 2025.
A series of new pyrazolo‐ and triazolo‐based N,N′‐diarylureas is synthesized following the triphosgene protocol in the last step. Density functional theory calculations and molecular docking provide strong evidence that all new compounds bind strongly to the cannabinoid‐1 (CB‐1) receptor, showing comparable results with the known allosteric CB‐1 ...
Eirini Tsemperlidou, Nikitas Georgiou, Demeter Tzeli, Nikolaos Karousis, George Varvounis   +4 more
wiley   +1 more source

A Systematic Review of Synthetic and Anticancer and Antimicrobial Activity of Quinazoline/Quinazolin‐4‐one Analogues

ChemistryOpen, Volume 14, Issue 7, July 2025.
Quinazoline represents an important class of heterocycles with diverse medicinal and pharmacological significance. This review systematically examines scholarly efforts toward understanding different synthetic pathways emphasizing the role of metal and non‐metal catalysts including some miscellaneous reagents employed in the synthesis of quinazoline ...
Neha Manhas, Gobind Kumar, Sanjeev Dhawan, Talent Makhanya, Parvesh Singh   +4 more
wiley   +1 more source

Bifunctional Chiral ImPy‐Carbene Ligands. H‐Bonding Controlled Reactivity and Enantioselectivity in Au(I)‐Catalysis

Chemistry – A European Journal, Volume 31, Issue 35, June 23, 2025.
A new class of catalytically highly efficient bifunctional imidazopyridine (ImPy)‐based gold(I) complexes was synthesized. The ligands are based on tetrahedral C‐stereogenic centers derived from straightforward chiral pool synthesis. Unprecedented cycloisomerization products of 1,6‐enynols were observed in excellent enantioselectivity up to 99:1 er ...
Lukas Enders, Riccardo Mobili, Louis Fensterbank, Juho Helaja, Virginie Mouriès‐Mansuy   +4 more
wiley   +1 more source