Results 111 to 120 of about 2,223,665 (257)

The Endothelial CXCR Family in Vascular Health and Disease

iNew Medicine, EarlyView.
ABSTRACT Endothelial cells (ECs) form the dynamic interface between blood and tissue, serving as key regulators of vascular homeostasis, inflammation, and repair. Among the molecular systems governing endothelial behavior, the C‐X‐C motif chemokine receptor (CXCR) family—originally characterized in immunology for its roles in leukocyte trafficking and ...
Zhiming Wu, Yandi Wu, Suowen Xu, Yu Huang, Li Wang   +4 more
wiley   +1 more source

ATP Citrate Lyase in Metabolic Disease: Mechanistic Insights and Clinical Potential

iNew Medicine, EarlyView.
ATP citrate lyase (ACLY) is a central metabolic hub that diverts mitochondrial citrate to fuel de novo lipogenesis, cholesterol biosynthesis, and protein acetylation. Given its robust correlation with pathological changes in multiple human diseases, ACLY inhibitors featuring distinct pharmacological strengths have been developed for therapeutic ...
Wenbiao Wang, Xinyan Li, Honglu Shi, Gaolei Song, Zhifu Xie, Jingya Li   +5 more
wiley   +1 more source

Activation of MET promotes resistance to sorafenib in hepatocellular carcinoma cells via the AKT/ERK1/2-EGR1 pathway

Artificial Cells, Nanomedicine, and Biotechnology, 2019
Sorafenib is an oral multikinase inhibitor that has become an established therapeutic approach in advanced hepatocellular carcinoma (HCC). However, the benefit of sorafenib in clinical therapy is often affected by drug resistance.
Qing-Feng Xiang, Mei-Xiao Zhan, Yong Li, Hui Liang, Cong Hu, Yao-Ming Huang, Jing Xiao, Xu He, Yong-Jie Xin, Min-Shan Chen, Li-Gong Lu   +10 more
doaj   +1 more source

Inhibition of SIRT7 overcomes sorafenib acquired resistance by suppressing ERK1/2 phosphorylation via the DDX3X-mediated NLRP3 inflammasome in hepatocellular carcinoma

Aims: Sirtuin 7 (SIRT7) plays an important role in tumor development, and has been characterized as a potent regulator of cellular stress. However, the effect of SIRT7 on sorafenib acquired resistance remains unclear and a possible anti-tumor mechanism ...
Verbeek, Jef, Xu, Pan, Auwerx, Johan, Lee, Chang-Woo, Kim, Yun Hak, Kang, Baeki E., Bae, Sung-Jin, Jung, Hee Jung, Lee, Junguee, Ha, Ki-Tae, Kim, Doyoun, Schoonjans, Kristina, Kim, Kyun-Hwan, Kim, Yuna, Kim, Kwang Rok, Gariani, Karim, Shong, Minho, Gariani, Joanna, Jung, Kwan-Young, Jo, Yunju, Yi, Hyon-Seung, Ryu, Dongryeol, Nam, Seungyoon, Pandit, Navin, Kwon, Jeongho   +24 more
core   +1 more source

Sorafenib overcomes irinotecan resistance in colorectal cancer by inhibiting the ABCG2 drug-efflux pump.: Sorafenib inhibits ABCG2 and overcome irinotecan resistance.

, 2013
International audienceDespite recent advances in the treatment of colorectal cancer (CRC), tumor resistance is a frequent cause of chemotherapy failure.
Leconet, Wilhem, Jarlier, Marta, Evrard, Alexandre, Martineau, Pierre, Mazard, Thibault, Vezzio-Vie, Nadia, Torro, Adeline, del Rio, Maguy, Gongora, Celine, Causse, Annick, Ychou, Marc, Assenat, Eric, Simony, Joelle, Robert, Bruno   +13 more
core   +1 more source

Ultra‐High Frequency Ultrasound Imaging and Quantification of Microvascular Flow in Xenograft Renal Cell Carcinoma in an Avian Chorioallantoic Membrane Model

Journal of Ultrasound in Medicine, EarlyView.
Patient‐derived xenograft (PDX) tumor models initiated in avian chorioallantoic membranes (CAM) are under investigation to evaluate the effectiveness of therapeutic options with the objective of personalizing treatments. CAM PDXs paired with ultra‐high frequency ultrasound (UHFUS) imaging could potentially constitute prospective high throughput assays ...
Sara Mar, Emmanuel Chérin, Justin Xu, David E. Goertz, Hon S. Leong, Christine E.M. Demore   +5 more
wiley   +1 more source

Organoid Coculture Models for Cancer Research and Immunotherapy

Med Research, EarlyView.
This review summarizes organoid coculture platforms, including submerged Matrigel culture, air–liquid interface, microfluidic/organoid‐on‐a‐chip, and 3D bioprinting, for reconstructing the tumor microenvironment to study tumor–stroma/immune crosstalk, evaluate immunotherapies, and enable drug screening.
Zhuo Yang, Huihui Yang, Guangxin Li, Guobang Liu, Zhulan Chen, Wenzhi Tian, Meiyang Huang, Xiaoling Liu, Yongsheng Zhao, Dong Chen   +9 more
wiley   +1 more source

The FGF/FGFR System in the Biology and Therapeutic Landscape of Pediatric CNS Tumors

Medicinal Research Reviews, EarlyView.
ABSTRACT Central nervous system (CNS) tumors are the most common solid malignancies in children, comprising a highly heterogeneous group of neoplasms defined by distinct molecular alterations and clinical behaviors. Advances in molecular genetics have underscored the relevance of specific signaling pathways in driving pediatric tumorigenesis, among ...
Serena Filiberti, Camilla Tavani, Elena Somenza, Nicolas Tassone, Antonio d'Amati, Marta Turati, Roberto Ronca   +6 more
wiley   +1 more source

Nek2 augments sorafenib resistance by regulating the ubiquitination and localization of β-catenin in hepatocellular carcinoma

Journal of Experimental & Clinical Cancer Research, 2019
Background Sorafenib is the first-line treatment for advanced-stage hepatocellular carcinoma (HCC). Several studies have shown that the up-regulation of β-catenin plays a role in sorafenib resistance in HCC; however, the mechanism associated with this ...
Ling Deng, Jingyuan Sun, Xiaohui Chen, Li Liu, Dehua Wu   +4 more
doaj   +1 more source

Resistance of Renal Cell Carcinoma to Sorafenib Is Mediated by Potentially Reversible Gene Expression [PDF]

, 2011
Purpose: Resistance to antiangiogenic therapy is an important clinical problem. We examined whether resistance occurs at least in part via reversible, physiologic changes in the tumor, or results solely from stable genetic changes in resistant tumor ...
Zhang Liang, Atkins, Michael B., Rupal S Bhatt, S. Nahum Goldberg, Wang, Xiaoen, Bhasin, Manoj, Michael P. Collins, Alsop, David, Michael B Atkins, David C. Alsop, Signoretti Sabina, Mier James W., Goldberg, S., Panka, David, Panka David, Sabina Signoretti, Xiaoen Wang, Putheti Prabhakar, Libermann Towia, Liang Zhang, James W Mier, David Panka, Schor-Bardach, Rachel, Rachel Schor-Bardach, Zhang, Liang, Michael P Collins, Goldberg S. Nahum, Libermann, Towia, Signoretti, Sabina, Bhasin Manoj, Bhatt Rupal S., James W. Mier, Schor-Bardach Rachel, David C Alsop, Atkins Michael B., Putheti, P, S Nahum Goldberg, Collins, Michael P., Wang Xiaoen, Bhatt, Rupal, Manoj Bhasin, Prabhakar Putheti, Alsop David C., Collins Michael P., Michael B. Atkins, Rupal S. Bhatt, Mier, James, Towia Libermann   +47 more
core   +2 more sources