Results 71 to 80 of about 58,073 (253)

Impact of Stabilizing Osmolytes on the Conformational Dynamics of Human and Rat Islet Amyloid Polypeptides

Proteins: Structure, Function, and Bioinformatics, EarlyView.
ABSTRACT The aggregation of human islet amyloid polypeptide (hIAPP) into cytotoxic oligomers and amyloid fibrils is a hallmark of type 2 diabetes mellitus (T2DM), leading to pancreatic β‐cell dysfunction. In contrast, rat IAPP (rIAPP) is largely non‐amyloidogenic. Osmolytes such as glucose, glycerol, and sorbitol are known to stabilize globular protein
Kiara A. Kidman, Claudio Pedrick, Cara A. Kreck, Ricardo L. Mancera   +3 more
wiley   +1 more source

Temporal dynamics of co‐inoculation of Leptosphaeria maculans and Leptosphaeria biglobosa determine interspecific competition and disease development on oilseed rape

Pest Management Science, EarlyView.
This study provides evidence that the timing of co‐inoculation of Leptosphaeria maculans and Leptosphaeria biglobosa determine the outcome of interspecific competition and disease development on their host oilseed rape. Abstract BACKGROUND Phoma stem canker is one of the most economically damaging diseases of oilseed rape, caused by co‐existing fungal ...
Evren Bingol, Chinthani S. Karandeni Dewage, Aiming Qi, Faye Ritchie, Bruce DL Fitt, Yong‐Ju Huang   +5 more
wiley   +1 more source

Identification of sorbitol esterification of glutamic acid by LC-MS/MS in a monoclonal antibody stability assessment.

PLoS ONE
The stability of monoclonal antibodies (mAbs) is vital for their therapeutic success. Sorbitol, a common mAb stabilizer used to prevent aggregation, was evaluated for any potential adverse effects on the chemical stability of mAb X.
Bin Yu, Shannon Williams, Zhengdong Yang, Glen Young   +3 more
doaj   +1 more source

Structure–Property Relationships in Gelatine‐Based Systems Reinforced With Cotton Cellulose Nanocrystals: Toward Bio‐Based Coating Applications

Packaging Technology and Science, EarlyView.
Structure–property relationships in gelatine‐based systems reinforced with cotton cellulose nanocrystals revealed enhanced mechanical, optical and barrier properties for sustainable coating applications. ABSTRACT This study investigates structure–property relationships in gelatine‐based systems reinforced with cotton cellulose nanocrystals (CNCCs, 0 ...
Luan dos Santos Bispo de Souza, Indira Sardinha Caló Esteves, Isabel Cristina Rigoli   +2 more
wiley   +1 more source

Development of a Measurement System Using Infrared Spectroscopy-Attenuated Total Reflectance, Principal Component Analysis and Artificial Intelligence for the Safe Quantification of the Nucleating Agent Sorbitol in Food Packaging

Foods
Sorbitol derivatives and other additives are commonly used in various products, such as packaging or food packaging, to improve their mechanical, physical, and optical properties.
Joaquín Hernández-Fernández, Jose Martinez-Trespalacios, Edgar Marquez   +2 more
doaj   +1 more source

Exploring the Fragmentation of Sodiated Species Involving Covalent‐Bond Cleavages for Metabolite Characterization

Rapid Communications in Mass Spectrometry, EarlyView.
ABSTRACT Rationale Electrospray (ESI), the most popular desorption/ionization technique used in mass spectrometry‐based metabolomics, generates both protonated and deprotonated molecules, as well as adduct ions, sodium being the most frequent monoatomic cation entering their composition.
Annelaure Damont, Ekaterina Darii, Chenqin Cao, Anaïs Legrand, Alain Perret, Sylvain Dechaumet, Amina S. Woods, Christophe Junot, Jean‐Claude Tabet, François Fenaille   +9 more
wiley   +1 more source

Comparative Analysis of Stress Adaptation in the Yeast Microbiome of Cactus

Yeast, EarlyView.
Yeasts and related fungi isolated from cacti or nearby non‐cactus plants were characterized phenotypically and genomically, revealing differences that hint at modes of adaptation to the cactus host. ABSTRACT Together with other fungi, yeasts make up a significant component of the plant microbiome. As the planet warms, cacti expand their range.
Alya N. Hussain, Kevin T. Fotso, Michael A. McMurray   +2 more
wiley   +1 more source

Impact of Sorting and Catch Media on Porcine Sperm Motility, Capacitation, and Viability

Andrology, EarlyView.
ABSTRACT Background Fluorescence‐activated cell sorting (FACS) has emerged as a powerful tool for selecting spermatozoa of a desired population of fluorescent biomarkers, offering potential applications in reproductive biology and agriculture. However, concerns remain regarding sorting‐induced physiological alterations that could compromise spermatozoa
Tyler Weide, Juan Steibel, Karl Kerns
wiley   +1 more source

Brain viral reservoir seeding and neurological metabolic dysregulation in early‐life immunodeficiency virus infection

Brain Pathology, EarlyView.
Brain viral reservoirs were undetectable in neonatal SIV during the first 3 days post infection; antiretroviral therapy (ART) at 3 dpi prevented brain reservoir seeding and normalized metabolic function, highlighting the necessity of very early treatment to protect the developing CNS.
Li Ma, Robert Blair, Yao‐Zhong Liu, Xiaolei Wang, Eunice Vincent, Christopher Yu, Lara A. Doyle‐Meyers, Cissy Zhang, Ahmad Saied, Anne Le, Ronald S. Veazey, Qigui Yu, Huanbin Xu   +12 more
wiley   +1 more source

Retronasal Olfactory Function After Olfactory Training: A Prospective Single‐Arm Study

Clinical Otolaryngology, EarlyView.
ABSTRACT Background Retronasal olfaction is essential for aroma perception. Its impairment in individuals with olfactory dysfunction (OD) negatively affects dietary behaviour and quality of life. Regular exposure to odours in a form of olfactory training (OT) is used to rehabilitate the sense of smell.
Michal Pieniak, Maher Abou Nasr, Selin Bayindir, Thomas Hummel   +3 more
wiley   +1 more source