Results 81 to 90 of about 7,954 (200)

The reporting and handling of missing data in genetic epidemiological studies of mental health in childhood and adolescence: A systematic review

JCPP Advances, EarlyView.
Abstract Background Genetic epidemiological analyses of child and adolescent mental health often use data from prospective longitudinal cohorts. Missingness due to selective attrition is therefore an important potential source of bias in such analyses.
Meseret M. Bazezew, Adrian Dahl Askelund, Kate Tilling, Alexandra Havdahl, Laurie J. Hannigan   +4 more
wiley   +1 more source

The role of rare copy number variants in early‐onset depression

JCPP Advances, EarlyView.
Abstract Background Depression is a highly heterogeneous condition. Depression with an onset in childhood and early adolescence has a worse clinical course, is more heritable, and shows a lower genetic correlation with other depression subtypes, than does later‐onset depression.
Charlotte A. Dennison, Ida Sønderby, Miguel Garcia‐Argibay, Victoria Powell, Amy Shakeshaft, Lucy Riglin, Elliott Rees, Michael O’Donovan, Henrik Larsson, Ole Andreassen, Alexandra Havdahl, Joanna Martin, Anita Thapar   +12 more
wiley   +1 more source

The Combined Effects of Variable Viscosity and Thermal Conductivity of An Unsteady Casson Fluid Flow Along a Vertical Porous Channel With Convective Cooling Walls, Using the Bivariate Spectral Local Linearization Method

Mathematical Methods in the Applied Sciences, EarlyView.
ABSTRACT This study examines the combined impact of different thermal conductivity and viscosity on unsteady non‐Newtonian Casson fluid flow of incompressible, electrical conductivity in a porous vertical channel with convective cooling walls, uniform magnetic field, and constant pressure gradient.
A. S. Adeyemo, Precious Sibanda, S. P. Goqo   +2 more
wiley   +1 more source

Unraveling Structure‐Dependent Performance of Cu–N–C Molecular Catalysts for Electrocatalytic CO2 Methanation

Small, EarlyView.
Copper phthalocyanine (CuPc) and copper tetraphenylporphyrin (CuPr) both contain Cu–N4 sites, yet CuPc shows superior CO2‐to‐CH4 selectivity. Further analysis suggests that the Pc‐macrocycle tunes the electronic structure of Cu center and induces charge transfer, possibly via its π‐conjugated Pc‐ring and bridge‐N environment.
Tengyi Liu, Xiaofan Hou, Songbo Ye, Kosuke Ishibashi, Yutaro Hirai, Yasutaka Matsuo, Shimpei Ono, Hao Li, Hiroshi Yabu   +8 more
wiley   +1 more source

Training and validation of an automated algorithm to differentiate no and minimal diabetic retinopathy from more severe stages in wide‐field images

Acta Ophthalmologica, EarlyView.
Abstract Purpose Diabetic retinopathy (DR) is a leading cause of blindness in the working‐age population. Screening is essential to identify and treat sight‐threatening stages prior to irreversible visual loss. This study aimed to train and validate an automated algorithm to identify no or minimal DR, potentially saving resources for specialist ...
Lars Morten Skollerud, Jakob Kristian Andersen, Sebastian Dinesen, Thiusius Rajeeth Savarimuthu, Jakob Grauslund   +4 more
wiley   +1 more source

Afamelanotide improves quality of life and light tolerance in Austrian erythropoietic protoporphyria patients

JDDG: Journal der Deutschen Dermatologischen Gesellschaft, EarlyView.
Summary Background Erythropoietic protoporphyria (EPP) is a rare genetic disorder characterized by severe phototoxic reactions that occur within minutes of light exposure. In clinical studies, afamelanotide has been shown to prolong pain‐free sun exposure, improve quality of life, and reduce the frequency and severity of phototoxic reactions ...
Magdalena Seidl‐Philipp, Hanna Schratter, Johanna Auer, Gerold Schwantzer, Maximilian Lammer, Philipp Hinteregger, Ines Vergeiner, Robert Gruber, Peter Wolf, Angelika Hofer   +9 more
wiley   +1 more source

PEG400 regulates Falcipain 2 activity through an allosteric mechanism

The FEBS Journal, EarlyView.
Falcipain‐2 can potentially be leveraged as a drug target due to its critical role as a haemoglobinase during the intra‐erythrocytic stage of Plasmodium falciparum. Here, we investigate the regulation of the proteolytic and haemoglobinase activity of falcipain‐2 in the presence of polyethylene glycol.
Bikram Nath, Subhoja Chakraborty, Sampa Biswas   +2 more
wiley   +1 more source

Unraveling the active site cover of coproheme decarboxylase from Listeria monocytogenes

The FEBS Journal, EarlyView.
During heme biosynthesis in Gram‐positive bacteria, coproheme decarboxylase (ChdC) catalyzes the conversion of four‐propionate substrate coproheme to the two propionate product heme b. Its active site is universally covered by a flexible linking loop. This study identifies an important histidine residue, which stabilizes the loop in a ChdC homolog.
Nikolaus Falb, Dominik Hörtnagel, Chris Oostenbrink, Paul G. Furtmüller, Stefan Hofbauer   +4 more
wiley   +1 more source

Student–teacher relationships as a mediator of children's education‐linked genetics: results from the Norwegian Mother, Father and Child Cohort Study

Journal of Child Psychology and Psychiatry, EarlyView.
Background Genetic differences are robustly associated with educational outcomes, but how they become linked is poorly understood. A plausible hypothesis, yet to be thoroughly empirically tested, is that the school environment mediates the association. Methods Using structural equation models, we tested whether the student–teacher relationship at age 5
Chloe Austerberry, Elizabeth C. Corfield, Alexandra Havdahl, Dinka Smajlagic, Ragnhild Eek Brandlistuen, Mari Vaage Wang, Laurel Fish, Marialivia Bernardi, Jessica van de Grint‐Stoop, Mona Bekkhus, Pasco Fearon   +10 more
wiley   +1 more source

(Ultra)high‐Pressure Metamorphism in Sedimentary Versus Basaltic Rocks: Insights From a Variscan Mélange in the South Carpathians

Journal of Metamorphic Geology, EarlyView.
ABSTRACT Reconstructing the pressure–temperature–time (P–T–t) evolution of (ultra)high‐pressure rocks is essential for constraining subduction and collisional dynamics. Subduction zones are often investigated using basic eclogites, whereas nonbasic high‐pressure rocks remain comparatively understudied, potentially hindering a comprehensive ...
Otavio S. G. Silva, Bruno V. Ribeiro, Gavril Săbău, Fabricio Caxito, Paulo A. de Paiva‐Silva, Pierre Lanari, George Luvizotto, Mahyra Tedeschi   +7 more
wiley   +1 more source