Results 81 to 90 of about 308,183 (264)

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Building sustainable operational research capacity in Pakistan: starting with tuberculosis and expanding to other public health problems

Global Health Action, 2019
Background: For many years, operational research capacity has been a challenge and has remained a low priority for the health sector in Pakistan. Building research capacity for developing a critical mass of researchers in Pakistan was done through ...
Razia Fatima, Aashifa Yaqoob, Ejaz Qadeer, Sven Gudmund Hinderaker, Einar Heldal, Rony Zachariah, Anthony D. Harries, Ajay M. V. Kumar   +7 more
doaj   +1 more source

Patience Sorting and Its Generalizations

, 2007
Ph.D.
openaire   +3 more sources

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Viral load testing coverage and suppression rate among children and adolescents on ART in Sierra Leone

Public Health Action
SETTING: Anti-retroviral treatment (ART) centres from eight districts of Sierra Leone. OBJECTIVES: Among children and adolescents (0–19 years) registered for ART after January 2023 and currently on care, to assess i) viral load (VL) testing coverage and ...
F. Kanu, F. Lansana, M. Mustapha, E.K. Tabor, P. Thekkur, I.F. Kamara, B.D. Fofanah, J.S. Kanu, N. Sesay, I.S. Turay, J.A. Koroma, W.K. Lahai, A.M. Falama, M.A. Sesay, S. Lakoh   +14 more
doaj   +1 more source

Catastrophic costs of tuberculosis care: a mixed methods study from Puducherry, India

Global Health Action, 2018
Background: The average expenditure incurred by patients in low- and middle-income countries towards diagnosis and treatment of TB ranges from $55 to $8198. This out-of-pocket expenditure leads to impoverishment of households.
Thirunavukkarasu Prasanna, Kathiresan Jeyashree, Palanivel Chinnakali, Yogesh Bahurupi, Kavita Vasudevan, Mrinalini Das   +5 more
doaj   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Fetal Brain Tumor Harboring a Unique ROCK1::BRAF Fusion

Pediatric Blood &Cancer, EarlyView.
Marllon Cindra Sant'Ana, Mariana Maschietto, Daniela Paz Leal, Ricardo de Santos de Oliveira, Mayara Ferreira Euzébio, Antonio Carlos dos Santos, Luciano Neder, Carlos Alberto Scrideli, Elvis Terci Valera   +8 more
wiley   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Neglected Tropical Diseases: responding to calls for action from the front lines in Ethiopia

Journal of Infection in Developing Countries, 2020
Ebba Abate, John C Reeder
doaj   +1 more source