Results 71 to 80 of about 2,796,496 (275)

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source

Smell-Aware Bug Classification

IEEE Access
Code smell indicates inadequacies in design and implementation choices. Code smells harm software maintainability including effects on components’ bug proneness and code quality has been demonstrated in previous studies.
Khyber, Sikandar Ali, Fazli Wahid, Samad Baseer, Ahmed Alkhayyat, Akram M. Al-Radaei   +5 more
doaj   +1 more source

SCORE: Source Code Optimization & REconstruction

IEEE Access, 2020
The main goal of obfuscation is to make software difficult to analyze. Although obfuscation is one useful method to protect programs, the ability to analyze malware is greatly reduced if used for malicious purposes.
Jae Hyuk Suk, Young Bi Lee, Dong Hoon Lee   +2 more
doaj   +1 more source

Source Code Verification for Embedded Systems using Prolog

, 2017
System relevant embedded software needs to be reliable and, therefore, well tested, especially for aerospace systems. A common technique to verify programs is the analysis of their abstract syntax tree (AST).
Flederer, Frank, Montenegro, Sergio, Ostermayer, Ludwig, Seipel, Dietmar   +3 more
core   +2 more sources

Characterizing the salivary RNA landscape to identify potential diagnostic, prognostic, and follow‐up biomarkers for breast cancer

Molecular Oncology, EarlyView.
This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan, Irina Primac, Emre Etlioglu, Laurens Debruyne, Ann Janssen, Magy Sallam, Kevin Tabury, Roel Quintens, Wiebren Tjalma, Mohammed Abderrafi Benotmane   +9 more
wiley   +1 more source

Inhibition of CDK9 enhances AML cell death induced by combined venetoclax and azacitidine

Molecular Oncology, EarlyView.
The CDK9 inhibitor AZD4573 downregulates c‐MYC and MCL‐1 to induce death of cytarabine (AraC)‐resistant AML cells. This enhances VEN + AZA‐induced cell death significantly more than any combination of two of the three drugs in AraC‐resistant AML cells.
Shuangshuang Wu, Jianlei Zhao, Aaban Asfar Azmi, Avanti Gupte, Jenna Thibodeau, Shuang Liu, Jinli Yang, Guan Wang, Holly Edwards, Lisa A. Polin, Juiwanna Kushner, Sijana H. Dzinic, Kathryn White, Julie Boerner, Maik Hüttemann, Jay Yang, Yue Wang, Jeffrey W. Taub, Yubin Ge   +18 more
wiley   +1 more source

Big Coding Data: Analysis, Insights, and Applications

IEEE Access
In recent years, there has been a notable surge in the generation of coding data on various platforms, including programming competitions and educational institutions.
Md. Mostafizer Rahman, Atsushi Shirafuji, Yutaka Watanobe   +2 more
doaj   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

A Language-Independent Library for Observing Source Code Plagiarism

Journal of Information Systems Engineering and Business Intelligence, 2019
Background: Most source code plagiarism detection tools are not modifiable. Consequently, when a modification is required to be applied, a new detection tool should be created along with it.
Ricardo Franclinton, Oscar Karnalim
doaj   +1 more source

The BELLFLOW system [PDF]

, 1970
The BELLFLOW flowcharting system was developed to meet certain Bell System standards of documentation. There are three modes of operation with the BELLFLOW system: source mode, comment mode, and mixed mode.
Pardee, S.
core   +1 more source