Results 71 to 80 of about 12,701,026 (316)

Clinical Course and Impact of Breaks in Therapy for Children With Relapsed/Refractory Solid Tumors

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Introduction Pediatric relapsed or refractory (R/R) solid tumors carry a dismal prognosis, and postrelapse patient experiences are not well described. We present postrelapse outcomes, including number of R/R events and subsequent therapy regimens.
Matthew T. McEvoy, Elizabeth L. Seashore, W. Susan Cheng, Shondra Clay, Jessica A. Casas, Jennifer H. Foster   +5 more
wiley   +1 more source

Employing Source Code Quality Analytics for Enriching Code Snippets Data

Data, 2023
The availability of code snippets in online repositories like GitHub has led to an uptick in code reuse, this way further supporting an open-source component-based development paradigm.
Thomas Karanikiotis, Themistoklis Diamantopoulos, Andreas Symeonidis   +2 more
doaj   +1 more source

Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10

FEBS Letters, EarlyView.
Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang, Satoshi Hashimoto, Sota Ito, Chisato Kikuguchi, Miho Hoshi, Kiyoshi Yamaguchi, Yoichi Furukawa, Toru Suzuki, Toshifumi Inada   +8 more
wiley   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

A Novel Method for Code Clone Detection Based on Minimally Random Kernel Convolutional Transform

IEEE Access
Effectively detecting code clones is essential for maintaining and evolving software systems. This paper introduces a novel approach that leverages minimally random kernel convolutional transform (MiniRocket) to represent source code for clone detection.
Mostefai Abdelkader
doaj   +1 more source

ORB-SLAM2: An Open-Source SLAM System for Monocular, Stereo, and RGB-D Cameras [PDF]

IEEE Transactions on robotics, 2016
We present ORB-SLAM2, a complete simultaneous localization and mapping (SLAM) system for monocular, stereo and RGB-D cameras, including map reuse, loop closing, and relocalization capabilities. The system works in real time on standard central processing
Raul Mur-Artal, J. D. Tardós
semanticscholar   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

Smell-Aware Bug Classification

IEEE Access
Code smell indicates inadequacies in design and implementation choices. Code smells harm software maintainability including effects on components’ bug proneness and code quality has been demonstrated in previous studies.
Khyber, Sikandar Ali, Fazli Wahid, Samad Baseer, Ahmed Alkhayyat, Akram M. Al-Radaei   +5 more
doaj   +1 more source

Optimal code design for lossless and near lossless source coding in multiple access networks [PDF]

, 2001
A multiple access source code (MASC) is a source code designed for the following network configuration: a pair of correlated information sequences {Xi}i=1∞ and {Yi }i=1∞ is drawn i.i.d.
Effros, Michelle, Zhao, Qian
core  

OpenMolcas: From source code to insight.

Journal of Chemical Theory and Computation, 2019
In this article we describe the OpenMolcas environment and invite the computational chemistry community to collaborate. The open-source project already includes a large number of new developments realized during the transition from the commercial MOLCAS ...
Ignacio Fernández Galván, M. Vacher, A. Alavi, C. Angeli, F. Aquilante, J. Autschbach, J. J. Bao, S. I. Bokarev, N. Bogdanov, Rebecca K. Carlson, L. Chibotaru, J. Creutzberg, N. Dattani, Mickaël G. Delcey, Sijia S. Dong, A. Dreuw, Leon Freitag, L. Frutos, L. Gagliardi, F. Gendron, A. Giussani, L. González, Gilbert Grell, Meiyuan Guo, Chad E. Hoyer, M. Johansson, Sebastian Keller, S. Knecht, G. Kovačević, E. Källman, G. Li Manni, M. Lundberg, Yingjin Ma, S. Mai, J. P. Malhado, P. Malmqvist, P. Marquetand, Stefanie A. Mewes, J. Norell, M. Olivucci, M. Oppel, Q. Phung, K. Pierloot, F. Plasser, M. Reiher, A. Sand, I. Schapiro, Prachi Sharma, Christopher J. Stein, L. Sørensen, D. Truhlar, Mihkel Ugandi, L. Ungur, A. Valentini, S. Vancoillie, V. Veryazov, O. Weser, T. Wesołowski, Per-Olof Widmark, S. Wouters, Alexander Zech, J. Zobel, R. Lindh   +62 more
semanticscholar   +1 more source