Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim +7 more
wiley +1 more source
Operative stewardship: reclaiming the role of surgical source control in dental antimicrobial stewardship. [PDF]
Joachim MV, Abramson A.
europepmc +1 more source
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic +10 more
wiley +1 more source
Atheroembolic Blue Toe Syndrome Progressing to Below-Knee Amputation Despite Attempted Source Control and Revascularization: A Case Report. [PDF]
Echavarria DD +4 more
europepmc +1 more source
Extracellular vesicle (EV) lipidomic profiling of plasma and ascites from patients with high‐grade serous ovarian cancer and of ovarian cancer cell lines reveals enrichment of triglycerides (TGs), diacylglycerols (DGs), phosphatidylcholine (PCs), sphingomyelins (SMs), reflecting tumor metabolic reprogramming.
Shikha Rani +9 more
wiley +1 more source
Cervical, Mediastinal, and Pericardial Disseminated Coccidioidomycosis: The Importance of Source Control. [PDF]
Grant L +4 more
europepmc +1 more source
Active control of a lumped acoustic source driven by various actuators
This paper studies a lumped model of an acoustic source with a relatively small thickness and high bending stiffness. Voice coil and piezoelectric actuators are used to drive moving components of the acoustic source.
Tajdari, F., Boer, A. de, Berkhoff, A.P.
core
High‐risk bladder cancer is typically treated with Bacillus Calmette‐Guérin (BCG), but 30–40% of patients relapse. No FDA‐ or CE‐approved biomarkers currently predict or prognosticate BCG failure. We systematically reviewed the literature and identified 72 eligible studies, revealing several promising biomarkers associated with BCG treatment response ...
Rui Ribeiro‐Pereira +7 more
wiley +1 more source
Planning and performing CT-guided interventions for source control in septic patients: a survey by the European Society of Emergency Radiology. [PDF]
Frisch A +11 more
europepmc +1 more source
Source control in emergency general surgery: WSES, GAIS, SIS-E, SIS-A guidelines. [PDF]
Coccolini F +63 more
europepmc +1 more source

