Results 51 to 60 of about 7,416,567 (229)

Structures of mycobacterial 3‐methylcrotonyl‐CoA carboxylase reveal carrier‐domain translocation between catalytic sites

open access: yesFEBS Letters, EarlyView.
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav   +2 more
wiley   +1 more source

Russian Language and Culture in Indirect Translation from English into Kazakh

open access: yesRUDN Journal of Language Studies, Semiotics and Semantics
Typically, translation process involves two languages and two lingua-cultural traditions. In Kazakhstan, the situation in the field of literary translation is really specific: it is an indisputable fact that in translation from Kazakh into English and ...
Leila Yu. Mirzoyeva   +3 more
doaj   +1 more source

Translations in the Years of Change of Power in Latvia (1939–1946)

open access: yesAkadēmiskā Dzīve, 2017
Latvia was occupied by the Soviet Union in 1940, by Nazi Germany in 1941 and again by the Soviet Union in 1944/1945. The translation scene during the fast-changing occupations of the 1940s is almost untouched area in Latvian translation history.
Andrejs Veisbergs
doaj   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

open access: yesMolecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller   +10 more
wiley   +1 more source

Suomen monitahoinen possessiivisuffiksi ja suomenoppija

open access: yesLähivõrdlusi, 2010
The article is concerned with the Finnish possessive suffix from the point of view of teaching and learning. First, this suffix and its present-day use are shortly studied. Then, it will be clarifi ed how this suffix is taught in the textbooks of Finnish
Kirsti Siitonen, Manami Mizuno
doaj   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

open access: yesMolecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang   +9 more
wiley   +1 more source

ML-Ask: Open Source Affect Analysis Software for Textual Input in Japanese

open access: yesJournal of Open Research Software, 2017
We present ML-Ask – the first Open Source Affect Analysis system for textual input in Japanese. ML-Ask analyses the contents of an input (e.g., a sentence) and annotates it with information regarding the contained general emotive expressions, specific ...
Michal Ptaszynski   +4 more
doaj   +1 more source

Predictive and prognostic biomarkers of Bacillus Calmette‐Guérin therapy failure in bladder cancer patients: A systematic review

open access: yesMolecular Oncology, EarlyView.
High‐risk bladder cancer is typically treated with Bacillus Calmette‐Guérin (BCG), but 30–40% of patients relapse. No FDA‐ or CE‐approved biomarkers currently predict or prognosticate BCG failure. We systematically reviewed the literature and identified 72 eligible studies, revealing several promising biomarkers associated with BCG treatment response ...
Rui Ribeiro‐Pereira   +7 more
wiley   +1 more source

Supertags as source language context in hierarchical phrase-based SMT [PDF]

open access: yes, 2010
Statistical machine translation (SMT) models have recently begun to include source context modeling, under the assumption that the proper lexical choice of the translation for an ambiguous word can be determined from the context in which it appears ...
Way, A.   +11 more
core   +2 more sources

Paclitaxel induces NM2‐dependent cellular contraction through GEF‐H1 dissociation from microtubules and RhoA/ROCK activation in cancer cells

open access: yesMolecular Oncology, EarlyView.
Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez   +5 more
wiley   +1 more source

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