Results 111 to 120 of about 10,524,393 (255)
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
FLOSS tools in computer forensics tertiary education
, 2008 In this paper we discuss the application of Free, Libre, and Open Source Software (FLOSS) tools in computer forensics education at tertiary level. We argue that FLOSS tools are more suitable than commercial tools, as they provide the opportunity for ...
Bem, Derek +2 more
core
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
Heat- and Ultrasound-Assisted Aqueous Extraction of Soluble Carbohydrates and Phenolics from Carob Kibbles of Variable Size and Source Material. [PDF]
Foods, 2020 Antoniou C +4 more
europepmc +1 more source
Molecular Oncology, EarlyView.Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller +10 more
wiley +1 more source
Target Optimisation Studies for the European Spallation Source [PDF]
, 2010 The European Spallation Source (ESS) is one of Europe’s biggest and most prestigious science projects. ESS will be the world’s most powerful next generation neutron spallation source for research with neutrons, providing a unique tool for studies of ...
Bungau, Adriana +2 more
core +1 more source
Molecular Oncology, EarlyView.Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur +11 more
wiley +1 more source
BuildingsHydraulic concrete suffers severe damage from high-velocity sand-bearing water flow. Traditional single-layer coating materials struggle to simultaneously satisfy the requirements of strong adhesion, high abrasion resistance, and long-term durability. In
Yu Chen +5 more
doaj +1 more source
Molecular Oncology, EarlyView.The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington +10 more
wiley +1 more source
"Let me share some of my knowledge with you. Please, I insist. From where this knoledge came, I cannot say for certain. All I can say is for certain. All I can say is that is is in my noggin'.
Source, Christine
core +1 more source