Results 131 to 140 of about 10,524,393 (255)

Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2

open access: yesMolecular Oncology, EarlyView.
We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee   +3 more
wiley   +1 more source

Experimenting with Small Open-Source Models for Practical Use

open access: yes
This lightning talk explores whether small, open-source language models can be used on less powerful servers for practical, real-world applications. The talk will share preliminary findings and discuss future directions, including exploring additional ...
Jiang, Lingling
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Gay and Lesbian community, support, and spirit Selected newsletters and periodicals from the holdings of the Gay, Lesbian, Bisexual Transgender Historical Society Selected periodicals from the GLBT Historical Society

open access: yes, 2005
Title from guide. Title on publisher's web site: Gay rights movement. Series 9. Gay and lesbian community, support, and spirit: Selected newspapers and periodicals from the Gay, Lesbian Bisexual and Transgender Historical Society.
Primary Source Microfilm
core  

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

open access: yesMolecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic   +10 more
wiley   +1 more source

Source de Teplitz (Bahème) la meilleure des eaux de tables.

open access: yes
SOURCE DE TEPLITZ (BAHÈME) LA MEILLEURE DES EAUX DE TABLES. Source de Teplitz (Bahème) la meilleure des eaux de tables. ( -
Source de Teplitz
core   +1 more source

Extracellular vesicle lipidomics liquid biopsy reveals systemic and tumor microenvironment metabolic reprogramming in ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Extracellular vesicle (EV) lipidomic profiling of plasma and ascites from patients with high‐grade serous ovarian cancer and of ovarian cancer cell lines reveals enrichment of triglycerides (TGs), diacylglycerols (DGs), phosphatidylcholine (PCs), sphingomyelins (SMs), reflecting tumor metabolic reprogramming.
Shikha Rani   +9 more
wiley   +1 more source

Cornell High Energy Synchrotron Source (CHESS)

open access: yes
Cornell High Energy Synchrotron Source (CHESS) "is a high-intensity high-energy X-ray source" for research in many scientific fields including materials science, physics, and chemistry.

core  

Predictive and prognostic biomarkers of Bacillus Calmette‐Guérin therapy failure in bladder cancer patients: A systematic review

open access: yesMolecular Oncology, EarlyView.
High‐risk bladder cancer is typically treated with Bacillus Calmette‐Guérin (BCG), but 30–40% of patients relapse. No FDA‐ or CE‐approved biomarkers currently predict or prognosticate BCG failure. We systematically reviewed the literature and identified 72 eligible studies, revealing several promising biomarkers associated with BCG treatment response ...
Rui Ribeiro‐Pereira   +7 more
wiley   +1 more source

Geochemical character and material source of sediments in the eastern Philippine Sea

open access: yes, 2008
Based upon analyses of grain-size, rare earth element (REE) compositions, elemental occurrence phases of REE, and U-series isotopic dating, the sediment characteristics and material sources of the study area were examined for the recently formed deep-sea
Li AnChun   +3 more
core  

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