Results 91 to 100 of about 5,011,192 (299)

Determination of focal mechanism solutions of the earthquakes with M≥4.0 occurred in the mainland of China during March to June 2024

open access: yes地震科学进展
In this paper,the regional full waveform inversion using the broadband waveforms recorded by China Seismic Network were conducted,and the focal mechanism solutions of the 59 earthquakes with M≥4.0 occurred in the mainland of China during March to June ...
Shanshan Liang   +4 more
doaj   +1 more source

Earthquake sources and seismic hazard in Southeastern Sicily

open access: yesAnnals of Geophysics, 2001
A study of some earthquakes (M > 5.3) affecting Southeastern Sicily was performed to define their seismic sources and to estimate seismic hazard in the region.
R. Rigano, M. S. Barbano
doaj   +1 more source

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

open access: yesMolecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta   +10 more
wiley   +1 more source

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

open access: yesMolecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon   +4 more
wiley   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

open access: yesMolecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley   +5 more
wiley   +1 more source

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns   +10 more
wiley   +1 more source

Characteristic Analysis of the MS6.0 Ma'erkang Earthquake Sequence on Jun. 10, 2022

open access: yesJournal of Risk Analysis and Crisis Response (JRACR)
On June 10, 2022, the MS6.0 Ma'erkang earthquake sequence occurred in the Bayan Har block. In this paper, the temporal and spatial distribution and attenuation characteristics of earthquake sequence is analyzed based on the regional structure, the ...
Yu-ping Qi   +7 more
doaj   +1 more source

Assessment of glacial-earthquake source parameters

open access: yesJournal of Glaciology, 2017
Glacial earthquakes are slow earthquakes of magnitude M~5 associated with major calving events at near-grounded marine-terminating glaciers. These globally detectable earthquakes provide information on the grounding state of outlet glaciers and the ...
STEPHEN A. VEITCH, MEREDITH NETTLES
doaj   +1 more source

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