Results 51 to 60 of about 5,011,192 (299)

Personalized Selumetinib Dosing in Pediatric Neurofibromatosis Type 1: Insights From a Pilot Therapeutic Drug Monitoring Study

open access: yesPediatric Blood &Cancer, EarlyView.
ABSTRACT Objective To evaluate selumetinib exposure using therapeutic drug monitoring (TDM) in pediatric patients with neurofibromatosis type 1 (NF1) and plexiform neurofibromas (PN), assess interpatient pharmacokinetic variability, and explore the relationship between drug exposure, clinical response, and adverse effects.
Janka Kovács   +8 more
wiley   +1 more source

Determination of focal mechanism solutions of the earthquakes with M≥4.0 occurred in the mainland of China during July to December 2024

open access: yes地震科学进展
In this paper,the regional full waveform inversion using the broadband waveforms recorded by China Seismic Network were conducted, and the focal mechanism solutions of the 38 earthquakes with M≥4.0 occurred in the mainland of China during July to ...
Shanshan Liang   +4 more
doaj   +1 more source

Chamber Surface Roughness and Electron Cloud for the Advanced Photon Source Superconducting Undulator

open access: yes, 2013
The electron cloud is a possible heat source in the superconducting undulator (SCU) designed for the Advanced Photon Source (APS), a 7-GeV electron synchrotron radiation source at Argonne National Laboratory.
Boon, Laura, Harkay, Katherine
core   +1 more source

Organoids in pediatric cancer research

open access: yesFEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Data analysis of continuous gravitational wave: All sky search and study of templates

open access: yes, 2002
We have studied the problem of all sky search in reference to continuous gravitational wave particularly for such sources whose wave-form are known in advance.
Apostolatos   +19 more
core   +1 more source

Image distortion in non perturbative gravitational lensing [PDF]

open access: yes, 2000
We introduce the idea of {\it shape parameters} to describe the shape of the pencil of rays connecting an observer with a source lying on his past lightcone.
A. O. Petters   +20 more
core   +2 more sources

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

Yano-Koonin-Podgoretskii Parametrisation of the Hanbury Brown-Twiss Correlator

open access: yes, 1996
The Yano-Koonin-Podgoretskii (YKP) parametrisation of Hanbury Brown-Twiss (HBT) two-particle correlation functions opens new strategies for extracting the emission duration and testing the longitudinal expansion in heavy-ion collisions.
Heinz, U.   +3 more
core   +2 more sources

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

Analysis of the seismicity of Southeastern Sicily: a proposed tectonic interpretation

open access: yesAnnals of Geophysics, 2000
Southeastern Sicily is one of the Italian regions with high seismic risk and is characterised by the occurrence in the past of large destructive events (MS = 6.4-7.3) over a territory which is densely urbanised today.
M. S. Barbano, R. Azzaro
doaj   +1 more source

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