Results 41 to 50 of about 92,552 (263)

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Hydrocarbon generation characteristics and significance of accumulation of Upper Paleozoic source rocks in Dongpu Sag, Bohai Bay Basin

Shiyou shiyan dizhi, 2021
In order to clarify the conditions and rules of hydrocarbon accumulation of the Upper Paleozoic in the Dongpu Sag of Bohai Bay Basin, source rock evaluation, pyrolysis experiment and basin modelling were carried out in this paper, the history of ...
Xuejun WANG, Yongshui ZHOU, Honglei LI, Binfeng JIA, Yingying ZHANG   +4 more
doaj   +1 more source

Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs

FEBS Open Bio, EarlyView.
Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner, Hainan Zhu, Carol Christine Bosholm, Heuy‐Ching Wang, Tracy Criswell, Anthony Atala, Jian‐Xing Ma, Yuanyuan Zhang   +7 more
wiley   +1 more source

Palynostratigraphy, Palaeogeography and Source Rock Evaluation of the Nayband Formation at the Parvadeh area, Central Iran, Iran [PDF]

Journal of Sciences, Islamic Republic of Iran, 2015
The Nayband Formation was measured and sampled in Parvadeh area, southern Tabas city. In this area, this formation has a thickness of 1410 m, dividing into four members, namely Gelkan, Bidestan, Howz-e-sheikh and Howz-e-khan.
M. Ghavidel-Syooki, M. Yousefi, D. Mohnhoff   +2 more
doaj  

Artificial Intelligence and Mental Well‐Being in Adult Education: Implications for Practice and Professional Responsibility

New Directions for Adult and Continuing Education, EarlyView.
ABSTRACT Mental well‐being is central to adult learner success, yet many adult education institutions lack capacity to provide timely and accessible support. This article examines how artificial intelligence (AI) can strengthen mental health–adjacent supports in adult and continuing higher education, with attention to professional practice and ...
Adam L. McClain, Thomas Wade
wiley   +1 more source

Value of MRI Outcomes for Preventive and Early‐Stage Trials in Spinocerebellar Ataxias 1 and 3

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To examine the value of MRI outcomes as endpoints for preventive and early‐stage trials of two polyglutamine spinocerebellar ataxias (SCAs). Methods A cohort of 100 participants (23 SCA1, 63 SCA3, median Scale for the Assessment and Rating of Ataxia (SARA) score = 5, 42% preataxic, and 14 gene‐negative controls) was scanned at 3T up ...
Thiago J. R. Rezende, Emilien Petit, Young Woo Park, Sophie Tezenas du Montcel, James M. Joers, Jonathan M. DuBois, H. Moore Arnold, Michal Povazan, Ipek Özdemir, Guita Banan, Romain Valabregue, Philipp Ehses, Jennifer Faber, Chiadi U. Onyike, Peter B. Barker, Jeremy D. Schmahmann, Eva‐Maria Ratai, Sub H. Subramony, Thomas H. Mareci, Khalaf O. Bushara, Henry Paulson, Thomas Klockgether, Alexandra Durr, Tetsuo Ashizawa, Christophe Lenglet, Gülin Öz, READISCA Investigators   +26 more
wiley   +1 more source

Onasemnogene Abeparvovec in Patients With SMA: Interim Results of the RESTORE Registry in Japan

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective There are limited real‐world data regarding the safety and effectiveness of onasemnogene abeparvovec (OA; Zolgensma) infusion, a one‐time gene replacement therapy, for Japanese patients with spinal muscular atrophy (SMA). We aimed to improve understanding of the real‐world outcomes for OA in Japan.
Kayoko Saito, Kamal Benguerba, Ken Tsuchida, Kazushige Yazawa, Isao Tsumiyama, Hiromitsu Kayama, Sandra P. Reyna, Farid Khan, Richard S. Finkel   +8 more
wiley   +1 more source

Distinct Systemic Sclerosis Phenotypes Related to Ethnicity: An Opportunity to Personalize Care?

Arthritis Care &Research, EarlyView.
Objective The objective is to describe and compare demographic, clinical, and serological characteristics of patients with systemic sclerosis (SSc) according to ethnic background. Methods Participants enrolled in the Canadian Scleroderma Research Group cohort who self‐identified to a single ethnicity group were included.
Danick Goulet, Camille Guertin, Maggie Larché, Isabelle Ferdinand, Marie Hudson, May Y. Choi, Mohammed Osman, Janet Pope, Carter Thorne, Murray Baron, Sasha Bernatsky, Sabrina Hoa   +11 more
wiley   +1 more source

Genetic classification and geochemical evaluation of Upper Cretaceous carbonate reservoir oils in Dezful Embayment and Abadan Plain, SW Iran

Journal of Petroleum Exploration and Production Technology
The Upper Cretaceous carbonate reservoir oils from the Abadan Plain and Dezful Embayment in southwest Iran underwent analysis utilizing GC, GC-MS, and stable carbon isotope methods to elucidate the regional genetic oil family distribution.
Hossein Saadati, Ali Kadkhodaie, Mehrab Rashidi, Hossein Bahrami, Hashem Sarafdokht, Dmitriy A. Martyushev, Amir Abbass Jahangard   +6 more
doaj   +1 more source

Rock Rock Art as a Source of Knowledge For Ancient Maghreb

آثار الرافدين
:       The human sense of beauty is innate, and humans have expressed it in a way consistent with their natural instincts—a fact confirmed by anthropologists through their discovery of human art in archaeological sites.
Mohammed Mahfouz Al-Jumard Al-Jumard, Hussein Youssef Hazem Hazem   +1 more
doaj   +1 more source