Results 111 to 120 of about 319,846 (294)
Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis
FEBS Letters, EarlyView.Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee +7 more
wiley +1 more source
Sources of dissatisfaction with answers to the question of the meaning of life
, 2010 In this paper, I seek to diagnose the sources of our dissatisfaction with answers to the question of the meaning of life. I contend that some of these have to do with the question (its polyvalence and persistent vagueness) and some have to do with life ...
T. J. Mawson, Mawson, Timothy J.
core +1 more source
FEBS Letters, EarlyView.Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley +1 more source
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
The Structural Sources of Verb Meanings
Language Acquisition, 1990 Abstract This chapter presents the theory of syntactic bootstrapping. It shows fundamental problems with a theory of verb learning based solely on observations of the external world. It then shows how these problems can be overcome if those experiences are paired with information about the syntactic structure of the clause that the verb ...
openaire +1 more source
, 2013 We investigate the sources of betting constructions, and specifically their predicates. The notion of risking something of value on an outcome is a complex one. Culturally, some degree of disposability of property is required. The concept is nevertheless
Siewierska, Anna +2 more
core
, 2022 \(\bf Introduction: The experience of meaning seems to be crucial for psychic well-being. In the literature, there are reports of relationships between personality, illness, and life meanings.
Juckel, Georg (Prof. Dr. med.) +3 more
core
The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
Molecular Oncology, EarlyView.The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
wiley +1 more source
Nordidactica: Journal of Humanities and Social Science Education, 2014 The article uses a form of content focused conversation analysis to explore processes of learning and attributing meaning when upper secondary students work with two primary source assignments in history.
Patrik Johansson
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