Results 91 to 100 of about 166,223,834 (257)
RAM. Revista de Administração Mackenzie, 2018 Purpose: To describe the sources of the meaning of work. This research was carried out with civil servants who implement employment policies in the Federal District of Brazil, trying to reintegrate people back into the labor market.
Dulce M. J. Tannuri +1 more
doaj
An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes
FEBS Letters, EarlyView.GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg +14 more
wiley +1 more source
Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
FEBS Letters, EarlyView.Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Management interventions as conditions for motivation crowding of motivation in the European commission : a mediational analysis of basic needs satisfaction. Paper [PDF]
, 2009 Motivation of employees is crucial to achieve results within any organization, be it a public or a private organization (Rainey and Steinbauer 1999; Kojasteh 1993).
LSG Management of Meaning (MOM) +2 more
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Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source
Electronic Public Service Delivery: Exploring the Use of Focus Groups for Ex ante Program Evaluation [PDF]
, 2004 Eugène Loos +5 more
core +1 more source
Meaning and resilience in war-affected populations during crisis
Frontiers in PsychiatryIntroductionThe unprecedented events of October 7th, 2023, in Israel have profoundly impacted mental health and psychological functioning. This study aimed to explore how protective psychological factors—specifically meaning in life (MIL) and optimism ...
Pninit Russo-Netzer +3 more
doaj +1 more source
Epigenetic reprogramming of lineage switching in cancer
FEBS Letters, EarlyView.Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı +4 more
wiley +1 more source
343 HISTORY AND SOURCE STUDIES: ARE DIPLOMATIC DOCUMENTS HISTORICAL SOURCES?
Astra Salvensis, 2019 Historical science assumes that the basic research activity of a historian is work with historical sources. The role and meaning of historical sources in historical researches is gradually replaced the knowledge of the previous historiography.
Gulziya Akmadiyeva +4 more
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