Results 71 to 80 of about 319,846 (294)

Mutual influence between dictionaries and commentaries in understanding "Asāṭīr" [PDF]

open access: yesپژوهش نامه معارف قرآنی
The composition of "Asāṭīr al-Awwalīn" is found in nine verses of Qur'an. Disagreement between commentators under these verses is more and less rooted in understanding of "Asāṭīr" word.
Ahmad Amin Yousefi, ali hajikhani
doaj   +1 more source

A Dialectical Approach to Information Retrieval : Exploring a Contradiction in Terms

open access: yes, 2005
Information retrieval (IR) is the process of representing the meaning of documents so that people who want the information they contain can retrieve them. It is, therefore, centrally concerned with information and meaning.
Thornley, Clare Victoria   +2 more
core   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

open access: yesFEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy   +4 more
wiley   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

open access: yesFEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa   +5 more
wiley   +1 more source

Meaning making amongst South African survivors of violent crime

open access: yes, 2007
Includes bibliographical references (leaves 93-102)The aim of this study was to explore the meaning attributions, in terms of comprehensibility and significance, held by South African crime survivors in relation to the traumatic event, and to see if ...
Thacker, Mandy
core  

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

open access: yesFEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Meaningful Activities and Sources of Meaning for Community-Dwelling People Living with Dementia. [PDF]

open access: yesJ Am Med Dir Assoc, 2022
Allison TA   +8 more
europepmc   +1 more source

Diversity and complexity in neural organoids

open access: yesFEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

open access: yesFEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz   +11 more
wiley   +1 more source

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