Results 61 to 70 of about 319,846 (294)
The 'Value Chain of Meaning' and the new economy
, 2004 If there is a ‘value chain’ of meaning, corresponding tovalue chains in business, then a suggestive correlation can be explored between author/production, text/commodity and audience/consumer.
Hartley, John
core +1 more source
Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?
FEBS Letters, EarlyView.This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes +3 more
wiley +1 more source
FEBS Letters, EarlyView.The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li +2 more
wiley +1 more source
The 'search for meaning' in therapeutic recreation [PDF]
, 2022 Therapeutic Recreation (TR) has been likened to an existential therapy because it facilitates meaningful outcomes for participants. Logotherapy and Existential Analysis (LTEA) has previously been proposed as a suitable existential approach for TR ...
Hernesniemi, Miika S. J. +1 more
core
FEBS Letters, EarlyView.We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee +3 more
wiley +1 more source
The Appropriation of Symbolic Language in Worldview Education through Bibliodrama
Education Sciences, 2019 One of the main questions regarding Dutch primary education in our secularised and religiously diverse society—both with regards to public and religiously-affiliated schools—is how to get students acquainted with the symbolic language of ...
Bas van den Berg +1 more
doaj +1 more source
THE SOURCE OF THE LYMPHOCYTOSIS INDUCED BY MEANS OF HEAT [PDF]
Journal of Experimental Medicine, 1919 A striking number of mitotic figures have been observed in the germinal center of the spleen and lymph glands during the regeneration of the cellular elements of these organs after the destructive effect of heat. This enhanced cell proliferation is interpreted as more than compensating for the degenerated cells, because of the subsequent enlargement of
openaire +2 more sources
FEBS Letters, EarlyView.In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai +9 more
wiley +1 more source
Do Sources of Meaning Differentially Predict Search for Meaning, Presence of Meaning, and Wellbeing
, 2015 Meaning in life is vital for human wellbeing. Research has examined important sources of meaning: however, it has not yet investigated whether certain sources of meaning might be more predictive of overall meaning and wellbeing. A community sample of 247
Grouden, Melissa E., Jose, Paul E.
core
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source