Results 111 to 120 of about 280,542 (312)

R&D Sourcing, Joint Ventures and Innovation: A Multiple Indicators Approach [PDF]

open access: yes
This paper reexamines the limits of the firm in Research and Development (R&D). Using evidence drawn from industrial laboratories we study the causes and effects of R&D sourcing. We begin with the causes of sourcing, finding that Research Joint Ventures (
James D. Adams, Mircea Marcu
core  

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

open access: yesMolecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone   +11 more
wiley   +1 more source

Focused Proofreading: Efficiently Extracting Connectomes from Segmented EM Images [PDF]

open access: yes, 2014
Identifying complex neural circuitry from electron microscopic (EM) images may help unlock the mysteries of the brain. However, identifying this circuitry requires time-consuming, manual tracing (proofreading) due to the size and intricacy of these image
Plaza, Stephen M.
core  

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

open access: yesMolecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff   +11 more
wiley   +1 more source

Keeping the Gates on Twitter: Interactivity and Sourcing Habits of Lebanese Traditional Media

open access: yesInternational Journal of Communication, 2021
Using gatekeeping and sourcing frameworks, this study content analyzes Lebanese media tweets to examine the relationship between the use of sources and tweet popularity in a media environment marked by political parallelism and high diversity. The study
Claudia Kozman, Raluca Cozma
doaj  

Legislative Alert: FY2012 Financial Services [PDF]

open access: yes, 2011
[Excerpt] On behalf of the AFL-CIO, I am writing to urge you to support the inclusion of five important sourcing reforms in the FY 2012 Financial Sendees appropriations bill when conferees convene on this important ...
Samuel, William
core   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

open access: yesMolecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala   +15 more
wiley   +1 more source

MODERN APPLICATION OF INERT OPEN-CELL POROUS CERAMIC MATERIALS FOR DESIGNING NON-CONVENTIONAL SELF-ASPIRANTING BURNERS

open access: yesNonconventional Technologies Review
The paper refers to the application of inert porous ceramic materials with large open pores in the construction of porous burners, capable of contributing to increasing the combustion stability, increasing the combustion speed, and reducing nitrogen ...
Lucian Paunescu   +2 more
doaj  

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