Results 81 to 90 of about 280,542 (312)

Plasma extrachromosomal circular DNA as a biomarker in EGFR‐targeted therapy of non‐small cell lung cancer

open access: yesMolecular Oncology, EarlyView.
Detection of extrachromosomal circular DNA (eccDNA) in plasma samples from EGFR‐mutated non‐small cell lung cancer patients. Plasma was collected before and during treatment with the EGFR‐tyrosine kinase inhibitor osimertinib. Plasma eccDNA was detected in all cancer samples, and the presence of the EGFR gene on eccDNA serves as a potential biomarker ...
Simone Stensgaard   +5 more
wiley   +1 more source

Sourcing ethics in the textile sector: The case of C&A [PDF]

open access: yes
During the last years competition in the textile sector has increased, putting financial returns under considerable pressure. As a result, production has shifted to low wage countries in the third world.
Graafland, J.J.
core   +1 more source

The Direct Costs and Benefits of US Electric Utility Divestitures [PDF]

open access: yes, 2010
This paper studies the impact of divestiture on the efficiency and costs of electric utilities. The empirical literature shows that there exist economies of scope for electric utilities and that divestiture decreases distribution efficiency but increases

core   +3 more sources

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

open access: yesMolecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed   +10 more
wiley   +1 more source

New challenges in the study of lithic raw materials in central Italy at the dawn of metal working societies: La Pietra and other radiolarite quarry-workshops in Tuscany

open access: yesJournal of Lithic Studies, 2016
In central-southern Tuscany radiolarite has been used as a lithic raw material throughout prehistory. During the Copper Age it was selected for the local production of leaf-shaped artefacts. In the area considered, the Copper Age record is almost totally
Sem Scaramucci   +6 more
doaj   +1 more source

Competition and Technological Complexity in Procurement: An Empirical Study of Dual Sourcing [PDF]

open access: yes
The role of competition in defense procurement has long been controversial due to the extraordinary demand for technological advance, the relatively small production quantities involved and the importance of learning by doing.
Thomas P. Lyon
core  

Socio-Economic Sourcing: Benefits of Small Business Set-Asides in Public Procurement [PDF]

open access: yes, 2018
Purpose Small businesses are critical to economic health and encouraged in government spending by set-asides – annual small business sourcing goals that often are not attained.
Gravier, Michael J   +2 more
core   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

open access: yesMolecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra   +10 more
wiley   +1 more source

Greasing the wheels of international commerce: how services facilitate firms' international sourcing. [PDF]

open access: yes
We use unique plant-level data to study the link between the local availability of services and the decision of manufacturing firms to source materials from abroad.
Debaere, Peter   +2 more
core   +3 more sources

An assessment of supplier development in the Zimbabwean cotton industry

open access: yesCogent Business & Management
Supplier development in the form of contract farming has become the main sourcing strategy in agro-processing industry. However, it is not yet clear from the extant literature how investments in contract farming contribute towards yield per yield.
Paul Mukucha, Felix Chari
doaj   +1 more source

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