Results 241 to 250 of about 223,319 (307)

Why Differences in Methods and Resulting Misinterpretation of Telomere Data Might Affect Our Perspective on Aging and Its Reversibility by Clinical Interventions.

Neuroimmunomodulation
Karabatsiakis A.
europepmc   +1 more source

Personalized Follow Up and Genetic Diagnosis Update of <i>FMR1</i>-Related Conditions: A Change in Diagnosis, Prognosis and Expectations. [PDF]

Int J Mol Sci
Roche-Martínez A, Ramírez-Mallafré A, Joga-Elvira L, Manso-Bazus C, Rubio-Roy M, Baena-Diez N.   +5 more
europepmc   +1 more source

PROTAC‑Mediated HMGCR Depletion Reprograms Lipid Metabolism in Breast Cancer to Potentiate Photoimmunotherapy via Ferroptosis

Advanced Science, EarlyView.
This work introduces a study that identifies HMGCR as a novel target in TNBC and develops a light‐gated PROTAC nanomedicine. Upon irradiation, this agent selectively degrades HMGCR, reprogramming lipid metabolism to induce ferroptosis and potent antitumor immunity, thereby significantly enhancing photoimmunotherapy efficacy.
Tong Su, Guang Li, Yudong Guan, Qi Tian, Youzhi Qi, Yanqiu Zhang, Wenqian Wei, Xinxin Duan, Jiaxin Rui, Hongyan Zhu, Zengping Lin, Changchuan Xie, Zheni Xu, Yaying Wu, Xin Peng, Zhenjie Wang, Kun Chen, Xiaoyan Xin, Bing Zhang   +18 more
wiley   +1 more source

Emodin inhibits colon cancer tumor growth by suppressing tumor cell glycolysis through inhibition of NAT10-mediated PGK1 ac4C modification. [PDF]

Front Oncol
Wei Z, Lv Z, Zhang W.
europepmc   +1 more source

Fig A in S1 Text: Confirmation of gene involved in protein glycosylation deletion mutants by Southern blot analysis.

Heeji Moon (17474719), Eun Jung Thak (21673162), Yejin Choi (5123054), Sieun Kim (9132851), Jiyeun Park (12769605), Nahyun Lee (821123), Soobin Shin (17069150), Hosung Jeon (11914130), Jessica Winarto (18127974), Soyoung Choi (1849450), Ji Young Shin (9136598), Jung-Eun Kim (83763), Dae-Geun Song (532821), Hun Kim (211871), Gyung Ja Choi (162520), Hyun Ah Kang (17616744), Hokyoung Son (162502)   +16 more
openalex   +1 more source

ROS‐Responsive Wedelolactone Hydrogel Promotes Intervertebral Disc Repair by Disrupting the NF‐κB–LCN2 Inflammatory Feedback Loop

Advanced Science, EarlyView.
A mechanically robust, ROS‐responsive hydrogel is engineered to treat intervertebral disc degeneration by targeting the NF‐κB–LCN2 inflammatory feedback loop. By delivering wedelolactone specifically within oxidative niches, this system disrupts macrophage–disc cell crosstalk.
Zimei Wu, Yan Xu, Lang Qin, Zemin Ling, Yingjie Mai, Xiong Tian Guo, Jiajia Chen, Leping Yan, Lin Wang, Liming Bian, Fuxin Wei   +10 more
wiley   +1 more source

Antibody-induced internalization and degradation of PLA2R amplifies CD4⁺ T cell activation. [PDF]

Theranostics
Liu Y, Li Y, Zhou H, Yu J, Deng P, Xu W, Pan B, Zhang L, Zhou H, Zhang J, Liu X, Shi M, Dong X, Tong B, Bi E, Guo N, Hu Y.   +16 more
europepmc   +1 more source

Self‐Assembled Myricetin‐Arginine Conjugate Nanozymes for Targeted Suppression of Joint Inflammation and Osteoclastogenesis in Rheumatoid Arthritis

Advanced Science, EarlyView.
Carrier‐free myricetin‐arginine conjugate nanozymes (MANZs) have been fabricated through a Mannich reaction and spontaneous self‐assembly. MANZs selectively accumulate in inflamed joints by targeting M1 macrophages via CAT2‐mediated uptake. The nanozymes can effectively modulate macrophage polarization, suppress osteoclast differentiation, and mitigate
Jiachang Hong, Penghao Ji, Jinxi An, Junchao Huang, Ziheng Bu, Xudong Zhang, Wei Liu, Tingyu Wu, Sen Wang, Wei Zhu, Yuhui Li, Jixian Wan, Sudan Xu, Minfeng Huo, Peng Wu   +14 more
wiley   +1 more source

Inflammation-induced LncRNA SNHG1 orchestrates spermatogonium development in non-obstructive azoospermia via IL-17 A signaling pathway. [PDF]

Cell Mol Life Sci
Zhu Y, Li M, Zhan X, Liu L, Chen C, Zhou Y, He P, Hua R.   +7 more
europepmc   +1 more source

A southern blot assay for detection of hepatitis B virus covalently closed circular DNA from cell cultures. [PDF]

Methods Mol Biol, 2013
Cai D, Nie H, Yan R, Guo JT, Block TM, Guo H.   +5 more
europepmc   +1 more source