Results 261 to 270 of about 223,319 (307)

Dimorphic enantiostyly and its function for pollination by carpenter bees in a pollen‐rewarding Caribbean bloodwort

American Journal of Botany, EarlyView.
Abstract Premise Flowers that present their anthers and stigma in close proximity can achieve precise animal‐mediated pollen transfer, but risk self‐pollination. One evolutionary solution is reciprocal herkogamy. Reciprocity of anther and style positions among different plants (i.e., a genetic dimorphism) is common in distylous plants, but very rare in
Steven D. Johnson, Jeremy J. Midgley, Luis G. Bocourt‐Hernandez, F. G. Loiret, Patricia Ortega‐Rodés, Nicola Illing   +5 more
wiley   +1 more source

Covalent Protein Inhibitors via Tyrosine and Tryptophan Conjugation with Cyclic Imine Mannich Electrophiles

Angewandte Chemie, EarlyView.
Targeted covalent inhibitors (TCI) containing cyclic imine warheads react with tyrosine and tryptophan residues via the Mannich reaction. These cyclic imine warheads show comparable reaction kinetics to cysteine‐reactive electrophiles commonly used in TCIs.
Sijie Wang, Lei Wang, Marco Hadisurya, Siavash Shahbazi Nia, W. Andy Tao, Emily C. Dykhuizen, Casey J. Krusemark   +6 more
wiley   +2 more sources

Construction of pathogenic Sec16a mutation mouse model using CRISPR/Cas9

Animal Models and Experimental Medicine, EarlyView.
Yaqiang Hu et al. engineered a pathogenic Sec16a mutant mouse model using CRISPR/Cas9 technology. They observed that the Sec16a mutant mice displayed diminished learning and memory capabilities, along with a limb‐clasping phenotype upon tail suspension.
Yaqiang Hu, Zhiyang Zeng, Xinyu Ming, Shuming Yin, Yuting Guan, Liangcai Gao, Dali Li   +6 more
wiley   +1 more source

HBV p22-interacting protein C1QBP inhibits viral replication through impeding nucleocapsid formation and nuclear import. [PDF]

PLoS Pathog
Peng X, Liu CD, Mitra B, Kim ES, Sun N, Jurado A, Zhang H, Li S, Zhou T, Guo H.   +9 more
europepmc   +1 more source

Development of an in situ small intestinal injection technique for targeted macromolecule delivery and in vivo functional studies in mice

Animal Models and Experimental Medicine, EarlyView.
This study developed a minimally invasive, in situ small intestinal injection technique for mice, enabling targeted delivery of bioactive molecules while bypassing gastric degradation. Validation using functional assays and single‐cell RNA sequencing reveals high‐mobility group box 1–mediated epithelial responses, offering a translational tool for gut ...
Yawen Lai, Xintao Zhang, Tingting Luo, Wenhan Chen, Chenyu Ma, Haihua Luo, Jinghua Liu, Jia Xu   +7 more
wiley   +1 more source

Melk facilitates pulmonary artery smooth muscle cell proliferation and migration in pulmonary hypertension via modulation of YAP/TAZ signaling. [PDF]

Front Cell Dev Biol
Yang Q, Chen P, He X, Jian J, He M, Lin T, Zheng S, Liu D.   +7 more
europepmc   +1 more source

<i>In Vivo</i> engineering of transgenic mice for systemic human neutralizing antibody production against staphylococcal enterotoxin B. [PDF]

Front Immunol
Jiang Z, Jia B, Hu N, Zhang M, Xiao H, Chen G, Yu J, Li X, Shen B, Feng J, Wang J.   +10 more
europepmc   +1 more source

Fast and accurate quantification of double-strand breaks in microsatellites by digital PCR. [PDF]

Biol Methods Protoc
Palao C, Kovacs A, Teixeira MT, Richard GF.   +3 more
europepmc   +1 more source

Noninvasive Glucose Detection with Biodegradable Electrodes from Rice Starch Functionalized with a Carbon Quantum Dot/Nickel Oxide Nanocomposite

Analysis &Sensing, EarlyView.
The graphical abstract shows an eco‐friendly approach to fabricating a biodegradable electrochemical sensor. Carbon quantum dot/nickel oxide (CQD/NiO) nanocomposites are synthesized using Aloe arborescens leaf extract, which served as a natural reducing and stabilizing agent.
Nokwanda Ngema, Ryal Atson, Orlette Mkhari, Mahabubur Rahman Chowdhury   +3 more
wiley   +1 more source