Results 191 to 200 of about 57,771 (304)

Survivin and Aurora Kinase A control cell fate decisions during mitosis

Molecular Oncology, EarlyView.
Aurora A interacts with survivin during mitosis and regulates its centromeric role. Loss of Aurora A activity mislocalises survivin, the CPC and BubR1, leading to disruption of the spindle checkpoint and triggering premature mitotic exit, which we refer to as ‘mitotic slippage’.
Hana Abdelkabir, Shalitha Wickrama Arachchige, Sally P. Wheatley   +2 more
wiley   +1 more source

The determinants of sovereign risk premiums in the UK and the European government bond market: the impact of Brexit. [PDF]

Int Econ Econ Policy, 2022
Kadiric S.
europepmc   +1 more source

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

American Indian community engagement and the structural and social determinants of health: results from the THRIVE assessment. [PDF]

Front Public Health
Webb K, Posey S, Hirchak K, Beamon E, Milligan K, Wagon S, Fatupaito B, Kelley A.   +7 more
europepmc   +1 more source

Reduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity

Molecular Oncology, EarlyView.
A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He, Chiara Testini, Neda Hekmati, Altea Bonello, Aglaia Schiza, Emmanuel Nwadozi, Mia Phillipson, Carina Strell, Michael Welsh   +8 more
wiley   +1 more source

Private investments in climate change adaptation are increasing in Europe, although sectoral differences remain. [PDF]

Commun Earth Environ
Cortés Arbués I, Chatzivasileiadis T, Storm S, Ivanova O, Filatova T.   +4 more
europepmc   +1 more source

Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA

Molecular Oncology, EarlyView.
Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson, Anders Lade Nielsen, Boe Sandahl Sorensen   +2 more
wiley   +1 more source

Redefining Debt-to-Health, a triple-win health financing instrument in global health. [PDF]

Global Health
Hu Y, Wang Z, Zhou S, Yang J, Chen Y, Wang Y, Xu M.   +6 more
europepmc   +1 more source

Sovereign risk: An estimation model for the determinants of sovereign ratings

, 2016
The purpose of this study is to understand the determinants of sovereign risk which is assessed by sovereign ratings. Multiple regression model was used to estimate the coefficients of related macroeconomic and qualitative factors and linear transformation method is used to identify the dependent variable based on Fitch Ratings December 2015 sovereign ...
openaire   +2 more sources