Results 201 to 210 of about 66,099 (245)

Development of a preclinical testing platform for clinically relevant therapy for Dravet syndrome

Epilepsia, EarlyView.
Abstract Objective Patients with drug‐resistant epilepsy, including Dravet syndrome, are frequently prescribed multiple antiseizure medications. Nevertheless, people with Dravet syndrome often have inadequate seizure control, and there is an ongoing unmet clinical need to identify novel therapeutics.
Jeffrey A. Mensah, Kyle E. Thomson, Jennifer L. Huff, Tia Freeman, Christopher A. Reilly, Joseph E. Rower, Cameron S. Metcalf, Karen S. Wilcox   +7 more
wiley   +1 more source

<i>GJB2</i> enhances cancer stem cell properties by modulating <i>SOX2</i> expression via NF-κB pathway activation in lung adenocarcinoma. [PDF]

Transl Cancer Res
You Q, Huang T, He Z, Tao X, Zhang Y, Zhang H, Zhu S.   +6 more
europepmc   +1 more source

Epigenetic control of cell identities from epiblast to gastrulation

The FEBS Journal, EarlyView.
In this review, we present and contextualize current knowledge about the roles of epigenetic modifiers during the development of mouse epiblast to gastrulation stage. The epigenetic regulation of enhancer and promoter elements by DNA methylation, histone modifications, and chromatin accessibility in concert with lineage‐specific transcription factors ...
Katrin M. Schüle, Simone Probst
wiley   +1 more source

Silk fibroin hydrogel with recombinant silk fibroin/NT3 protein enhances wound healing by promoting type III collagen synthesis and hair follicle regeneration in skin injury. [PDF]

Mater Today Bio
Yan Y, Li M, Guo L, Zhang W, Wu R, Guan T, Ling J, Yang Y, Liu M, Gu X, Liu Y.   +10 more
europepmc   +1 more source

Generation of Immortal Cell Lines from the Adult Pituitary: Role of cAMP on Differentiation of SOX2-Expressing Progenitor Cells to Mature Gonadotropes

, 2011
Ginah L. Kim, Xiaomei Wang, Jennifer A. Chalmers, David R. Thompson, Sandeep Dhillon, Margaret M. Koletar, Denise D. Belsham   +6 more
openalex   +2 more sources

Neocortical neurogenesis: a proneural gene perspective

The FEBS Journal, EarlyView.
The neocortex is a mammalian‐specific brain region responsible for higher‐order cognitive functioning that shares fundamental similarities across species, but which is larger and more complex in humans. Proneural genes, encoding basic helix–loop–helix transcription factors (TFs), are evolutionarily conserved drivers of neurogenesis from fly to human ...
Lakshmy Vasan, Alexandra Moffat, Pierre Mattar, Carol Schuurmans   +3 more
wiley   +1 more source

DSG3 promotes bladder cancer growth and metastasis via AKT/GSK3β/β-catenin pathway. [PDF]

J Transl Med
Wang T, Du A, Peng Y, Yin J, Sun G, Yu Y, Sun Z, Chang Q, Gong K, Han S, Zhang L, Song D.   +11 more
europepmc   +1 more source

In vivo modeling of lethal congenital contracture syndrome 1 suggests pathomechanisms in cellular stress responses

The FEBS Journal, EarlyView.
Gle1 knockout mice fail to segregate cell lineages at the blastocyst stage, resulting in very early embryonic lethality. Gle1 knock‐in (KI) mice harboring a pathogenic variant giving rise to lethal congenital contracture syndrome 1 show both known and novel innervation defects, supportive of multiorgan pathology in human fetuses.
Tomáš Zárybnický, Sonja Lindfors, Saana Metso, Julia Koivula, Zoltan Szabo, Rasmus Valtonen, Mikko Tulppo, Johanna Magga, Samu Saarimäki, Sonja Bläuer, Ilkka Miinalainen, Risto Kerkelä, Petteri. T. Piepponen, Vootele Voikar, Juho Väänänen, Riikka Kivelä, Bhagwan Yadav, Hanna Lindgren, Pirkko Mattila, Fu‐Ping Zhang, Petra Sipilä, Reetta Hinttala, Satu Kuure   +22 more
wiley   +1 more source

Phaeochromocytomas and paragangliomas harbour tumour-initiating SOX2+ stem cells

Kemkem Y, Quinn M, Kövér B, Santambrogio A, Kaufman-Cook J, Sherwin O, Scriba LD, Brempou D, Segoviano MV, Cameron D, Berger I, Ng W, Nonaka D, Theodoropoulou M, Pamporaki C, Carroll PV, Izatt L, Chapple JP, Bornstein SR, Bechmann N, Steenblock C, Oakey RJ, Andoniadou CL.   +22 more
europepmc   +1 more source

Pluripotency genes of mammals: a network at work. [PDF]

Front Bioeng Biotechnol
Cancedda R, Mastrogiacomo M.
europepmc   +1 more source