Results 231 to 240 of about 70,586 (295)

The Role of Hedgehog Signaling in Non-small Cell Lung Cancer: Targeting Tumor Invasion, Therapy Resistance and Novel Therapeutic Strategies. [PDF]

Int J Biol Sci
Kang Y, Zheng H, Wen Q, Fan S.
europepmc   +1 more source

Astrocytic TCF7L2 Impacts Brain Osmoregulation and Restricts Neuronal Excitability

Glia, Volume 74, Issue 2, February 2026.
Astrocytic TCF7L2 impacts extracellular glutamate and glutamine levels. Loss of astrocytic TCF7L2 disrupts extracellular potassium clearance. TCF7L2‐dependent astrocytic changes reduce neuronal excitability. ABSTRACT Astrocytes differentiate and mature during postnatal development, but the molecular mechanisms linking their maturation to neuronal ...
Mariusz Popek, Krzysztof Goryca, Dorota Adamska, Joanna Urban‐Ciećko, Katarzyna Hryniewiecka, Marcin Lipiec, Tomasz Grzegorz Krawczyk, Kamil Rafalko, Alicja Ławicka, Shane A. Liddelow, Lukasz Mateusz Szewczyk   +10 more
wiley   +1 more source

CRISPR screen reveals SOX2 as a critical regulator of CD133 and cellular stress response in glioblastoma. [PDF]

Sci Rep
Savage N, Danis E, Chokshi CR, Custers S, Shaikh MV, Miletic P, Venugopal C, Brown KR, Vibhakar R, Moffat J, Singh SK.   +10 more
europepmc   +1 more source

Inhibition of FOS‐Like Antigen 1 Reduces Chemoresistance to Temozolomide Through Stemness Reprogramming via IL‐6/STAT3Tyr705 Pathway

MedComm, Volume 7, Issue 2, February 2026.
The role of FOSL1 in TMZ response to GBM. FOSL1 enhances TMZ resistance by promoting cell cycle progression, MGMT expression, and IL‐6‐pSTAT3Tyr705‐stemness axis. VEM is a potential candidate drug for alleviating TMZ resistance in GBM, highlighting a new approach for chemo‐resistant GBM treatment.
JeongMin Sim, JeongMan Park, JinHyung Heo, Yu Jin Kim, Dongkil Kim, Yong Hyun Jeon, Jae‐Eon Lee, Seon Hee Choi, Hak Jin Kim, So Jung Hwang, Junhyung Kim, Kyung Gi Cho, Jihwan Yoo, Ju Hyung Moon, Jong‐Seok Moon, Kyoung Su Sung, Jaejoon Lim   +16 more
wiley   +1 more source

A tissue boundary orchestrates the segregation of inner ear sensory organs. [PDF]

Elife
Chen Z, Żak M, Xu S, de Andrés J, Daudet N.   +4 more
europepmc   +1 more source

Molecular alterations in high‐grade neuroendocrine tumors of the small intestine

The Journal of Pathology, Volume 268, Issue 2, Page 215-226, February 2026.
Abstract High‐grade neuroendocrine tumors of the small intestine are separated into two groups: well‐differentiated neuroendocrine tumors (NETs, high‐grade) and poorly differentiated neuroendocrine carcinomas (NECs). They represent very rare entities, with few molecular data available, and are very challenging to treat.
Agathe Hercent, Julien Masliah‐Planchon, David Cohen, Remy Nicolle, Jean‐Yves Scoazec, Philippe Ruszniewski, Ivan Bièche, Louis de Mestier, Anne Couvelard, Jerome Cros   +9 more
wiley   +1 more source

Innervation Drives Postembryonic Expansion of the Zebrafish Anterior Lateral Line System. [PDF]

J Comp Neurol
Christiansen TJ, Venkataraman V, Prince VE.   +2 more
europepmc   +1 more source

Transcriptional repression of SOX2 by p53 in cancer cells regulates cell identity and migration [PDF]

Patricia Lado‐Fernández, Jéssica M. Vilas, Tânia Fernandes, Carmen Carneiro, Sabela Da Silva‐Álvarez, Valentín Estévez‐Souto, Pablo Pedrosa, Miguel González‐Barcia, Luis E. Abatti, Jennifer A. Mitchell, Carmen Rivas, Gema Moreno‐Bueno, Anxo Vidal, Manuel Collado   +13 more
openalex   +1 more source

In Vivo Chemical Reprogramming Is Associated With a Toxic Accumulation of Lipid Droplets Hindering Rejuvenation

Aging Cell, Volume 25, Issue 2, February 2026.
Partial chemical reprogramming significantly increases mitochondrial interaction networks, affects mitochondrial morphology, speeds up mitochondrial movement dynamics, increases mitochondrial transmembrane potential, and induces TCA cycle stress. These changes in mitochondrial function contribute to lipid droplet accumulation, acute kidney injury, and ...
Wayne Mitchell, Cecília G. de Magalhães, Alexander Tyshkovskiy, Yushi Uchida, Ludger J. E. Goeminne, Takaharu Ichimura, Emery L. Ng, Alibek Moldakozhayev, Joseph V. Bonventre, Vadim N. Gladyshev   +9 more
wiley   +1 more source

Depleting CBR1 increases chemosensitivity by reducing stemness and quiescence traits in non-small cell lung cancer. [PDF]

J Zhejiang Univ Sci B
Li W, Zhao J, Lan W, Ye X, Ying K.
europepmc   +1 more source