Results 241 to 250 of about 70,586 (295)

Author response: NFATc2 enhances tumor-initiating phenotypes through the NFATc2/SOX2/ALDH axis in lung adenocarcinoma

, 2017
Zhijie Xiao, Jing Liu, Siqi Wang, Yun Zhu, Xuyuan Gao, Vicky Pui‐Chi Tin, Jing Qin, Junwen Wang, Maria Pik Wong   +8 more
openalex   +1 more source

Enhancer‐dependent gene regulation in space, time, and malignancies

International Journal of Cancer, Volume 158, Issue 2, Page 357-367, 15 January 2026.
Abstract Control of cell‐type‐specific gene activation requires the coordinated activity of distal regulatory elements, including enhancers, whose inputs must be temporally integrated. Dysregulation of this regulatory capacity, such as aberrant usage of enhancers, can result in malignant transformation of cells.
Belinda Blum, Victoria Dachtler, Angelika Feldmann   +2 more
wiley   +1 more source

Tumor-initiating stem cells fine-tune the plasticity of neutrophils to sculpt a protective niche. [PDF]

Cancer Cell
Guo W, Luan J, Huang X, Leon D, Gang S, Nicholson B, Bertacchi B, Bolotin D, Lingen MW, Pearson AT, Izumchenko E, Rosenberg AJ, Agrawal N, Vokes EE, Punyawatthananukool S, Narumiya S, Gunzer M, Ballesteros I, Hidalgo A, Miao Y.   +19 more
europepmc   +1 more source

Establishment and optimization of the two‐step induction system for generating primordial germ cell‐like cells from chicken embryonic stem cells

FEBS Open Bio, Volume 16, Issue 1, Page 161-177, January 2026.
This study optimizes a two‐step induction system to generate PGCLCs from chicken ESCs. The induced cells express germline markers and migrate to gonads in ovo, offering a novel approach for avian genetic resource conservation. Primordial germ cells (PGCs) are the progenitor cells of sperm and eggs.
Zeyu Li, XianShuai Xu, GuangZheng Liu, XiaoQian Lv, JiuZhou Song, HongYan Sun, YingJie Niu, QiSheng Zuo, Wei Han, BiChun Li, Kai Jin   +10 more
wiley   +1 more source

Iterative improvement of deep learning models using synthetic regulatory genomics. [PDF]

Genome Res
Ribeiro-Dos-Santos AM, Maurano MT.
europepmc   +1 more source

Multi‐Omics Integration for Advancing Glioma Precision Medicine

Annals of Clinical and Translational Neurology, Volume 13, Issue 1, Page 4-13, January 2026.
ABSTRACT Gliomas are among the most malignant and aggressive tumors of the central nervous system, characterized by the absence of early diagnostic markers, poor prognosis, and a lack of effective treatments. Advances in high‐throughput technologies have facilitated a refined molecular classification of gliomas, incorporating genetic features. However,
Maria Guarnaccia, Valentina La Cognata, Giulia Gentile, Giovanna Morello, Sebastiano Cavallaro   +4 more
wiley   +1 more source

Decoding the role of DNA sequence on protein-DNA co-condensation. [PDF]

PLoS Comput Biol
Singh RK, Swain P, Ganji M, Choubey S.
europepmc   +1 more source

Differentiation Treatment Applied to Lung Cancer Model Reduces Pathogenic Traits in Vitro

Advanced Biology, Volume 10, Issue 1, January 2026.
Non‐small cell lung cancer cells (A549) treated with a differentiation medium showed strong reduction in proliferation, migration, clonogenicity, spheroid formation and stemness markers, with enhanced adhesion properties and alveolar features, all pointing to a notably less aggressive phenotype in support of differentiation therapy as a promising ...
Alice Grossi, Paola Fulghieri, Abdurakhmon Aduvaliev, Karen Soffiantini, Irene Oldrati, Margherita Cavallo, Marco Biggiogera, Giorgia Pellavio, Umberto Laforenza, Monica Savio, Virginie Sottile   +10 more
wiley   +1 more source

Author Correction: SOX2 drives esophageal squamous carcinoma by reprogramming lipid metabolism and histone acetylation landscape. [PDF]

Nat Commun
Wang Z, Dai R, Kang L, Yang H, Chen Z, He J, Shu L, Zhong Y, Zhang Y, Hua Z, Huang Y, Jiang Y, Li J, Xu L, Lan F, Lin SH, Wong J.   +16 more
europepmc   +1 more source

Tunable Synthetic Hydrogel Modulates Hepatic Lineage Specification of Human Liver Organoid

Advanced Functional Materials, Volume 36, Issue 7, 22 January 2026.
In this study, a synthetic hydrogel is reported that supports the formation of hiPSC‐derived human liver organoids (HLOs). Hepatic lineage specification can be modulated via conjugation of RGD peptide to hydrogel: RGD‐conjugated hydrogels promote cholangiocyte differentiation, whereas RGD‐free hydrogels favor hepatocyte commitment of HLO cells.
Lei Wang, Lasse Riediger, Qi Rao, Xun Xu, Yan Nie, Yiduo Zhou, Junyao Zhang, Peng Tang, Weiwei Wang, Frank Tacke, Adrien Guillot, Ludovic Vallier, Irene Talon, Wenzhong Li, Yi‐An Yang, Rainer Haag, Nan Ma   +16 more
wiley   +1 more source