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Sox2 Requirement in Sonic Hedgehog-Associated Medulloblastoma
Cancer Research, 2013Abstract The transcription factor Sox2 has been shown to play essential roles during embryonic development as well as in cancer. To more precisely understand tumor biology and to identify potential therapeutical targets, we thoroughly investigated the expression and function of Sox2 in medulloblastoma, a malignant embryonic brain ...
Ahlfeld, J +5 more
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Sox2 as a servant of two masters
Nature Immunology, 2015The transcription factor Sox2 has an additional function in neutrophils, as a cytoplasmic sensor of DNA. Upon binding bacterial DNA, Sox2 initiates a signaling cascade dependent on the kinase TAK1 and adaptor TAB2 that culminates in the expression of genes encoding pro-inflammatory molecules.
Arun K, Mankan, Veit, Hornung
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Expression of Sox2 in human cervical carcinogenesis
Human Pathology, 2010Sox2 is a key transcription factor for embryonic development and plays a critical role in determining the fate of stem cells. Recently, Sox2 has been detected in several human tumors, indicating a potential function in tumorigenesis. We initially reported remarkably increased nuclear Sox2 staining in cervical carcinomas compared with normal cervix (P <
Jing, Ji, Peng-Sheng, Zheng
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SOX2 anophthalmia syndrome and dental anomalies
American Journal of Medical Genetics Part A, 2015SOX2 anophthalmia syndrome is an uncommon autosomal dominant syndrome caused by mutations in the SOX2 gene and clinically characterized by severe eye malformations (anophthalmia/microphthalmia) and extraocular anomalies mainly involving brain, esophagus, and genitalia.
Oscar Francisco, Chacon-Camacho +3 more
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EPHA2 Regulates SOX2 during Esophageal Development
AbstractThe human esophagus, derived from the anterior foregut endoderm, requires proper dorsal-ventral patterning for development. The transcription factor SOX2, crucial in this process, when dysregulated, leads to congenital esophageal abnormalities.Tianxia Li +7 more
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SOX2 functions in adult neural stem cells
Trends in Neurosciences, 2005Sox2 is expressed highly in the neuroepithelium of the developing CNS and has been shown to function in neural stem cells. Because Sox2-null mutant mice fail to develop beyond implantation, the role of SOX2 in the CNS has lacked validation. A new genetic model addresses the role of SOX2 in the adult brain and provides evidence that it is involved in ...
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Sox2 and DNA flexibility dictate nucleosome engagement and Sox2-Oct4 synergism
Biophysical JournalEvgenia N. Nikolova +1 more
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