Results 151 to 160 of about 5,187,142 (285)

Chemotherapy‐Activated GSK3β‐DNMT1 Signaling Upregulates CD47 to Evade Macrophage Phagocytosis and Drive Temozolomide Resistance in Glioblastoma

Advanced Science, EarlyView.
Temozolomide treatment activates GSK3β, driving DNMT1 phosphorylation, destabilization, and CD47 promoter hypomethylation in glioblastoma. This epigenetic shift upregulates CD47, enabling TMZ‐treated GBM cells to evade macrophage phagocytosis, survive chemotherapy, and acquire resistance.
Jie Li, Shuai Ying, Yi Zhang, Jingjing Wang, Quan Wan, Lingli Gong, Daxing Xu, Zhenkun Yang, Hongnian Lu, Ying Yin, Xiangming Fang, Zhening Pu   +11 more
wiley   +1 more source

Twin‐Lever Multifunctional Meta‐Optics With High Longitudinal Tolerance

Advanced Science, EarlyView.
We introduce a single‐layer, CMOS‐compatible metasurface that allows for polarization‐programmable, achromatic broadband dual‐mode imaging with high longitudinal tolerance. The twin‐lever design combines bright‐field focusing and vortex‐based edge‐enhanced imaging while managing axial intensity distribution from 488 to 633 nm.
Isma Javed, Kyungtae Kim, Aqib Raza Shah, Dohyun Kang, Joohoon Kim, Azhar Javed Satti, Xuefeng Liu, Muhammad Zubair, Jichuan Xiong, Muhammad Qasim Mehmood, Junsuk Rho   +10 more
wiley   +1 more source

14‐3‐3γ Protects Against Postoperative Cognitive Dysfunction by Regulating Tau Thr205 Phosphorylation and Synaptic Integrity

Advanced Science, EarlyView.
Integrative multi‐cohort analyses identify 14‐3‐3γ as a biomarker and regulator of cognitive vulnerability. Experimental studies show that 14‐3‐3γ loss is associated with Tau Thr205 phosphorylation, synaptic dysfunction, and cognitive impairment, while genetic overexpression or pharmacological stabilization of 14‐3‐3γ confers protective effects in ...
Shouqiang Zhu, Xue Han, Heng Zhang, Chang Ye, Tianjiao Xia, Xiaoping Gu   +5 more
wiley   +1 more source

Concurrent data and power transmission using mode division multiplexing over a two-mode fiber

Next-generation mode division multiplexing (MDM) systems aim to integrate concurrent functionalities within a single optical fiber efficiently. In this work, we report on harnessing MDM to simultaneously provide data transmission and power delivery over ...
Ashry, Islam, Ng, Tien Khee, Kang, Chun Hong, Ooi, Boon S., Rjeb, Alaaeddine, Marin, Juan M.   +5 more
core   +1 more source

A Dual‐Mode In Situ EV‐miRNA Profiling Platform for Machine‐Learning‐Assisted Gastric Cancer Liquid Biopsy

Advanced Science, EarlyView.
An in situ dual‐mode platform integrates fusogenic liposomes with localized autocatalytic DNA circuits for plasma‐derived extracellular vesicle microRNA analysis. Following membrane fusion, target miRNAs trigger feedback‐assisted LECHA amplification inside intact vesicles, generating fluorescence and electrochemical outputs. Machine learning integrates
Wenbin Li, Rui Fan, Kun Xie, Jiehua Zhong, Yitong Zhu, Tingting Ji, Yuanyuan Qin, Shijin Peng, Yu Zhang, Yuhang Guo, Tiange Zhang, Chunchen Liu, Bo Li, Lei Zheng, Ye Zhang, Xiaohui Yan   +15 more
wiley   +1 more source

Spatiotemporal Thermal Modulation and Patterning using a Programmable 1024 Element Microheater Array

Advanced Science, EarlyView.
Programmable microheater arrays are essential for a variety of applications. However, large arrays have thus far not been realized. We introduce a programmable 32×$\times$32 microheater array consisting of heating elements – each smaller than 300 μm$\umu{\rm m}$.
Rahul Goyal, Jang‐Hwan Han, Sadaf Pashapour, Peer Fischer   +3 more
wiley   +1 more source

Equalization Techniques based on Cyclic Prefix in Space Division Multiplexing Systems

Guangtongxin yanjiu
【Objective】In Space Division Multiplexing (SDM) system, in order to achieve mode demultiplexing, it is necessary to adopt Multiple Input Multiple Output (MIMO) equalization scheme at the receiving end.
WANG Liuzhu, ZHENG Zhilong, XUE Yuling, HU Shaohua, ZHANG Jing, QIU Kun   +5 more
doaj  

A CD14‐Targeting In Situ Hydrogel Directs Macrophage Reprogramming to Minimize Scar Formation

Advanced Science, EarlyView.
A CD14‐targeting in situ hydrogel formed from a microbial polysaccharide rapidly remodels the immune microenvironment by reprogramming macrophage polarization, suppressing excessive inflammation, and coordinating tissue regeneration. This multifunctional hydrogel promotes scar‐reduced wound repair through enhanced angiogenesis, collagen remodeling, and
Rui Fang, Simeng Chen, Qiaozhen Liu, Wenwen Ni, Xi Xu, Jianfa Zhang   +5 more
wiley   +1 more source

Chronic Stress Promotes Gastric Cancer Metastasis by Inducing Microbiota‐Associated Kynurenine Accumulation and Macrophage Remodeling

Advanced Science, EarlyView.
Chronic stress reshapes the gut microbiota and enriches Lactobacillus reuteri, promoting microbiota‐associated kynurenine accumulation through altered tryptophan metabolism. Kynurenine drives immunosuppressive remodeling of tumor‐associated macrophages through TNFR2–C/EBPβ signaling, thereby enhancing gastric cancer dissemination.
Sicheng Zhao, Zhiyuan Song, Jingcheng Zhang, Jiaheng Lou, Shuo Zhang, Boqiang Liu, Yunhai Wei, Fengmei Qiu, Tao Jiang, Guangji Zhang   +9 more
wiley   +1 more source

High-throughput non-orthogonal interleaved random space-time coding for multi-source cooperation

, 2008
In this paper, we propose a novel distributed Interleaved Random Space-Time Code (IR-STC) designed for Multi-Source Cooperation (MSC) employing various relaying techniques, namely Amplify-Forward, Decode-Forward, Soft-Decode-Forward and Differential ...
Zhang, Rong, Hanzo, Lajos
core